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Pathology & Immunology

Houston, Texas

Pathology and Immunology
Pathology & Immunology
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Faculty

Dolores Hildegard Lopez-Terrada, M.D., Ph.D.Professor

Education

  • M.D., Ph.D. Universidad de Valencia, Spain

Internship

  • Facultad de Medicina de Valencia, Universidad de Valencia, Spain

Residency

  • Baylor College of Medicine

Fellowship

  • Baylor College of Medicine

Post-doctoral Training

  • Postdoctoral Research Fellow, Childrens Hospital Los Angeles, USC School of Medicine.

Specialty

  • Anatomic Pathology
  • Molecular Genetic Pathology

Board Certification

  • Anatomic Pathology
  • Molecular Genetic Pathology

Area of Interest

  • Biology and molecular genetics of childhood and adult cancer
  • Molecular genetics of Pediatric Small Round Cell Tumors, Leukemias and Lymphomas
  • Molecular Genetics of pediatric liver tumors (hepatoblastoma)
  • Applications of molecular genetics techniques to the diagnosis and prognosis of pediatric neoplasms and sarcomas
  • Gene expression determinations in pediatric undifferentiated tumors and other malignancies.

Current Position

  • Professor Department of Pathology & Immunology, Baylor College of Medicine, September 2012 (Associate Professor, Department of Pathology & Immunology, Baylor College of Medicine, May 2009)
  • Director of the Hematopathology and Cancer Cytogenetics at TCH, since November 2012
  • Adjunct Assistant Professor at the University of Texas MD Anderson Cancer Center, Department of Molecular Genetic Technology since Sept. 1st 2006
  • Attending Pathologist, Texas Children's Hospital, since July 1999
  • Director of the Molecular Oncology Laboratory, at TCH, since July 1999

Professional Positions Held

  • Assistant Professor of Pathology at the Department of Pathology USC School of Medicine
  • Director of the Molecular Cytogenetics and FISH Laboratory, Molecular Pathology Section at the Department of Pathology, Childrens Hospital Los Angeles, University of Southern California

Other Positions

  • Appointed Steering Committee member, Molecular Genetic Technology Program, The University of Texas M.D. Anderson Cancer Center School of Health Sciences, since 2005
  • Appointed Children's Oncology Group pathologist, AAML0532 , Treatment of Transient Myeloproliferative Disorder in Children with Down Syndrome, Groupwide Phase III Study

Professional Organization Memberships

  • European Society of Pathology since 1989
  • International Academy of Pathology (European and United States/Canadian Divisions) since 1990
  • Association for Molecular Pathology since 1994
  • American Society of Clinical Pathologists since 1996
  • Texas Society of Pathologists since 1996
  • Houston Society of Clinical Pathology since 1996
  • Society for Pediatric Pathology since 1999
  • Fellow of the College of American Pathologists since 2003
  • Children's Oncology Group since 2004

