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Neurology

Houston, Texas

The Cullen Building at Baylor College of Medicine.
Department of Neurology
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James D. Frost, Jr., M.D.

Professor of Neurology and Neuroscience

Medical School

M.D., Baylor College of Medicine, Houston, Texas

Internship

The Methodist Hospital, Houston, Texas

Clinical Fellowship

Clinical Neurophysiology, Baylor College of Medicine, Houston, Texas

Clinical Interests

Clinical neurophysiology. electroencephalography, epilepsy, infantile spasms, sleep disorders

Research Interests

Etiology, pathophysiology and treatment of infantile spasms; development of automated electrophysiological and video techniques for the detection and characterization of epileptic seizures; sleep disorders

Contact Information

James D. Frost, Jr., M.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030

Tel: 713-798-0980
Fax: 713-798-0984
Email:

Journal Publications (Selected out of 109)

  • Haneef Z, Levin HS, Frost JD, Jr, Mizrahi EM. Electroencephalography and quantitative electroencephalography in mild traumatic brain injury. J Neurotrauma. 2013;30(8):653-6. [View journal article]
  • Hrachovy RA, Frost JD, Jr. Infantile spasms. Handb Clin Neurol. 2013;111:611-8. [View journal article]
  • Frost JD, Jr, Lee CL, Le JT, Hrachovy RA, Swann JW. Interictal high frequency oscillations in an animal model of infantile spasms. Neurobiol Dis. 2012;46(2):377-88. [View journal article]
  • Frost JD, Jr, Lee CL, Hrachovy RA, Swann JW. High frequency EEG activity associated with ictal events in an animal model of infantile spasms. Epilepsia. 2011;52(1):53-62. [View journal article]
  • Mitra J, Glover JR, Ktonas PY, Thitai Kumar A, Mukherjee A, Karayiannis NB, et al. A multistage system for the automated detection of epileptic seizures in neonatal electroencephalography. J Clin Neurophysiol. 2009;26(4):218-26. [View journal article]
  • Price MG, Yoo JW, Burgess DL, Deng F, Hrachovy RA, Frost JD, et al. A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with Interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment. J Neurosci. 2009;29(27):8752-63. [View journal article]
  • Guggenheim MA, Frost JD, Jr, Hrachovy RA. Time interval from a brain insult to the onset of infantile spasms. Pediatr Neurol. 2008;38(1):34-7. [View journal article]
  • Lee CL, Frost JD, Jr, Swann JW, Hrachovy RA. A new animal model of infantile spasms with unprovoked persistent seizures. Epilepsia. 2008;49(2):298-307. [View journal article]
  • Hrachovy RA, Frost JD, Jr. The EEG in selected generalized seizures. J Clin Neurophysiol. 2006;23(4):312-32. [View journal article]
  • Karayiannis NB, Mukherjee A, Glover JR, Ktonas PY, Frost JD, Jr, et al. Detection of pseudosinusoidal epileptic seizure segments in the neonatal EEG by cascading a rule-based algorithm with a neural network. IEEE Trans Biomed Eng. 2006;53(4):633-41. [View journal article]

Books and Volumes

  • Frost JD, Jr, Hrachovy RA. Infantile spasms: diagnosis, management, and prognosis. Boston: Kluwer Academic Publishers; 2003.

Book Chapters and Other Publications (Selected out of 42)

  • Hrachovy RA, Frost JD, Jr. Adrenocorticotropic hormone and steroids. In: Engel J, Jr, Pedley TA, editors. Epilepsy - a comprehensive textbook. 2nd ed. Philadelphia: Wolters Kluwer | Lippincott Williams & Wilkins; 2008. p. 1519-1529.
  • Hrachovy RA, Frost JD, Jr. Severe encephalopathic epilepsy in infants: infantile spasms (West syndrome). In: Pellock JM, Bourgeois BFD, Dodson WE, editors. Pediatric epilepsy: diagnosis and therapy. 3rd ed. New York: Demos; 2008. p. 249-268.
  • Hrachovy RA, Frost Jr JD. Infantile spams. In: Chapman K, Roberts C, Rho JM, editors. Pediatric epilepsy case studies: From infancy and childhood through adolescence. Boca Ratan, FL: CRC Press, Taylor & Francis Group; 2008. p. 109-116.
  • Frost JD, Jr, Wise MS. Sleep disorders. In: Rolak LA, editor. Neurology secrets. 4th ed. Philadelphia: Hanley & Belfus, Inc.; 2005. p. 159-192.
  • Frost JD, Jr. EEG in aviation, space exploration, and diving. In: Niedermeyer E, Lopes da Silva F, editors. Electroencephalography: basic principles, clinical applications and related fields. 5th ed. Baltimore: Williams and Wilkins; 2005. p. 683-688.
  • Frost JD, Jr. Sleep disorders. In: Rolak LA, editor. Neurology secrets. 3rd ed. Philadelphia: Hanley and Belfus; 2001. p. 301-308.
  • Hrachovy RA, Frost JD, Jr. Severe encephalopathic epilepsy in infants: West syndrome. In: Pellock JM, Dodson WE, Bourgeois BFD, editors. Pediatric epilepsy: diagnosis and therapy. 2nd ed. New York: Demos; 2001. p. 177-191.
  • Frost JD, Jr. EEG in aviation, space exploration, and diving. In: Niedermeyer E, Lopes da Silva F, editors. Electroencephalography: basic principles, clinical applications and related fields. 4th ed. Baltimore: Williams and Wilkins; 1999. p. 656-659.
  • Frost JD, Jr. Sleep disorders. In: Rolak LA, editor. Neurology secrets. 2nd ed. Philadelphia: Hanley and Belfus; 1998. p. 287-243.
  • Frost JD, Jr. EEG in aviation, space exploration, and diving. In: Niedermeyer E, Lopes da Silva F, editors. Electroencephalography: basic principles, clinical applications and related fields. 3rd ed. Baltimore: William and Wilkins; 1993. p. 615-618.

Poster and Platform Presentations

  • Frost JD, Lee CL, Hrachovy RA, Swann JW. High frequency EEG activity associated with ictal events in the TTX model of infantile spasms. Epilepsia. 2009;50(Suppl 11):28-9.
  • Mizrahi EM, Frost JD, Jr., Friedman DE, Hrachovy RA, Slater JD. Assessment of acute mild traumatic brain injury by quantitative EEG analysis — Mission Connect: Mild Traumatic Brain Injury Translational Research Consortium — The Integrated Clinical Protocol: Neurophysiology Core. Presented at the US Department of Defense, Military Health Research Forum 2009 in Kansas City, Mo. (Aug. 31 - Sept. 3, 2009). [View poster]
  • Lee CL, Antalffy B, Frost JD Jr, Hrachovy RA, Swann JW. Persistent focal neocortical abnormalities in the TTX model of infantile spasms. Epilepsia. 2007;48(Suppl 6):295.
  • Lee CL, Frost JD Jr, Swann JW, Hrachovy RA. Neonatal blockade of cortical or hippocampal activity: A possible model of infantile spasms. Epilepsia. 2006;47(Suppl 4):223-4.
  • Verma A, Mizrahi EM, Frost JD Jr. Vagus nerve stimulation: Correlation of changes in spike morphology with seizure control. Epilepsia. 2001;42(Suppl 7):41.

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