Ravi Singh, Ph.D.
Joined the lab: December 2009
Funding: Postdoctoral Fellowship, American Heart Association, Southwest Division
Recent advances in sequencing technologies underscore the importance of post-transcriptional regulation of gene expression especially the role of alternative splicing during development. The coordinated regulation of alternative splicing of genes in heart and skeletal muscle is important for integration of gene programs for normal striated muscle physiology. Misregulation of splicing events of individual genes and splicing factors/pathways contribute to many diseases related to heart and skeletal muscle. I'm broadly interested in understanding the coordination of post-transcriptional processes especially alternative splicing by various RNA binding proteins, splicing factors/pathways. My current project is to identify the role of Rbfox family of RNA-binding proteins during skeletal muscle development.
Singh, R. and Cooper, T. A. (2012) Pre-mRNA splicing in disease and therapeutics. Trends Mol Med. Aug;18(8):472-82.
Singh RK, Tapia-Santos A, Bebee TW, and Chandler DS. Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress. Experimental Cell Research. Exp Cell Res.2009; 315(19):3419-32.
Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC. (2008) NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell. 2008 Nov 4; 14(5): 369-81.
Chandler DS, Singh RK, Caldwell LC, Bitler JL, and Lozano G. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. Cancer Research, 2006,66: 9502-9508.
Ray P, Malik J, Singh RK, Bhatnagar S, Bahl R, Kumar R, Bhan MK. Rotavirus nonstructural protein NSP4 induces heterotypic antibody responses during natural infection in children. J Infect Dis. 2003,187: 1786-93.