Auinash Kalsotra, Ph.D.
In the lab: July 2006 - November 2012
Funding: Postdoctoral Fellowship, Myotonic Dystrophy Foundation; American Heart Association Development Award
Current Position: Assistant Professor, University of Illinois, Urbana-Champaign
Kalsotra, A. and Cooper, T. A. (2011) Functional consequences of developmentally regulated alternative splicing Nature Rev. Genet. 12, 715-729.
Kalsotra, A., Wang, K, Li, P.-F., and Cooper, T. A. (2010) MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development. Genes Dev. 24, 653-658.
Kalsotra, A., Tran, D., Ward, A., Xiao, X., Burge, C.B., Castle, J.M., Johnson, J.C., and Cooper, T.A. (2008) A conserved program of regulated alternative splicing during vertebrate heart development . Proc. Nat'l Acad. Sci. 105, 20333-20338
Castle, J.C., Zhang, C., Shah, J.K, Kulkarni, A.V., Kalsotra, A., Cooper, T.A ., and Johnson, J.M. (2008) Differential expression of 24,426 human alternative splicing events and predicted cis-regulation in 48 tissues and cell lines. Nat. Genet. 40, 1416-1425.
Kalsotra A, Du L, Wang Y, Ladd PA, Kikuta Y, Duvic M, Boyd AS, Keeney DS, and Strobel HW (2008). Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways. FASEB J . 22(2):538-47.
Kalsotra A, Anakk S, Brommer CL, Kikuta Y, Morgan ET, and Strobel HW. (2007). Catalytic characterization and cytokine mediated regulation of Cytochrome P450 4Fs in rat hepatocytes. Arch Biochem Biophys 461(1): 104-112.
Kalsotra A, Zhao J, Anakk S, Dash PK , and Strobel HW. (2007). Brain trauma leads to enhanced lung inflammation and injury: evidence for role of P4504Fs in resolution. J Cereb Blood Flow Metab 27(5): 963-974.
Kalsotra A, and Strobel HW (2006). Cytochrome P450 4F subfamily: at the crossroads of eicosanoid and drug metabolism. Pharmacol Ther 112(3): 589-611.
Kalsotra A, Cui X, Anakk S, Hinojos CA, Doris PA, and Strobel HW. (2005). Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats. Biochem Biophys Res Commun 338(1): 423-431.
Kalsotra A, Turman CM, Kikuta Y and Strobel HW (2004). Expression and characterization of human Cytochrome P450 4F11. Putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol. 199(3):295-304.
Anakk S, Kalsotra A, Kikuta Y, Huang W, Zhang J, Staudinger JL, Moore DD, and Strobel HW (2004). CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. Pharmacogenomics J. 4: 91-101
Kalsotra A, Turman CM, Dash PK and Strobel HW (2003). Differential effects of Traumatic Brain Injury on the Cytochrome P450 System: A perspective into hepatic and renal drug metabolism. J Neurotrauma. 20(12): 1339-50
Kalsotra A, Cui X, Antonovic L, Robida AM, Morgan ET and Strobel HW (2003). Inflammatory prompts produce isoform specific changes in the expression of leukotriene B4 w - hydroxylases in rat liver and kidney. FEBS Lett. 555(2): 236-42
Anakk S, Kalsotra A , Shen Qi, Vu MT, Staudinger JL, Davies P.J and Strobel HW (2003). Genomic characterization and regulation of CYP3a13: Role of xenobiotics and nuclear receptors. FASEB J . 17(12):1736-8.
Cui X, Kalsotra A , Robida AM, Matzilvich D, Moore AN, Boehme CL, Morgan ET, Dash PK and Strobel HW (2003). Expression of cytochromes 4F4 and 4F5 in infection and injury models of inflammation. Biochim, Biophys Acta . 1619, 325-31.
Kalsotra A , Anakk S, Boehme CL and Strobel HW (2002). Sexual dimorphism and tissue specificity in the expression of CYP 4F forms in Sprague Dawley rats. Drug Metab Dispos . 30, 1022-28.
Kalsotra A (2005). Erythromycin mechanism (antibiotic); case #8 in Casefiles: Biochemistry . E Toy, W Seifert Jr., HW Strobel and K Harms (eds), LANGE SERIES by Mcgraw-Hill UK , pps. 107-114
Kalsotra A (2005). Quinolone use (pelvic inflammatory disease); case #9 in Casefiles: Biochemistry . E Toy, W Seifert Jr., HW Strobel and K Harms (eds), LANGE SERIES by Mcgraw-Hill UK , pps. 107-114
Strobel HW, Kalsotra A and Dash PK (2003). Cytochrome P450 4Fs: Response and role following brain trauma, in Cytochrome P450, Biochemistry Biophysics & Drug Metabolism. P Anzenbacher and J Hudecek (eds), MONDUZZI EDITORE : Prague , pps. 107-114