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Pathology & Immunology

Houston, Texas

Pathology and Immunology
Pathology & Immunology
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Faculty

Dean P. Edwards, Ph.D.Professor

Education

  • Graduate: Medical College of Georgia, School of Graduate Studies Department of Endocrinology, Augusta, GA, Ph.D. Endocrinology, 1971-1976
  • Undergraduate: Ohio University, B.S. Zoology, 1965-1969 Athens, Ohio

Post-doctoral Training

  • Postdoctoral Fellowship, Dr. William McGuire (mentor), Department of Medicine/Oncology, University of Texas Health Science Center, San Antonio, Texas, 1977-1980

Specialty

  • Endocrinology

Area of Interest

  • Research: Steroid hormone receptors, molecular mechanism of action and their role in breast cancer and other endocrine disorders.

Current Position

  • Professor

Professional Positions Held

  • Professor, Departments of Molecular and Cellular Biology and Pathology, Baylor College of Medicine, Houston, Texas, 2005-present
  • Professor (tenure), Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado, 1996-2005
  • Associate Professor (tenure), Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado, 1990-1996
  • Assistant Professor, Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado, 1985-1990
  • Research Assistant Professor, Department of Medicine/Oncology, University of Texas Health Science Center, San Antonio, Texas, 1982-1984
  • Instructor of Medicine, Department of Medicine/Oncology, University of Texas Health Science Center, San Antonio, Texas, 1980-1982

Other Positions

  • Director, Interdepartmental Molecular Biology Program,University of Colorado Health Sciences Center, Denver, Colorado, 2000-2005
  • Dan L. Duncan Cancer Center at Baylor College of Medicine, Director: Recombinant Protein Expression/Proteomics Core, 2005-Present
  • Dan L. Duncan Cancer Center at Baylor College of Medicine, Associate Director Research Infrastructure, 2006-Present

Honors and Awards

  • Distinguished Alumnus Award, Medical College of Georgia, School of Graduate Studies, May 1996
  • Dean's Mentorship Award, University of Colorado Health Sciences Center, May 2000

Professional Organization Memberships

Journal editorial boards:

  • Breast Cancer Research and Treatment, 1986-Present
  • Molecular Endocrinology, 1993-1997, 1999-2003
  • J. Steroid Biochemistry and Molecular Biology, 1994-Present
  • Steroids, 1999-Present
  • Endocrinology, 2007-Present
  • Professional Societies

Membership

  • Endocrine Society
  • American Association for Cancer Research
  • American Association for the Advancement of Science

Elected Positions

  • Annual Meeting Steering Committee, Endocrine Society, 2003-2006
  • Associates Council - Endocrine Society, 1998-2000

Representative Publications

  • Buser, A.D., Gass Handel, E.K., Wyszomierski, S.L., Doppler, W., Leonhardt, S.A., Schaack, J., Rosen, J.M., Watkin, H., Anderson, S.M., and Edwards, D.P. Progesterone receptor repression of prolactin/Stat5-mediated transcription of the β-casein gene in mammary epithelial cells. Mol. Endocrinol., (In press, 2006).
  • Roemer, S.C., Sherman, L., Donham, D., Edwards, D.P., and Churchill, M.E.A. Crystal structure of the progesterone receptor DNA binding domain reveals DNA interactions with the minor groove flanking the core progesterone response element. (In press, 2006.)
  • Wardell, S.E., Sherman, L., Kwok, S.C., Hodges, R.S., and Edwards, D.P. Regulation of the amino terminal transcription activation domain of progesterone receptor by a co-factor-induced protein folding mechanism. Mol. Cell. Biol., 25:8792-8808, 2005
  • Edwards, D.P. Regulation of signal transduction pathways by estrogen and progesterone. In: Annual Review of Physiology 67:335-376, 2005
  • Wardell, S.E., and Edwards, D.P. Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators. Seminars in Reproductive Medicine 23:9-21, 2005.
  • Narayanan, R., Edwards, D.P., and Weigel, N.L. Human progesterone receptor displays cell cycle dependent changes in transcription activity. Mol. Cell. Biol. 25:2885-2898, 2005.
  • Narayanan, R., Adigun, A.A., Edwards, D.P., and Weigel, N.L. Cyclin dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/cdk2 as a progesterone receptor for coactivator. Mol. Cell. Biol. 25:264-277, 2005.
  • Melvin, V.S., Harrell, C., Adelman, J.S., Kraus, W.L., Churchill, M.E.A., and Edwards, D.P. The role of the carboxyl terminal extension (CTE) of the estrogen receptor α and β DNA binding domain in DNA binding and interaction with HMGB. J. Biol. Chem. 279:14763-14771, 2004.
  • Wardell, S.E., Boonyaratanakornkit, V., Adelman, J.S., Aronheim, A., and Edwards, D.P. Jun dimerization protein-2 functions as a progesterone receptor N-terminal coactivator. Mol. Cell Biol. 22:5451-5466, 2002.
  • Melvin, V.S., Roemer, S., Churchill, M., and Edwards, D.P. The carboxyl terminal extension (CTE) of the DNA binding domain of steroid receptors determines interaction with and functional response to HMGB. J. Biol. Chem. 277:25115-15124, 2002.
  • Press, M., Spaulding, B., Groshen, S., Kaminsky, D., Hagerty, M., Sherman, L., Christensen, K., and Edwards, D.P. Comparison of different antibodies for detection of progesterone receptor in breast cancer. Steroids 67:799-813, 2002.
  • Schultz, J.R., Loven, M.A., Melvin, V., Edwards, D.P. and Nardulli, A.M. Differential modulation of DNA conformation by estrogen receptors α and β. J. Biol. Chem. 277:8702-8707, 2002.
  • Boonyaratanakornkit, V., Porter, M., Ribon, V., Sherman, L., Anderson, S.A., Miller, W.T., Edwards, D.P. Progesterone receptor contains a proline rich sequence in the amino terminus that directly interacts with SH3 domains and activates Src family tyrosine kinases. Mol. Cell 8:269-280, 2001.
  • Doppler, W., Windegger, M., Tomassi, J., Lechner, J., Rusconi, S., Cato, A.C.B., Almlöf, Lidén, J., Okret, S., Gustafsson, J-Å., Richard-Foy, H., Starr, D.B., Klocker, H., Edwards, D., Soratroi, C. Expression level dependent contribution of glucocorticoid receptor domains for functional interaction with STAT5. Mol. Cell Biol. 21:3266-3279, 2001.
  • Knotts, T.A., Orkiszewski, R.S., Cook, R.G., Edwards, D.P., Weigel, N.L. Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. J. Biol. Chem. 276:8475-8483, 2001.

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