Representative Publications

  • Selected Book Chapters and Invited Reviews
  • López-Terrada, D. and Finegold, M. J. "Tumors of the Liver", In Pediatric Gastrointestinal Disease, Pathophysiology, Diagnosis, Management, 6fth edition., chapter 40, Eds: Walker, Press, 2013. (in preparation)
  • Lopez-Terrada, D."Hepatobilitary system and pancreas" In: Essentials of Surgical Pediatric and Perinatal Pathology Cohen and Scheimberg Eds. Cambridge Press (in press)
  • López-Terrada, D. and Finegold, M. J. "Tumors of the Liver", In Liver Disease in Children, 4th edition. Eds: Frederick J Suchy and Ronald J. Sokol and William F. Balisteri. Cambridge University Press, 2012
  • López-Terrada, D. "Hepatoblastoma: new insights into the biology of embryonal tumors of the liver", In: Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine, Ed. Mackinnon, Alexander, Humana Press. 2012
  • Zimmermann, A.and López-Terrada, D. "Pathology of Pediatric Liver Tumors" in Pediatric Liver Tumors. Eds. Zimmermann, Perilongo, Malagolowkin, Von Schweinitz. Springer Verlag Press, Berlin, 2011
  • Rushton, J. and López-Terrada, D. "Molecular and genetic basis of childhood cancer" Chapter 9, In: Translational Pathology of Early Cancer. Eds Srivastava and Grizzle. Springer Verlag Pres, New York, 2011
  • Selected Per Review Articles
  • Malouf, G.; Monzon, F.; Couturier, J.; Molinié, V.; Escudier, B.; Camparo, P.; Su, X.; Yao, H.; Tamboli, P.; Lopez-Terrada, D.; Picken, M.; Varella-Garcia, M.; Multani, A.; Pathak, S.; Wood, C. and Tannir, N. " Genomic Heterogeneity of Translocation Renal Cell Carcinoma" submitted to Clinical Cancer Research (accepeted July 2013)
  • Warren, M; Weindel, M.; Ringrose, J.; Venable, C.; Reyes, A.; Pulivarthi, R.; Chintagumpala, M.; Hicks, J.M.; Lopez-Terrada, D. and Lu, X-Y. " Integrated multimodal genetic testing of Ewing Sarcoma- A Single Institute Experience" Human Pathology (accepted January 2013)
  • Wang WL, Katz D, Araujo DM, Ravi V, Ludwig JA, Trent JC, Patel SR, Lin PP, Guadagnolo A, Lòpez-Terrada D, Dei Tos AP, Lewis VO, Lev D, Pollock RE, Zagars GK, Benjamin RS, Madewell JE, Lazar AJ. Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy. Clin Sarcoma Res. 2012 Dec 29;2(1):25. [Epub ahead of print]
  • López-Terrada, D.; Ranganathan, S.; Fabre, M; Alaggio, R.; De Davila, M. T.; Tanaka, Y.; Leuschner, I, Meyers, R.; Czauderna P. ; Malogolowkin, M.; Katzenstein, H.; Hiyama E.; Zimmermann, A and Finegold, M. J. "Towards an International Pediatric Liver Tumors Consensus Classification: Preceedings of the Los Angeles International Pathology Pediatric Liver tumors Symposium". (accepted in Modern Pathology, pending publication August 2013)
  • Argyris PP, Reed RC, Manivel JC, Lopez-Terrada D, Jakacky J, Cayci Z, Tosios KI, Pambuccian SE, Thompson LD, Koutlas IG. "Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature." Head Neck Pathol. 2012 Sep 8
  • Wang WL, Patel NR, Caragea M, Hogendoorn PC, López-Terrada D, Hornick JL, Lazar AJ. "Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma." Mod Pathol. 2012 Oct;25(10):1378-83. doi: 10.1038/modpathol.2012.97. Epub 2012 Jul 6
  • Wang WL, Evans HL, Meis JM, Liegl-Atzwanger B, Bovee JV, Goldblum JR, Billings SD, Rubin BP, López-Terrada D, Lazar AJ., "FUS rearrangements are rare in 'pure' sclerosing epithelioid fibrosarcoma.". (Accepted in Modern Patholology 2012 Mar 2)
