skip to content »

Physio - Wehrens Lab

Houston, Texas

BCM faculty, staff and trainees are the heart of the organization.
Xander H.T. Wehrens Lab
not shown on screen

Publications

Recent publications

  1. Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XH, Nattel S, Dobrev D. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14;129(2):145-56. doi: 10.1161/CIRCULATIONAHA.113.006641. Epub 2013 Nov 18. PubMed PMID: 24249718.

  2. Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XH. Ryanodine-Receptor Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model. Circulation. 2014 Jan 7. [Epub ahead of print] PubMed PMID: 24398018.
  3. Ho HT, Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Györke S. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 1;101(1):165-74. doi: 10.1093/cvr/cvt233. Epub 2013 Oct 8. PubMed PMID: 24104877; PubMed Central PMCID: PMC3868350.
  4. Ather S, Respress JL, Li N, Wehrens XH. Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta. 2013 Dec;1832(12):2425-31. doi: 10.1016/j.bbadis.2013.06.008. Epub 2013 Jun 14. PubMed PMID: 23770282; PubMed Central PMCID: PMC3800473.
  5. Beavers DL, Wang W, Ather S, Voigt N, Garbino A, Dixit SS, Landstrom AP, Li N, Wang Q, Olivotto I, Dobrev D, Ackerman MJ, Wehrens XH. Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. J Am Coll Cardiol. 2013 Nov 19;62(21):2010-9. doi: 10.1016/j.jacc.2013.06.052. Epub 2013 Aug 21. PubMed PMID: 23973696; PubMed Central PMCID: PMC3830688.
  6. Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15;128(16):1748-57. doi: 10.1161/CIRCULATIONAHA.113.003313. Epub 2013 Sep 12. PubMed PMID: 24030498; PubMed Central PMCID: PMC3876034
  7. Chen B, Guo A, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS. Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res. 2013 Oct 1;100(1):54-62. doi: 10.1093/cvr/cvt180. Epub 2013 Jul 16. PubMed PMID: 23860812; PubMed Central PMCID: PMC3778961.
  8. Reynolds JO, Chiang DY, Wang W, Beavers DL, Dixit SS, Skapura DG, Landstrom AP, Song LS, Ackerman MJ, Wehrens XH. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 1;100(1):44-53. doi: 10.1093/cvr/cvt133. Epub 2013 May 27. PubMed PMID: 23715556; PubMed Central PMCID: PMC3778955.
  9. Ather S, Bavishi C, McCauley MD, Dhaliwal A, Deswal A, Johnson S, Chan W, Aguilar D, Pritchett AM, Ramasubbu K, Wehrens XH, Bozkurt B. Worsening renal function is not associated with response to treatment in acute heart failure. Int J Cardiol. 2013 Sep 1;167(5):1912-7. doi: 10.1016/j.ijcard.2012.05.004. Epub 2012 May 25. PubMed PMID: 22633437.
  10. Wehrens XH, Chiang DY, Li N. Chronic exercise: a contributing factor to atrial fibrillation? J Am Coll Cardiol. 2013 Jul 2;62(1):78-80. doi: 10.1016/j.jacc.2013.02.070. Epub 2013 Apr 9. PubMed PMID: 23583764; PubMed Central PMCID: PMC3702168.
  11. Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20;166(2):366-74. doi: 10.1016/j.ijcard.2011.10.057. Epub 2011 Nov 16. PubMed PMID: 22093963.
  12. Wu SP, Cheng CM, Lanz RB, Wang T, Respress JL, Ather S, Chen W, Tsai SJ, Wehrens XH, Tsai MJ, Tsai SY. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013 May 28;25(4):417-26. doi: 10.1016/j.devcel.2013.04.017. PubMed PMID: 23725765; PubMed Central PMCID: PMC3687546.
  13. Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr;10(4):592-9. doi: 10.1016/j.hrthm.2012.12.016. Epub 2012 Dec 12. PubMed PMID: 23246599; PubMed Central PMCID: PMC3605194.
  14. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26;127(8):913-22. doi: 10.1161/CIRCULATIONAHA.12.148619. Epub 2013 Jan 30. PubMed PMID: 23363625; PubMed Central PMCID: PMC3690126.
  15. Heijman J, Wehrens XH, Dobrev D. Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry? Acta Physiol (Oxf). 2013 Feb;207(2):208-11. doi: 10.1111/apha.12038. PubMed PMID: 23157571.
  16. Li N, Wehrens XH. Extinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm. 2013 Jan;10(1):108-9. doi: 10.1016/j.hrthm.2012.10.018. Epub 2012 Oct 17. PubMed PMID: 23085093.
  17. Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013 Sep 27;8(9):e75882. doi: 10.1371/journal.pone.0075882. eCollection 2013. PubMed PMID: 24086656; PubMed Central PMCID: PMC3785418.
  18. Dixit SS, Wang T, Manzano EJ, Yoo S, Lee J, Chiang DY, Ryan N, Respress JL, Yechoor VK, Wehrens XH. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013;8(3):e58655. doi: 10.1371/journal.pone.0058655. Epub 2013 Mar 13. PubMed PMID: 23516528; PubMed Central PMCID: PMC3596297.
  19. DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec;9(12):2034-41. doi: 10.1016/j.hrthm.2012.08.026. Epub 2012 Aug 28. PubMed PMID: 23059182; PubMed Central PMCID: PMC3630478.
  20. Wu Y, Luczak ED, Lee EJ, Hidalgo C, Yang J, Gao Z, Li J, Wehrens XH, Granzier H, Anderson ME. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep;53(3):429-36. doi: 10.1016/j.yjmcc.2012.06.019. Epub 2012 Jul 11. PubMed PMID: 22796260.
  21. Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ Jr, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 5;125(22):2751-61. doi: 10.1161/CIRCULATIONAHA.111.044354. Epub 2012 May 8. PubMed PMID: 22570371; PubMed Central PMCID: PMC3503489.
