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Molecular Virology and Microbiology

Houston, Texas

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Department of Molecular Virology and Microbiology
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Wendy A. Keitel, M.D.

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 Wendy A. Keitel, M.D.

Associate Professor
Department of Molecular Virology & Microbiology

Research Interests

Vaccine Development and Evaluation

Infectious diseases remain major causes of morbidity and mortality in human populations. Prevention of infection or illness by means of immunization is considered one of the greatest public health accomplishments of all times. We are interested in the development and evaluation of a number of vaccines, with a particular emphasis on prevention of respiratory infections and other emerging infectious diseases. Our group is involved in both the preclinical and clinical stages of vaccine development, including phase I to phase IV clinical trials. Recent research activities have focused on the development of live attenuated and improved inactivated influenza virus vaccines, including 2009 H1N1 vaccines and other candidate vaccines for control of pandemic influenza (H5, H7, and H9). We are also exploring immunization of pregnant women to protect both the mother and her baby against influenza and pertussis. Major goals for improved vaccines include enhancement of mucosal and cell-mediated immune responses. Several approaches are being explored to achieve these goals, including topical administration of antigens (oral or intranasal), increasing the dose of antigen, combined topical and parenteral immunization, and evaluation of candidate adjuvants. Other activities include evaluation of vaccines for prevention of smallpox, cytomegalovirus and rotavirus infections; and development of a human challenge model for Norovirus infection which can be used to evaluate vaccines and other control measures

Contact Information

Department of Molecular Virology & Microbiology
Baylor College of Medicine
One Baylor Plaza, MS BCM280
Houston, TX, 77030, U.S.A.

713-798-5250
wkeitel@bcm.edu

Education

M.D. - Duke University
Residencies -
Internal Medicine Infectious Diseases, Duke University
Baylor College of Medicine

Recent Publications (PubMed)

Oxman M, Levine M, Johnson G, et al. Prevention of herpes zoster and postherpetic neuralgia in older adults with a live attenuated varicella-zoster virus vaccine: Results of the Department of Veterans’ Affairs Cooperative Study #403-the Shingles Prevention Study. NEJM 2005; 352:2271.

Ward J, Cherry J, Chang S-J, Partridge S, Lee H, Treanor J, Greenberg D, Keitel W, Barenkamp S, Bernstein D, Edelman R, Edwards K, Klein D and the APERT Study Group. Efficacy of an Acellular Pertussis Vaccine Among Adolescents and Adults in a Prospective National Randomized Acellular Pertussis Vaccine Trial (APERT). NEJM 2005; 353:1.

Keitel WA, Atmar RL, Cate TR, Petersen NJ, Greenberg SB, Ruben F, Couch RB. Safety of high doses of influenza vaccine and effect on antibody responses in elderly persons. Arch Intern Med 2006; 166: 1121-7.

Keitel W, CampbellJ, TreanorJ, WalterE, PatelS, HeF, and NoahD. Safety and Immunogenicity of an Inactivated Influenza A/H5N1 Vaccine Given Without or With Aluminum Hydroxide to Healthy Adults: Results of a Phase I-II Randomized Clinical Trial. J Infect Dis 2008; 198:1-8.

Keitel WA, TreanorJJ, El-SahlyHM, Evans TG, Kopper S, Whitlow V, Selinsky C, Kaslow D, Rolland A, SmithLR and Lalor PA. Evaluation of a plasmid DNA-based anthrax vaccine in rabbits, nonhuman primates and healthy adults. Human Vaccines 2009; 5: 1-9.

El Sahly HM, Atmar RL, Patel SM, Wells JM, Cate T, Ho M, Guo K, Pasetti MF, Lewis DE, Sztein MB, Keitel WA. Safety, reactogenicity and immunogenicity of Francisella tularensis live vaccine strain in humans. Vaccine 2009;27:4905-11.

Keitel W, GrothN, LattanziM, PrausM, HilbertA, Borkowski A, TsaiT. Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: safety and immunogenicity of a phase 1/2 clinical trial. Vaccine 2010; 28:840-8.