Jimena Giudice, Ph.D.
Started in the lab: August 2011
Funding: Postdoctoral Fellowship, Pew Latin American Fellows Program
Alternative splicing (AS) explains how a relatively limited number of genes gives raise a vast proteomic complexity in higher eukaryotes. AS plays a key role during differentiation and development. During postnatal heart development many physiological changes are associated with dynamic regulation of gene expression. The fetal heart adapts to birth and converts to adult function through transcriptional and posttranscriptional mechanisms, including coordinated AS regulatory networks. The human heart is composed of cardiomyocytes (CM) (<20%), cardiac fibroblasts (CF) (~66%) and surface epithelium and vascular cells. Communication between CF and CM is important early in heart development, but only few investigations have addressed this issue in vivo. My project is focused in the study of splicing and gene expression regulation during heart development specifically in CM and CF. I am interested on events directly regulated by the RNA binding proteins, CELF1 and CELF2, which coordinate a splicing networks through 10-fold down regulation within the first two weeks after birth. I am also interested in the functional consequences of the most important isoform transitions as well as the effect of these transitions and gene expression in the communication between CF and CM.
Elguero B, Gueron G, Giudice J, Toscani AM, De Luca P, Zalazar F, Coluccio Leskow F, Meiss R, Navone N, De Siervi A and Vazquez E. (2012). Heme oxygenase 1 (HO-1) impairs androgen receptor transcription through stat3 signaling in prostate cancer. Neoplasia. In press.
Pistone Creydt V, Fletcher SJ, Giudice J, Bruzzone A, Chasseing NA, Gonzalez EG, Sacca PA and Calvo JC. (2012). Human adipose tissue from normal and tumoral breast regulates the behavior of mammary epithelial cells. Clin Transl Oncol. Jul 19. [Epub ahead of print].
Ferrando M, Gueron G, Elguero B, Giudice J, Salles A, Leskow FC, Jares-Erijman EA, Colombo L, Meiss R, Navone N, De Siervi A and Vazquez E. (2011). Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer. Angiogenesis 14 (4): 467-79.
Rossetti MV, Granata BX, Giudice J, Parera VE and Batlle A. (2008). Genetic and biochemical studies in Argentinean patients with variegate porphyria. BMC Med Genet. 9: 54-70.
Publications in Science Education:
Giudice J and Galagovsky L. (2012). The students create models: the particulate nature of the matter. In "Didáctica de las Ciencias Naturales. El caso de los modelos científicos". Lugar Editorial. Bs As. Chapter 8. 2012. Spanish.
Alí S, Di Giacomo M, Galagovsky L, Gemelli M, Giudice J, Lacolla L, Pepa L and Peralta CP. (2010). Chemistry text books: communication or non communication? Industria y Química 362: 61-64. Spanish.
Giudice J and Alonso M. (2009). Analogies created by the students: instruments to teach the non discontinuous nature of the matter. Enseñanza de las Ciencias VIII: 1736-1739. Spanish.
Giudice J and Galagovsky L. (2008). Teaching students to model the particulate nature of the matter: an approach. REEC. 7 (3): 629-658. Spanish.