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Pathology & Immunology

Houston, Texas

Pathology and Immunology
Pathology & Immunology
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Faculty

H. Daniel Lacorazza, Ph.D.Associate Professor

Education

  • Licentiate in Biochemistry (Bachelor's and Master's degree in Science), School of Biochemistry, University of Buenos Aires, Argentina
  • Ph.D. (graduated with honors), School of Biochemistry, University of Buenos Aires, Argentina

Post-doctoral Training

  • Visiting Fellow, National Institutes of Health (NEI/LI), Bethesda. Gene therapy using ex-vivo retroviral gene transfer and transplantation
  • Research Fellow, Immunology Program, Memorial Sloan Kettering Cancer Center, New York. Development and function of T cells
  • Senior Research Scientist, Laboratory of Molecular Aspects of Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York. Role of the transcription factor MEF/ELF4 in immunity and hematopoiesis

Area of Interest

  • Experimental Hematopoiesis: maintenance of hematopoietic stem cells
  • Developmental Immunology: T cell development and function

Current Position

  • Associate Professor of Pathology and Immunology

Other Positions

  • Faculty, Immunology Program
  • Faculty, Translational Biology and Molecular Medicine (TBMM) Program

Honors and Awards

  • The Howard Temin Award, National Cancer Institute, National Institutes of Health
  • The Moran Foundation Award, Baylor College of Medicine
  • Junior Faculty Seed Fund Award, Baylor College of Medicine
  • Lauri Strauss Leukemia Foundation award
  • The Dan L. Duncan Cancer Center, NCI Development Fund Pilot Project

Professional Organization Memberships

  • Associate Member, The Dan L. Duncan Cancer Center
  • Associate Member, Stem Cell and Regenerative Medicine (STaR) Center
  • Associate Member, Texas Gulf Coast Digestive Disease Center
  • Member of the American Society of Hematology since 2003
  • Member of the National Eye Institute Laboratory
  • of Immunology Clinical Branch Alumni Association

Representative Publications

  • Lacorazza, H.D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J., and Nimer, S. The transcription factor MEF (ELF4) regulates the quiescence of primitive hematopoietic cells. Cancer Cell (2006) 9, 175-187. Featured Article on the Cover
  • Lacorazza, H.D., Miyazaki, Y., Di Cristofano, A., Deblasio, T., Hedvat, C., Cordon-Cardo, C., Mao, S., Zhang, J., Pandolfi, P.P., and Nimer, S.D. The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer Cells and NK-T Cells. Immunity. 2002, 17: 437-449. Featured Article on the Cover
  • Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nature Immunology. 2002 May; 3(5): 483-8
  • Lacorazza, H.D., Porritt, H., and Nikolic-Zugic, J. Dysregulated expression of preTα? reveals the opposite effects of pre-TCR at successive stages of T cell development. Journal of Immunology 2001, 167:5689-5696
  • Lacorazza, H.D., Tucek, C., Vasovic, L., Remus, K., Nikolic-Zugic, J. Premature TCRαβ expression and signaling in pre-thymocytes impair thymocyte expansion and partially block their development. Journal of Immunology 2001, 166:3184-3193
  • Lacorazza, H.D., Flax, J., Snyder, E., and Jendoubi, M. Expression of human β-hexosaminidase α-subunit gene in mouse brains upon engraftment of transduced progenitor cells. Nature Medicine 1996; 2 (4), 424-429

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