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Molecular Virology & Microbiology - Alkek Center for Metagenomics and Microbiome Research

Houston, Texas

A BCM research lab.
Department of Molecular Virology and Microbiology
not shown on screen

Project: A Preliminary Comparison of the Distal Gut Microbiome from HIV Infected Before and After HAART

University Association: Baylor College of Medicine
Collaborator Name: Lara Bull-Otterson Ph.D.

Within the last decade the requisite role of the GI tract in HIV infection and pathogenesis has become increasingly evident. HIV viral replication is believed to play a fundamental role in perpetuating microbial translocation into the systemic circulation, suggesting that the microbiome may have significant impact on disease progression and long-term outcomes in HIV infected persons. To examine the relationship between HIV infection and the distal colon’s microbiome, we evaluated the difference in microbial community structure and diversity in treatment-naïve HIV infected patients (CD4 cell count <250 cells/mm3) before and after Highly Active Antiretroviral Therapy (HAART) and matched HIV negative controls.