  • Horton, T. M., Sheehan, A.M., Lopez-Terrada,D.; Hutchison, R. E., Narendra, S., Wu, M-F. and Liu, H. "Analysis of NF-kB pathway proteins in pediatric Hodgkin lymphoma: correlations with EBV status and clinical outcome: A Children's Oncology Group (COG) Study," Lymphoma, accepted Nov 2012
  • King L, López-Terrada D, Jakacky J, McCarville MB, Spunt SL, Bridge JA, Bahrami A. Primary Intrathoracic Dermatofibrosarcoma Protuberans. Am J Surg Pathol. 2012 Oct 26
  • Zhang, P.; Bill, K.; Liu, J.; Young, E.; Peng, T.; Bolshakov, S.; Hoffman, A.; Song, Y.; Demicco, E.; Lopez-Terrada, D.; Creighton, C.; Anderson, M.; Lazar, A.; Calin, G.; Pollock, R. and Lev, D. "MiR-155 is a liposarcoma tumor oncogene targeting casein kinase 1α (CK1α) and enhancing β-catenin signaling" (accepted in Cancer Research Feb 2012)
  • DeLario, M.; Sheehan, A.; Ataya, R.; Bertuch, A.; Vega, C.; Webb, C.R.; López-Terrada, D.; Venkateswaran, L. "Primary Myelofibrosis in Children" (accepted for publication in the American Journal of Hematology, January 2012)
  • Shvartsbeyn, M., Lazar MD, A.J.F; López-Terrada, D.and Meehan, S.M., "Dermatofibrosarcoma Protuberans: two cases with an unusual cystic component, with demonstration of COL1A1-PDGFb rearrangement" J Cutan Pathol. 2012 Mar;39(3)
  • Horton, T. M.; Sheehan, A. M.; López-Terrada, D.; Hutchison, R.; Narendra, S.; Wu, M. F.; Lu, H. and Chen, L. "Coordinate Regulation of NF-B Subunit Expression in Rapid-Early-Responders and EBV-Negative Hodgkin Lymphoma Patients by Tissue Microarray Analysis" (Submitted to Modern Pathology)
  • Bien-Willner, G. A.; López-Terrada, D.; Bhattacharjee, M.B.; Patel, K.; Stankiewicz, P.; James R. Lupski, J.R.; Pfeifer, J.; and Perry, A.. "Early Recurrence in Standard Risk Medulloblastoma Patients with the Common idic(17)(p11.2) Rearrangement" (Accepted, Neuro-Oncology March 2012)
  • Wang, W-L; Nero, C.; Pappo, A. ; Lev, D.; Lazar, A. J.; López-Terrada, D. "CTNNB1 Genotyping and APC Screening in Pediatric Desmoid Tumors: A Proposed Alogrithm" Pediatr Dev Pathol. 2012 Feb 28. [Epub ahead of print]
  • Doyle, L. A.; Wang, W.L; Dal Cin, P.; Lopez-Terrada, D.; Mertens, F.; Lazar, A.J.F.; Fletcher, C.D.M. and Hornick, J. L. "MUC4 is a sensitive marker for Sclerosing Epitheliod Fibrosarcoma: association with FUS rearrangement." (accepted, American journal of Surgical Pathology March 2012)
  • López-Terrada, D. and Zimmermann, A. " Current issues and controversies in the classification of Pediatric Hepatocellular Tumors" Pediatric Blood and Cancer (accepted for publication, Pediatric Blood and Cancer Nov 2011)
  • Mariño-Enríquez A, Wang WL, Roy A, López-Terrada D, Lazar AJ, Fletcher CD, Coffin CM, Hornick JL. "Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK". Am J Surg Pathol. 2011 Jan;35(1):135-44
  • Kesserwan, C.; Sokolic, R.; Cowen, E.;Garabedian, E.; Pittaluga, S.; Baird, K.; López-Terrada, D.; Bridge, J.; Wayne, A.; Candotti, F. " Multicentric Dermatofibrosarcoma Protuberans in Patients with Adenosine Deaminase-Deficient Severe Combined Immune Deficiency" Journal of Allergy and Clinical Immunology. 2011 Dec 6. [Epub ahead of print]
  • Chavan, R. S.; Patel, M. S.; Roy, A.; Parsons, D. W. and López-Terrada, D. H. " Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma" Pediatr Blood Cancer. 2011 Dec 19. [Epub ahead of print]
  • Steelman C, Katzenstein H, Parham D, Stockwell C, Ricketts R, Abramowsky C, Bridge JA, Sorensen PH, Kenney B, Olson T, Igbokwe A, López-Terrada, D, and Shehata B. "Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis". Fetal Pediatr Pathol. 2011;30(5):329-37. Epub 2011 Aug 15
