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Physio - Zhang Lab

Houston, Texas

A BCM research lab.
Pumin Zhang Lab
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  1. Zhang W, Peng G, Lin SY, Zhang P. DNA Damage Response Is Suppressed by the High Cyclin-dependent Kinase 1 Activity in Mitotic Mammalian Cells. J Biol Chem. 2011 Oct 14;286(41):35899-905.
  2. Fang X, Zhang P. (Epub ahead of print). Aneuploidy and Tumorigenesis. Semin Cell Dev Biol. 2011 Mar 7.
  3. Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen JM, Zhang P. (2011). Early-onset Aging and Defective DNA Damage Response in Cdc14b-deficient Mice. Mol Cell Biol. 2011 Apr;31(7):1470-7.
  4. Li, M. Fang, X., Baker, D.J., Guo, L., Gao, X., Wei, Z., Han, S., van Derusen, J., and Zhang, P. (2010). The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis in mice. Proc Natl Acad Sci USA 107: 14188-93.
  5. Gao, X., Shin, Y. H., Li, M., Wang, F., Tong, Q., and Zhang, P. (2010). The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS ONE 5: e14005.
  6. Huang X, Andreu-Vieyra CV, Wang, M., Cooney, A., Matzuk MM, and Zhang, P. (2009) Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation. Mol. Cell Biol. 29, 1498­1505 .
  7. Li, M., Fang, X., Wei, Z., York, J. P. and Zhang, P. (2009). Loss of Mad2-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J. Cell Biol. 185, 983-994.
  8. Li, M., Shin, Y. H., Lin, F., Klann, E. and Zhang, P. (2008). The adaptor protein of the anaphase promoting complex Cdh1 plays an essential role in maintaining replicative life span and in learning and memory. Nat Cell Biol. 10, 1083-3089.
  9. Huang, X., Hatcher, R., and Zhang, P. (2008). Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol. 6, e15
  10. Jia, J., Li, M., Zhang, L., York, J. P., and Zhang, P. (2007) The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression. Mol. Cell Biol. 27, 7236-47.
  11. Li, M., York, J. P., and Zhang, P. (2007). Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol. Cell Biol. 27, 3481-8.
  12. Georgia, S., Li, M., Zhang, P.*, and Bhushan, A*. (2006). p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev. Biol. 298, 22-31. (* corresponding authors).
  13. Peng, X., York, J.P., and Zhang, P. (2006). A transgenic approach for RNA interference-based genetic screening in mice. Proc Natl Acad Sci USA 103, 2252-2256.
  14. Huang, X., Tran, T., Zhang, L., Hatcher, R., Zhang, P. (2005). DNA damage induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci USA. 102:1065-70.
  15. Huang, X., Hatcher, R., York, J.P., and Zhang, P. (2005). Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell 16: 4725-32
  16. Zhang, P., Liu, M., and Elledge, S. (2002). Towards genetic genome projects: genomic library screening and gene targeting vector construction in a single step. Nature Genet. 30, 31-39.
  17. Mei, J., Huang, X. and Zhang, P. (2001). Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr. Biol. 11, 1197-1201.