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Pathology & Immunology

Houston, Texas

Pathology and Immunology
Pathology & Immunology
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Faculty

Thomas M. Wheeler, M.D.Professor and Chair

Education

  • M.D., Baylor College of Medicine, 1977 (High Honors)

Residency

  • Resident, Baylor College of Medicine, Anatomic and Clinical Pathology, 1977-1981
  • Chief Resident, Baylor College of Medicine, 1980-1981

Specialty

  • Anatomic and Clinical Pathology
  • Cytopathology
  • Genitourinary Pathology
  • Pathology of Asbestos Associated Diseases

Board Certification

  • American Board of Pathology, Anatomic and Clinical, 1981, recertified 1999
  • American Board of Pathology, Cytopathology, 1990

Current Position

  • Chairman, Department of Pathology, Baylor College of Medicine, Houston, Texas, 2004-present

Professional Positions Held

  • Harlan J. Spjut, M.D. Professor of Pathology, 2001-present
  • Associate Chairman, Department of Pathology, Baylor College of Medicine, Houston, Texas, 1995-present
  • Professor of Pathology & Urology, Baylor College of Medicine, Houston, Texas, 1995-present

Honors and Awards

  • College:
  • Alpha Chi Honor Society
  • American Institute of Chemists Award (outstanding senior student in Chemistry)
  • Outstanding alumnus, Houston Baptist University, 1997
  • Medical School:
  • Alpha Omega Alpha, 1976--present
  • Stuart A. Wallace Award (outstanding student in Pathology), 1976
  • Award for excellence in Physiology, 1975
  • Faculty:
  • Voted by peers to be included in listing of The Best Doctors in America, 1998-present
  • Herbert Lansky Award, College of American Pathologists, 1999
  • Life Member of the National Registry of Who's Who, 2001
  • Voted by peers to be included in listing of America's Top Doctors, 2001-present
  • George T. Caldwell, MD Distinguished Service Award, Texas Society of Pathologists, 2007

Membership on professional organizations

  • Alpha Omega Alpha
  • American Board of Pathology, Anatomic
  • Pathology Test Committee, 1995-99
  • American Association for Cancer Research
  • American Foundation for Thyroid Patients, Medical Advisory Board, 1998-1999
  • American Medical Association
  • American Society for Clinical Pathology
  • American Society of Cytopathology
  • American Society of Investigative Pathology
  • American Thyroid Association
  • American Urological Association
  • Association of Pathology Chairs
  • College of American Pathologists:
  • State Advisory Committee, 1994-97
  • Chairman, 1999-2000
  • Delegate to House of Delegates, 1993-2003
  • Government Affairs Committee, 1996-2003
  • Council on Government and Professional Affairs, 1999-2003
  • Nominating Committee 2000
  • Chair, 2001, 2005-2006
  • Education Committee 2004-present
  • Council on Scientific Affairs, 2004-present, chair 2005-2009
  • Board of Governors, 2003-2006
  • Executive Committee, 2005-present
  • Chair, Ad Hoc Work Group for Pathology Report Standardization, 2006-2008
  • Harris County Medical Society
  • Houston Society of Clinical Pathologists:
  • President, 1992
  • Scientific Seminar Chair 1988, 2001
  • International Society of Urological Pathology
  • Texas Society of Cytology, President, 1988
  • Texas Society of Pathologists: Alternate
  • Delegate, 1993-1995
  • Delegate 1995-present
  • Secretary 1997
  • President-Elect 1998
  • President 1999
  • Chair Nominating Committee 2000
  • The Thyroid Society for Education and Research, Board of Directors, 1993-98
  • U.S. and Canadian Academy of Pathology, Abstract Review Board, 1997-2000, 2006-2009
  • Editorial Board:
  • Human Pathology, 1996-present
  • Prostate, 1999-present
  • Clinical Thyroidology
  • American Journal of Surgical Pathology, 2000-present
  • American Journal of Translational Research, 2008-present
  • Executive Advisory Board:
  • Archives of Pathology & Laboratory Medicine, 2005-present
  • Ad hoc Reviewer:
  • Cancer
  • Journal of Urology
  • Modern Pathology
  • British Journal of Urology
  • Urology
  • Cancer Research
  • Journal of Clinical Oncology
  • Clinical Cancer Research
  • American Journal of Pathology
  • New England Journal of Medicine