  • Powers M, Zhang W, López-Terrada D, Czerniak BA, Lazar AJ. "The molecular pathology of sarcomas". Cancer Biomark. 2011;9(1-6):475-91
  • Swaby, M. G.; Evans, H. L.; Fletcher, C. D.; Prieto, V. G.; Patel, K., Lev D. C.; Lòpez-Terrada, D.; Lazar, A. J.; Wang, W. L.. " Dermatofibrosarcoma Protuberans With Unusual Sarcomatous Transformation: A Series of 4 Cases With Molecular Confirmation.", Am J Dermatopathol. 2011 Jun;33(4):354-360
  • Rushton J, López-Terrada D."Molecular and genetic basis of childhood cancer.Cancer Biomark. 2011;9(1-6):211-34
  • Weaver, J.; Rao, P.; Goldblum, J. R.; Joyce, M. J.; Turner, S. L.; Lazar, A. J. F.; López-Terada, D.; Tubbs R. R. and Rubin, B. R.. " Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol 2010 23: 1301-1306; advance online publication, May 21, 2010
  • Igbokwe, A. and López-Terrada, D. "Molecular Diagnostic Testing in Solid Tumors" Special Section of the Archives of Pathology and Laboratory Medicine commemorating the 90th aniversary of the Texas Society of Pathology Arch Pathol Lab Med. 2011 Jan;135(1):67-82
  • Peng, T.; Zhang, P.; Liu, J.; Nguyen, T.; Bolshakov, S.; Belousov, R.; Young, E. D.; Wang, X.; Brewer, K.; López Terrada, L.; Oliveira, A. M.; Lazar, A. J.; Lev, D. "An experimental model for the study of well differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors" Lab Invest. 2010 Nov 8. [Epub ahead of print]
  • Been, L.; Olar, A.; Powers, M.P.; López-Terrada, D.; Laucirica, R. "Myxoid liposarcoma: A case report of a sentinel metastasis to the parotid gland with molecular confirmation" accepted Diagnostic Cytopathology, August 2010
  • Wang WL, Patel KU, Coleman NM, Smith-Zagone MJ, Ivan D, Reed JA, López-Terrada D, Lazar AJ, Prieto VG. "COL1A1:PDGFB chimeric transcripts are not present in indeterminate fibrohistiocytic lesions of the skin". Am J Dermatopathol. 2010 Apr;32(2):149-53
  • Steelman, C. K.; Katzenstein, H. M.; Parham, D. M.; Stockwell. C. A.; Ricketts, R. R.; Abramowsky, C. A.; Bridge, J. A.; Sorensen, P. H. B; Kenney, B. D.; Olson, T. A.; Igbokwe, A.; López-Terrada, D. H.; Shehata, B. M.. " Unusual Presentation of Congenital Infantile Fibrosarcoma in Seven Infants with Molecular-Genetic Analysis" accepted in Fetal and Pediatric Pathology, July 2010
  • Powers, M.P.; Wang, W.L.; Hernandez, V. S.; Patel, K.. Lev, D. C.; Lazar, A. J.; López-Terrada, D. " Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay". Mod Pathol 2010 23: 1307-1315; advance online publication, June 25, 2010
  • Rutkowski, P.; Glabbeke M. V.; Rankin, C. J.; Ruka, W.; Rubin, B. P.; Debiec-Rychter, M.; Lazar, A.; Gelderblom, H.; Sciot, R.; López-Terrada, D.; Hohenberger, P; van Oosterom, A. T.; Schuetze. S. " Imatinib mesylate in advanced dermatofibrosarcoma protuberans (DFSP) - pooled analysis of two phase II clinical trials" J Clin Oncol. 2010 Mar 1. [Epub ahead of print]
  • Lazar, A.J.; Lahat, G.; Myers, S.E.; Smith, K.D.; Zou, C.; Wang, W.L.; López-Terrada, D.; Lev, D.: "Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray". Histopathology. 2009 Dec;55(6):750-5
  • López-Terrada, D.; Knowles, B.B.; Finegold, M. J. "HepG2 cell line is derived from a hepatoblastoma and not from a hepatocellular carcinoma". Hum Pathol. 2009 Oct;40(10):1512-5
  • Wang, W-L.; Mayordomo, E; Zhang, W.; Hernández, V.; Tuvin, D.; Garcia, D.; Lev, D.; Lazar, A. J. and López-Terrada, D. " Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in Clear Cell Sarcoma (Melanoma of Soft Parts)" Mod Pathol. 2009 Sep;22(9):1201-9
