Regulation of HIV Gene Expression
The Rice laboratory studies how gene expression is regulated in HIV - the virus that causes AIDS. The major focus of our research is on the HIV Tat protein, which is essential for HIV transcription, and on two cellular factors, cyclin T1 and Cdk9, which are necessary for Tat function. We are investigating how cyclin T1 and Cdk9 are regulated in the two cell types that HIV infects - CD4+ T cells and macrophages.
The cyclin T1 subunit of the HIV Tat cofactor TAK/P-TEFb is transiently induced during macrophage differentiation.
(Images by C. Herrmann)