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Neurology - Alzheimers

Houston, Texas

The Cullen Building at Baylor College of Medicine.
Department of Neurology
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Alzheimer's Disease Neuroimaging Initiative (ADNI)

Enrollment — Closed

Purpose of the study

The Alzheimer's Disease Neuroimaging Initiative will test whether serial magnetic resonance imaging, positron emission tomography, other biological markers, and clinical and neuropsychological assessment can be used together to measure progression in MCI and AD. Neuroimaging research suggests that PET and MRI may be a more precise tool in assessing disease progression than traditional neuropsychological assessments. Standardizing the way neuroimaging is done would make it easier for researchers to compare studies, develop new treatments and monitor their effectiveness.

Sponsors

National Institutes of Health and private funding.

Number participating

The study will involve about 800 people at 50 centers across the country.

Eligibility

There will be three groups: normal, MCI, and early AD. Memory testing will be performed to assess memory functioning. There are group specific requirements. For all three groups, a person is eligible is they:

  • Are persons between 55 and 90 in good general health
  • Have an informant, who has frequent contact, and who is available to accompany them to all visits

Length of the study

Subjects in the normal and MCI group will be followed for three years. Subjects in the early AD group will be followed for two years.

Costs

There are no costs associated with this study except for parking costs when you come for study visits.

Study design

All three groups will have blood and urine samples taken at Baseline. Physical and neurological examinations will also be performed. Some participants will also have PET imaging done in addition to a MRI. The schedule and number of visits will vary by group. Normal: Screening/Baseline and at 6, 12, 24, and 36 months. There will be a MRI at every visit. MCI: Screening/Baseline and at 6, 12, 18, 24, 30, and 36 months. There will be a MRI at all visits except at month 30. AD: Screening/Baseline and at 6, 12, 18, and 24 months. There will be a MRI at all visits except at month 18.

For more information

Contact: Munir Chowdhury at Baylor College of Medicine
Tel: 713-798-5328
E-mail:

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