  • Downs-Kelly, E.; Shehata, B. M.; López-Terrada, D.; Weaver, J.; Patel, R.M.; Hartke, M.; Tubbs, R. R.; Skacel, M. and Goldblum, J. R. ". Diagn Mol Pathol. 2009 Sep;18(3):138-43
  • Zhang, W. W.; Habeebu, S.; Sheehan, A. M.; Naeem, R.; Dreyer, Z. E.; López-Terrada, D."Molecular monitoring of t(8;13) stem cell leukemia/lymphoma syndrome in an infant". J Pediatr Hematol Oncol. 2009 Nov;31(11):879-83
  • Kesserwan, C.; Sokolic, R.; Cowen, E.; Garabedian, E.; Pittaluga, S.; Baird, K.; López-Terrada, D.; Issekutz, A.; Bridge, J.; Wayne A. and Candotti, F. "Dermatofibrosarcoma protuberans (DFSP) in six patients with ADA-SCID" Journal of Clinical Oncology, Vol 27, No 15S (May 20 Supplement), 2009: 10570
  • Adesina AM.; López-Terrada, D.; Wong, K.K.; Gunaratne, P.; Nguyen, Y.; Pulliam, J.; Margolin, J.; Finegold, M.J. "Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways" Hum Pathol. 2009 Jun;40(6):843-53. Epub 2009 Feb 5
  • López-Terrada, D.; Gunaratne, P. H.; Pulliam, J. F.; Adesina, A.; Judith F. Margolin J. F.; Finegold, M. J. "Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors" Hum Pathol. 2009 Jun;40(6):783-94. Epub 2009 Feb 5
  • Lazar, A. J. F.; Tuvin, D.; Hajoibashi, S.; Habeebu, S.; Bolshakov, S.; Mayordomo-Aranda, E.; Warneke, C. L.; López-Terrada, D.; Pollock, R. E.; Lev, D. " Specific Mutations in CTNNB1, the Gene Encoding ß-catenin, Correlate with Local Recurrence in Desmoid Fibromatosis" Am J Pathol. 2008 Nov;173(5):1518-27. Epub 2008 Oct 2
  • Patel, K; López-Terrada, D. Dermatofibrosarcoma Protuberans. Atlas Genet Cytogenet Oncol Haematol. August 2008. URL:http://AtlasGeneticsOncology.org/Genes/DermFibroSarcProt ID5059.html
  • Fong, YE; López-Terrada, D and Zhai, Q. Primary Ewing's/primitive neuroectodermal tumor of the vulva. Hum Pathol. 2008 Oct;39(10):1535-9. Epub 2008 Jul 7
  • Wang , W-L.; Mayordomo E.; Czerniak B. A.; Abruzzo, L. V.; Dal Cin, P.; Araujo, D. M.; Lev, D. C.; Dolores López-Terrada, D. and Lazar, A. J."Fluorescence In-situ Hybridization (FISH) as a Useful Ancillary Diagnostic Tool for Extraskeletal Myxoid Chondrosarcomas". Mod Pathol. 2008 Jun 27. Epub ahead of print
  • Patel, N. C.;Vilchez, R. A.; Killen D. E.; Zanwar, P.; Sroller, V.; Eldin, K. W.; López-Terrada, D. and Butel, J. S. " Detection of polyomavirus SV40 in tonsils from immunocompetent children". J Clin Virol. 2008 Jun 6, Epub ahead of print
  • Lazar, AJF; Das, P; Korchin, B; Jin, Z; Warneke, CL; Kotlingham, D; PS, P; López-Terrada, D; Pisters, PW; Pollock, RE; Lev, D. Angiogenesis-promoting gene patterns in alveolar soft part sarcoma (ASPS): a highly metastatic tumor with prolonged survival, Clin Cancer Res. 2007 Dec 15;13(24):7314-21
  • Patel, KU; Szabo, SS; Hernandez, VS; Prieto V; Abruzzo, L; Lazar, AJ & López-Terrada, D. Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all DFSP cases when investigated by newly developed multiplex RT-PCR and FISH assays. Hum Pathol. 2008 Feb;39(2):184-93. Epub 2007 Oct 24
  • Curry, CV; Dishop, MK; Hicks, JM; Naeem, R; Reed, JA; López-Terrada, D. Clear cell sarcoma of soft tissue: Diagnostic utility of fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction. Journal of Cutaneous Pathology. 2008 Apr;35(4):411-7
  • Finegold, MJ; López-Terrada, D Bowen, J; Washington, M. K; Qualman, S. J.: Protocol for the Examination of Specimens from Pediatric Patients with Hepatoblastoma, Archives of Pathology and Laboratory Medicine, 131, 520-529, April 2007

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