The Cooper Lab
The recent realization that most human genes generate multiple protein isoforms via alternative splicing has revealed an extensive degree of regulation that remains to be explored.
The Cooper Lab is interested in understanding the mechanisms of this regulation, from how RNA binding proteins regulate splicing of individual pre-mRNAs to the signaling events that coordinate splicing networks during development.
A second major interest in the lab is the pathogenic mechanism of myotonic dystrophy in which disruption of developmentally regulated RNA processing causes primary features of the disease.
The two areas of investigation provide opportunities for synergistic interactions within the lab in which knowledge gained in one area fosters understading in the other.