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Path-Immuno - Tom Cooper Lab

Houston, Texas

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Path-Immuno - Tom Cooper Lab
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CELF Proteins

The nomenclature of CELF (pronounced, “self”) proteins is rather confusing. “CELF#” is the approved gene symbol by Human Genome Organization (HUGO) .

CELF proteins contain three RNA binding domains (RNA recognition motifs or RRMs) and a domain of 160-230 residues called the linker or divergent domain that is unique in the database and differs between CELF paralogues. The divergent domain contains regions required for splicing activation and repression that are separate from regions required for RNA binding ( Singh et al. 2004 , Han et al. 2005 .)

Approved

Approved Name

Protein Identity

Location

Accession IDs

Aliases

Gene Symbol

to CELF1

CELF1

CUGBP, Elav-like family member 1

---

11p11

U63289, NM_006560

CUGBP1 CUG-BP, BRUNOL2, hNab50, NAB50, CUGBP, NAPOR, EDEN-BP

CELF2

CUGBP, Elav-like family member 2

78%

10p13

U69546

CUGBP2, BRUNOL3, Etr-3, NAPOR-2

CELF3

CUGBP, Elav-like family member 3

44%

1q21

U80759, NM_007185

BRUNOL1, TNRC4 CAGH4, ERDA4, MGC57297

CELF4

CUGBP, Elav-like family member 4

42%

18q12

AF248651, NM_020180

BRUNOL4

CELF5

CUGBP, Elav-like family member 5

39%

19p13

AF248649, NM_021938

BRUNOL5

CELF6

CUGBP, Elav-like family member 6

46%

15q24

AF425606, NM_052840

BRUNOL6

Table 1: CELF protein nomenclature

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