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Pathology & Immunology

Houston, Texas

Pathology and Immunology
Pathology & Immunology
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Faculty

Perumal Thiagarajan, M.D.Professor

Education

  • M.B.B.S. (Equivalent to M.D. in U.S.), Tirunelveli Medical College, India, July 1967 - Jan 1974

Internship

  • Internal Medicine,Long Island College Hospital, July 1974 - June 1975

Residency

  • Internal Medicine, Veterans Administration and Mount Sinai Hospital, July 1975 - June 1976

Fellowship

  • Clinical Fellow in Hematology/Oncology Veterans Administration and Mount Sinai Hospital, July 1976 - June 1978
  • Research Fellow in Hemostasis, Cardeza Foundation for Hematological Research, Jefferson Medical College of Philadelphia, July 1978 - June 1980

Specialty

  • Hematology

Board Certification

  • Internal Medicine
  • Hematology
  • Pathology (hematology)

Area of Interest

  • Hemostasis
  • Thrombosis

Current Position

  • Professor of Medicine and Pathology, Baylor College of Medicine
  • Director, Transfusion Medicine and Hematology Laboratory Michael E. DeBakey VA Medical Center

Professional Positions Held

  • Professor of Medicine and Pathology, Baylor College of Medicine, Sep. 2001 - To present
  • Professor of Medicine, University of Texas Medical School, July 2000 - Sept. 2001
  • Associate Professor of Medicine, University of Texas Medical School, Nov. 1993 - 2001
  • Associate Professor of Medicine, University of Washington, July 1989 - Nov. 1993
  • Assistant Professor of Medicine, University of Washington, Seattle, May 1986 - June 1989
  • Assistant Professor of Medicine, Member, Cardeza Foundation, Jefferson Medical College, July 1981 - April 1986
  • Instructor in Medicine Jefferson Medical College, Philadelphia, July 1980 - June 1981

Honors and Awards

  • Pfizer Foundation Prize in final year MBBS examination, 1974
  • E. Merck Gold Medal for Best Outgoing Student in Madurai University, 1974
  • New Investigator Award from National Institute of Health, 1981-1984
  • Established Investigator Award from American Heart Association, 1984-1989
  • Deans Award for excellence in Teaching, University of Texas Houston, 2001

Professional Organization Memberships

  • Member, American Society of Clinical Investigation
  • Member, American Society for Biochemistry and Molecular Biology
  • Fellow, American College of Physicians
  • Member, Royal College of Physicians of United Kingdom
  • Member, American Federation for Medical Research
  • Member, American Society of Hematology
  • Fellow, Council on thrombosis, American Heart Association
  • Association of American Physicians

Representative Publications

  • Gushiken FC, Le A,. Arnett FC and Thiagarajan P . Polymorphisms of b 2-glycoprotein I: Phospholipid binding and multimeric structure. Thrombosis Research. 108:175-80, 2003
  • Borthakur B, Cruz MA, Dong JF, McIntire L, Li F, Lopez J and Thiagarajan P. Sulfatides Inhibit Platelet Adhesion to the von Willebrand Factor A1 Domain under in Flowing Blood Conditions. J of Thrombosis and Hemostasis 1: 1288-95, 2003
  • Merten, Motamedy S, Ramamurthy S, Arnett, F. C. Thiagarajan P. Sulfatides: Targets for Antiphospholipid Antibodies. Circulation 108:2082-7, 2003
  • Le A, Dasgupta S, Planque S, Paul S, Thiagarajan P. The Kringle 2 Domain of Prothrombin as the Target for Antiprothrombin Antibodies in Lupus: Characterization from a V Gene Phage Display Library. Biochemistry 43: 4047-54, 2004
  • Karle S, Planque S, Nishiyama Y, Taguchi H, Zhou YX, Salas M, Lake D, Thiagarajan P , Arnett F, Hanson CV, Paul S. Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. AIDS . 18(2):329-31, 2004
  • Guchhait P, López JA , and Thiagarajan P. Characterization of Autoantibodies against Sulfatide from a V-Gene Phage-Display Library Derived from Patients with Systemic Lupus Erythematosus. J immunol Methods 295:129-3, 2004
  • Conde ID, Nabil F; Tonda R, Thiagarajan P , López, JA, Kleiman NS : Effect of P-selectin on phosphatidylserine exposure and surface-dependent thrombin generation on monocytes. Arteriosclerosis, Thrombosis and Vascular Biology 25:1065-70, 2005
  • Conde ID, Shrimpton, CN, Thiagarajan P, Lopez JA: Tissue factor-bearing microvesicules arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 106:1604-11, 2005
  • Dasgupta SK, Thiagarajan P : The role of lactadherin in the phagocytosis of phosphatidylserine-expressing sickle red blood cells by macrophages. Haematologica /The Hematology Journal 90: 1267-68, 2005
  • Dasgupta SK, Guchhait P, Thiaga raja n P : Lactadherin Binding and Phosphatidylserine Expression on Cell Surface - Comparison with Annexin A5. Translation Research: J Lab Clin Med 148(1):19-25, 2006
  • Vijayan KV, Liu Y, Souza S, Thiagarajan, P , Bray PF. Fibrinogen and prothrombin binding is enhanced to the Pro33 isoform of purified integrin ?IIb?3 . J of Thrombosis and Hemostasis 4:905-6, 2006
  • Dasgupta SK, Thiagarajan P. Inhibition of thrombin activity by prothrombin activation fragment 1.2. J Thromb Thrombolysis. ;24(2):157-62. 2007
  • Conde ID, Bharwani LD, Dietzen DJ;, Pendurthi U, Thiagarajan P, José A. López Microvesicle-Associated Tissue Factor and Trousseau's Syndrome. J of Thrombosis and Hemostasis 70-4, 2007
  • Guchhait P, Dasgupta SK, Le A, Yellapragada S, López, JA, Thiagarajan P. Lactadherin Mediates Sickle Cell Adhesion to Vascular Endothelial Cells in Flowing Blood. Hematologica /The Hematology Journal 92 : 1266-7, 2007
Perumal Thiagarajan, M.D.

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