Representative Publications

  • Weiss G, Cottrell S, Distler J, Schatz P, Kirstiansen G, Ittmann MI, Haefliger C, Lesche R, Hartmann A, Corman J, Wheeler TM . DNA methylation of the PITX2 gene promoter region is a strong independent prognostic marker for biochemical recurrence in prostate cancer patients after radical prostatectomy. J Urol 2008 . In press.
  • Evans AJ, Henry PC, Van der Kwast TH, Tkachuk DC, Watson K, Lockwood GA, Fleshner NE, Cheung C, Belanger EC, Amin MB, Boccon-Gibod L, Bostwick DG, Egevad L, Epstein JI, Grignon DJ, Jones EC, Montironi R, Moussa M, Sweet JM, Trpkov K, Wheeler TM , Srigley JR. Interobserver variability between expert urologic pathologists for extraprostatic extension and surgical margin status in radical prostatectomy specimens. Am J Surg Pathol . 2008 Oct; 32 ( 10 ): 1503-12 .
  • Latour M, Amin MB, Billis A, Egevad L, Grignon DJ, Humphrey PA, Reuter VE, Sakr WA, Srigley JR, Wheeler TM , Yang XJ, Epstein JI. Grading of invasive cribriform carcinoma on prostate needle biopsy: an interobserver study among experts in genitourinary pathology. Am J Surg Pathol . 2008 Oct; 32 ( 10 ): 1532-9 .
  • Goldsmith JD, Siegal GP, Suster S, Wheeler TM , Brown RW. Reporting guidelines for clinical laboratory reports in surgical pathology. Arch Pathol Lab Med . 2008 Oct; 132 ( 10 ): 1608-16 .
  • Iczkowski KA, Hossain D, Torkko KC, Qian J,
  • Lucia MS, Wheeler TM , Rewcastle JC, Bostwick DG. Preoperative Prediction of Unifocal, Unilateral, Margin-Negative, and Small Volume Prostate Cancer. Urology . 2008 Jun; 71 ( 6 ): 1166-71.
  • Hammerich KH, Hille S, Ayala GE, Wheeler TM , Engers R, Ackermann R, Mueller-Mattheis V. Malignant advanced granulosa cell tumor of the adult testis: case report and review of the literature. Hum Pathol . 2008 May; 39 ( 5 ): 701-9 .
  • Swindle P, Eastham JA, Ohori M, Kattan MW, Wheeler T , Maru N, Slawin K, Scardino PT. Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens. J Urol . 2008 May; 179 ( 5 Suppl ): S47-51.
  • Eggener SE, Scardino PT, Carroll PR, Zelefsky MJ, Sartor O, Hricak H, Wheeler TM , Fine SW, Trachtenberg J, Rubin MA, Ohori M, Kuroiwa K, Rossignol M, Abenhaim L; International Task Force on Prostate Cancer and the Focal Lesion Paradigm. Focal Therapy for Localized Prostate Cancer: A Critical Appraisal of Rationale and Modalities. J Urol . 2007 Dec; 178 ( 6 ): 2260-7
  • Kiniwa Y, Miyahara Y, Wang HY, Peng W, Peng G, Wheeler TM , Thompson TC, Old LJ, Wang RF. CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer. Clin Cancer Res . 2007 Dec 1; 13 ( 23 ): 6947-58 .
  • Eastham JA, Kuroiwa K, Ohori M, Serio AM, Gorbonos A, Maru N, Vickers AJ, Slawin KM, Wheeler TM , Reuter VE, Scardino PT. Prognostic significance of location of positive margins in radical prostatectomy specimens. Urology . 2007 Nov; 70 ( 5 ): 965-9 .
  • Yanagisawa N, Li R, Rowley D, Hao L, Kadmon D, Miles BJ, Wheeler TM , Ayala GE. Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy. Hum Pathol . 2007 Nov;38(11):1611-20.
  • Yang G, Addai J, Wheeler TM , Frolov A, Miles BJ, Kadmon D, Thompson TC. Correlative evidence that prostate cancer cell-derived caveolin-1 mediates angiogenesis. Hum Pathol . 2007 Nov;38(11):1688-95.
  • Li R, Erdamar S, Dai H, Wheeler TM , Frolov A, Scardino PT, Thompson TC, Ayala GE. Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer. Hum Pathol. 2007 Oct;38(10):1501-7.
  • Ishii J, Ohori M, Scardino P, Tsuboi T, Slawin K, Wheeler T . Significance of the craniocaudal distribution of cancer in radical prostatectomy specimens. Int J Urol . 2007 Sep;14(9):817-21.
  • Cordon-Cardo C, Kotsianti A, Verbel DA, Teverovskiy M, Capodieci P, Hamann S, Jeffers Y, Clayton M, Elkhettabi F, Khan FM, Sapir M, Bayer-Zubek V, Vengrenyuk Y, Fogarsi S, Saidi O, Reuter VE, Scher HI, Kattan MW, Bianco FJ, Wheeler TM , Ayala GE, Scardino PT, Donovan MJ. Improved prediction of prostate cancer recurrence through systems pathology. J Clin Invest . 2007 Jul;117(7):1876-83.

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