Project: A Preliminary Comparison of the Distal Gut Microbiome from HIV Infected Before and After HAART
University Association: Baylor College of Medicine
Collaborator Name: Lara Bull-Otterson Ph.D.
Within the last decade the requisite role of the GI tract in HIV infection and pathogenesis has become increasingly evident. HIV viral replication is believed to play a fundamental role in perpetuating microbial translocation into the systemic circulation, suggesting that the microbiome may have significant impact on disease progression and long-term outcomes in HIV infected persons. To examine the relationship between HIV infection and the distal colon’s microbiome, we evaluated the difference in microbial community structure and diversity in treatment-naïve HIV infected patients (CD4 cell count <250 cells/mm3) before and after Highly Active Antiretroviral Therapy (HAART) and matched HIV negative controls.