  22. Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Skårdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25;110(11):1474-83. doi: 10.1161/CIRCRESAHA.112.268094. Epub 2012 Apr 17. PubMed PMID: 22511749; PubMed Central PMCID: PMC3371642.
  23. Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 1;125(17):2059-70. doi: 10.1161/CIRCULATIONAHA.111.067306. Epub 2012 Mar 28. PubMed PMID: 22456474.
  24. Wang T, Wehrens XH. Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform. Heart Rhythm. 2012 Apr;9(4):598-9. doi: 10.1016/j.hrthm.2011.11.049. Epub 2011 Nov 30. PubMed PMID: 22138134.
  25. Ather S, Chan W, Bozkurt B, Aguilar D, Ramasubbu K, Zachariah AA, Wehrens XH, Deswal A. Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol. 2012 Mar 13;59(11):998-1005. doi: 10.1016/j.jacc.2011.11.040. PubMed PMID: 22402071.
  26. Jayasinghe ID, Baddeley D, Kong CH, Wehrens XH, Cannell MB, Soeller C. Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys J. 2012 Mar 7;102(5):L19-21. doi: 10.1016/j.bpj.2012.01.034. Epub 2012 Mar 6. PubMed PMID: 22404946; PubMed Central PMCID: PMC3296050.
  27. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22;483(7387):96-9. doi: 10.1038/nature10852. PubMed PMID: 22367544; PubMed Central PMCID: PMC3297978.
  28. Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 3;110(3):465-70. doi: 10.1161/CIRCRESAHA.111.253229. Epub 2011 Dec 8. PubMed PMID: 22158709; PubMed Central PMCID: PMC3272138.
  29. Liu D, Huang L, Wang Y, Wang W, Wehrens XH, Belousova T, Abdelrahim M, DiMattia G, Sheikh-Hamad D. Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS One. 2012;7(5):e36994. doi: 10.1371/journal.pone.0036994. Epub 2012 May 31. Erratum in: PLoS One. 2012;7(9). doi:10.1371/annotation/52d155b7-66af-425f-9a6a-2d853d5fd95d. PubMed PMID: 22693564; PubMed Central PMCID: PMC3365029.
  30. Jeyaraj D, Halder SM, Wan X, McCauley MD, Lu Y, Eapen B, Ripperger JA, Albrecht U, Sharma N, Cutler M, Gulick J, Sanbe A, Robbins J, Wehrens XH, Rosenbaum DS, Jain MK. Circadian Clock regulates cardiac repolarization and susceptibility to arrhythmias. Nature. 2012 Feb 22;483(7387):96-9. doi: 10.1038/nature10852.
  31. Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar;4(2):214-23. Epub 2011 Jan 7.
  32. McCauley MD, Wehrens XH. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun;32(6):749-57.
  33. Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar 1;4(2):214-23.
  34. Dobrev D, Voigt N, Wehrens XH. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2010 Nov 3.
  35. Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2010 Sep 29.
  36. Garbino A, Wehrens XH. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin. 2010 Sep;31(9):1019-21.
  37. Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan;20(1):30-4.
  38. McCauley MD, Wehrens XH. Ambulatory ECG recording in mice. J Vis Exp. 2010 May 27;(39). pii: 1739.
  39. Respress JL, Wehrens XH. Transthoracic echocardiography in mice. J Vis Exp. 2010 May 28;(39). pii: 1738.
  40. Li N, Wehrens XH. Programmed electrical stimulation in mice. J Vis Exp. 2010 May 26;(39). pii: 1730.
  41. Ather S, Peterson LE, Divakaran VG, Deswal A, Ramasubbu K, Giorgberidze I, Blaustein A, Wehrens XH, Mann DL, Bozkurt B. Digoxin treatment in heart failure - Unveiling risk by cluster analysis of DIG data. Int J Cardiol. 2010 May 13.
  42. Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9753-8.
  43. deAlmeida AC, van Oort RJ, Wehrens XH. Transverse aortic constriction in mice. J Vis Exp. 2010 Apr 21;(38). pii: 1729.
  44. van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ,Wehrens XH. Accelerated Development of Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model. Hypertension. 2010 Feb 15.
  45. Wang W, Wehrens XH. Stress synchronizes calcium release and promotes SR calcium leak. J Physiol. 2010 Feb 1;588(Pt 3):391-2.
  46. Koshelev M, Sarma S, Price RE, Wehrens XH, Cooper TA. Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Jan 8.
  47. Mathur N, Sood S, Wang S, van Oort RJ, Sarma S, Li N, Skapura DG, Bayle JH, Valderrábano M, Wehrens XH. Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol. 2009 Dec;2(6):677-8.
  48. McCauley MD, Wehrens XH. Animal models of arrhythmogenic cardiomyopathy. Dis Model Mech. 2009 Nov-Dec;2(11-12):563-70.
  49. Garbino A, van Oort RJ, Dixit SS, Landstrom AP, Ackerman MJ, Wehrens XH. Molecular evolution of the junctophilin gene family. Physiol Genomics. 2009; 37(3): 175-86.
  50. Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009; 106(14): 5972-7.
  51. Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol. 2009; 106(4): 1280-92.
  52. van Oort RJ, Altamirano J, Lederer WJ, Wehrens XH. Alternative splicing: a key mechanism for ankyrin-B functional diversity? J Mol Cell Cardiol. 2008; 45(6): 709-11.
  53. Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L. 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet. 2009; 46(3): 168-75.
  54. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH.Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008; 5(7): 1047-54.
  55. Bourajjaj M, Armand AS, da Costa Martins PA, Weijts B, van der Nagel R, Heeneman S,Wehrens XH, De Windt LJ. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem. 2008; 283(32): 22295-303.

