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Neurology - Alzheimers

Houston, Texas

The Cullen Building at Baylor College of Medicine.
Department of Neurology
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A Longitudinal Study of Cognitive and Functional Abilities Using a Neuropsychological Test Battery (NTB)

Enrollment — Closed

What is the purpose of this study?

The purpose of this non-interventional longitudinal study is to examine the psychometric properties of the Neuropsychological Test Battery and to correlate it with other neurocognitive and functional assessments in subjects with mild to moderate Alzheimer's Disease.

Sponsors

Elan Pharmaceuticals

Number of Subjects

The study will involve about 300 participants at 40 centers across the country.

Eligibility Requirements

To be eligible, a patient must:

  • Be between 50 and 85 years old and in good general health
  • Have a diagnosis of mild to moderate Alzheimer's disease
  • Score between 16 and 26 on the Mini-Mental Status Exam
  • Have an informant (who has frequent contact with the subject) who can accompany the patient to the clinic visits and answer questions about daily functioning.

Length of the Study

There are six study visits over a 19-month period.

Study Design

Subjects participating in this study will be asked to come to Baylor College of Medicine's Department of Neurology, located on the 18th floor of Smith Tower at 6550 Fannin. At the initial visit, a consent form explaining the study will be presented. Eligible subjects will be asked questions about their medical history and current medications, and then will be asked to complete a series of neuropsychological tests. These tests will include tasks of verbal and visual memory, attention and concentration, visual-spatial perception, language functioning, and manual dexterity. Subjects will also be given a brief physical exam (including vital signs) and neurological assessment. The first clinic visit will take about three hours. Participants will be asked to return in one month for repeat memory testing and functional assessments. The second visit will take about three hours. Visit 3 will be occur three months later and this visit will take about two hours. Visit 4 will take place three months later and will last three hours long. Visit 5 will happen six months later and will take three hours. Visit 6 will take place six months later and will take three hours.

For more information

Contact: Aline Hittle at Baylor College of Medicine
Tel: 713-798-5325
E-mail:

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