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Pathology & Immunology

Houston, Texas

Pathology and Immunology
Pathology & Immunology
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Yuko Mori-Akiyama, M.D.

Yuko Mori-Akiyama, M.D.Assistant Professor


  • M.D., Kyoto Prefectural University of Medicine, Kyoto, Japan
  • The University of Texas MD Anderson Cancer Center, Department of Molecular Genetics

Areas of Interest

  • Cell differentiation
  • Intestinal epithelial cell biology

Current Position

  • Assistant Professor of Pathology

Professional Positions Held

  • Assistant Professor of Genetics, The University of Texas MD Anderson Cancer Center

Honors and Awards

  • AACR-AstraZeneca Scholar in Award, American Association for Cancer Research, 2006
  • Keystone Symposia Scholarship Award 2006, Keystone Symposia, 2006
  • FASEB summer research conferences GI tract, Travel Award, 2006
  • The Texas Digestive Disease Center Pilot / Feasibility Award, 2008
  • Sara-Jordan Research Scholar Award, American Gastroenterological Association, 2008

Professional Organization Memberships

  • American Gastroenterology Association, member, 2006 - present
  • Texas Digestive Disease Center, associate member, 2006 - present

Representative Publications

  • Shi Z, Chiang C-I, Mistretta T, Major A, Mori-Akiyama, Y. SOX9 directly regulates IGFBP-4 in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2013, in press.
  • Lee HT, Kim M, Kim JY, Brown KM, Ham A, D'Agati, VD, Mori-Akiyama, Y. Critical role of interleukin-17A in murine intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2013, 304(1):G12-25. doi: 10.1152/ajpgi.00201.2012. Epub 2012 Nov 1.
  • Park SW, Kim, M, Kim JY, Ham A, Brown KM, Mori-Akiyama, Y, Ouellette AJ, D'Agati VD, Lee HT. Paneth cell-mediated multiorgan dysfunction after acute kidney. J. Immunology, 2012 Dec 1;189(11):5421-33. doi: 10.4049/jimmunol.1200581. Epub 2012 Oct 29.
  • Zhao Y, Liang L, Fan Y, Sun S, An L, Shi Z, Cheng J, Jia W, Sun W, Mori-Akiyama, Y, Zhang H, Fu S, Yang. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. J. Cell Signal. 2012 ;24(11):2197-204. Epub 2012 Jun 30. PMID: 22750291.
  • Mori-Akiyama Y, van den Born M, van Es J H, Hamilton S R, Adams H P, Zhang J, Clevers H, de Crombrugghe B. SOX9 is required for the differentiation of Paneth cells in the intestinal epithelium. Gastroenterology, 2007. [PMID: 17681175]
  • Akiyama H, Kamitani T, Yang X, Kandyil R, Bridgewater L C, Fellous M, Mori-Akiyama Y, de Crombrugghe B. The transcriptional factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site. Matrix Biol. 23:499-505, 2005.
  • Akiyama H, Lyons J P, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng J M, Taketo M M, Nakamura T, Behringer R R, McCrea P D, de Crombrugghe B. Interactiuon between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 18:1072-1087, 2004. [PMCID: 406296]
  • Mori-Akiyama Y, Akiyama H, Rowitch D H, de Crombrugghe B. Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc. Natl. Acad. Sci. USA, 100:9360-9365, 2003. [PMCID: 170923]

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