Barbara W. Trautner, M.D., Ph.D.
Department of Medicine, Section of Infectious Diseases
Associate Chief of Medicine, Michael E. DeBakey VAMC
The overall goal of my research is to develop new strategies for prevention of catheter-associated urinary tract infection (CAUTI). I do laboratory-based, translational microbiology research as well as health services research. My laboratory studies bacterial interference, or the use of benign bacterial to prevent symptomatic infection with pathogens. In vitro we are studying methods to enhance biofilm formation on urinary catheters by benign E. coli. One approach has been to modify the catheter surface with receptors for the E. coli fimbriae. Another approach is to add a bacteriophage suspension to the media that attacks uropathogens, such as Pseudomonas, but that does not affect the E. coli. In clinical trials we utilize urinary catheters coated with a biofilm of benign E. coli to achieve bladder colonization and protection from catheter-associated UTI. These translational studies are performed at the Michael E. DeBakey Veterans Affairs Medical Center.
I also have several active health services research projects which are performed primarily at the VA Health Services Research Center of Excellence. We are studying an approach to decrease over diagnosis of CAUTI by implementing guidelines concerning non-treatment of asymptomatic bacteriuria (ABU). Our intervention is based upon audit-feedback. Another project involves using natural language processing to review medical records for urinary catheter use. We also use VA administrative data bases to address explore factors behind quality of care issues, such as discharge delays on holidays, or determining the appropriate denominator for healthcare-acquired infections.
Department of Medicine
Section of Infectious Diseases
Baylor College of Medicine
One Baylor Plaza, MS BCM286
Houston, TX, 77030, U.S.A.
A.B., Princeton University, 1991
M.D., University of Virginia School of Medicine, 1995
Ph.D., Baylor Graduate School of Biomedical Sciences, 2007