Previous Key Publications

  1. Li N, Wang T, Wang W, Culter MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XHT. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knock-out mice. Circ Res 2012; 110(3): 465-70.
  2. van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.Circulation. 2011 Mar 8;123(9):979-88
  3. van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 8;123(9):979-88.
  4. van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure. Circulation. 2010 Dec 21;122(25):2669-79.
  5. Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13165-70.
  6. Wang GS, Kuyumcu-Martinez MN, Mathur N, Wehrens XHT, Cooper TA. PKC inhibition ameliorates the cardiac phenotype of a mouse model for myotonic dystrophy type 1. J Clin Invest 2009; 119(12): 3797-806.
  7. Wehrens XH, Lehnart SE, Reiken SR, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression. Proc Natl Acad Sci U.S.A. 2006; 103: 511-18.
  8. Lehnart SE*, Wehrens XH*, Reiken SR, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SLC, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine receptor complex promotes heart failure and arrhythmias. Cell 2005; 123: 25-35 (* contributed equally)
  9. Wehrens XH, Lehnart SE, Reiken SR, Van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR. Enhancing calstabin binding to ryanodine receptors improves both cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U.S.A. 2005; 102: 9607-9612.
  10. Vest JA*, Wehrens XH*, Reiken SR*, Lehnart SE, Chandra P, Danilo P, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation 2005; 111: 2025-2032. (* contributed equally).
  11. Wehrens XH. Structural determinants of potassium channel blockade and drug-induced arrhythmias. In: Basic and treatment of cardiac arrhythmias, Chapter 6. Eds. R.S. Kass and C.E. Clancy. Handbook of Experimental Pharmacology (Ed. K. Starke). 2005;171:123-157.
  12. Wehrens XH, Lehnart SE, Marks AR. Calcium release and cardiac failure. Annu Rev Physiol, 2005; 67: 69-98.
  13. Wehrens XH, Lehnart SE, Reiken SR, Marks AR. CaMKII phosphorylation regulates the cardiac ryanodine receptor. Circ Res 2004; 94: e61-e71.
  14. Wehrens XH, Lehnart SE, Reiken SR, Vest J, Cervantes D, Coromilas J, Deng SX, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science 2004; 304: 292-296.
  15. Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalising calcium cycling. Nat Rev Drug Disc 2004; 3(7): 565-73.
  16. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D’Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 2003; 113: 829-840.
  17. Wehrens XH, Abriel H, Cabo C, Benhorin J, Kass RS. Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na + channel a subunit: a computational analysis. Circulation 2000; 102: 584-90.