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Physio - Wehrens Lab

Houston, Texas

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Xander H.T. Wehrens Lab
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Mark McCauley, M.D.

Mark McCauley, M.D.Education

B.S., Biochemistry and Molecular Biology, Trinity University, 2002
Magna Cum Laude, Phi Beta Kappa

M.D., Baylor College of Medicine, 2006
President of the Student Internal Medicine Society

Ph.D., Baylor College of Medicine, 2011
MeRIT Scholar, Recipient of T32 and NIH Loan Repayment Awards

Internal Medicine Residency, Baylor College of Medicine, 2011
Diplomate of the American Board of Internal Medicine

Cardiology Fellow, Texas Heart Institute / Baylor College of Medicine, present

Research Interest/Project


Dr. McCauley is interested in the molecular mechanisms underlying cardiac arrhythmias and sudden cardiac death. He is currently studying the cardiac ryanodine receptor (RyR2) and how errors in diastolic Ca2+ leak predispose mouse models to cardiac arrhythmias.

Publications


McCauley MD, Wehrens XH. Ryanodine Receptor Phosphorylation, Calcium/Calmodulin-Dependent Protein Kinase II, and Life-Threatening Ventricular Arrhythmias. Trends Cardiovasc Med. 2012, in press.

Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22;483(7387):96-9. doi: 10.1038/nature10852.

McCauley MD, Wang T, Mike E, Herrera J, Beavers DL, Huang TW, Ward CS, Skinner S, Percy AK, Glaze DG, Wehrens XH, Neul JL. Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med. 2011 Dec 14;3(113):113ra125.

McCauley MD, Wehrens XH. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun;32(6):749-57.

van Oort RJ*, McCauley MD*, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21;122(25):2669-79. Epub 2010 Nov 15.

McCauley MD, Wehrens XH. Ambulatory ECG recording in mice. J Vis Exp. 2010 May 27;(39).

McCauley MD, Wehrens XH. Animal models of arrhythmogenic cardiomyopathy. Dis Model Mech. 2009 Nov-Dec;2(11-12):563-70.