Ergun Sahin, M.D., Ph.D.
Departments of Molecular Physiology and Biophysics, Huffington Center On Aging
M.D. Free University Berlin, Germany
Ph.D. Free University Berlin, Germany
Postdoctoral: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
Dr. Sahin studies the role of telomerase and telomeres in cancer and aging. Telomeres, repetitive G-riche sequences at the end of chromosomes, become shorter during aging as most human cells do not have sufficient activity of the enzyme telomerase that that maintains telomeres. Shortening of telomeres causes cells to undergo aging (senescence), which is prevented by the re-expression of telomerase. Dr. Sahin’s laboratory is studying the mechanisms underlying telomere shortening driven senescence with particular interest how compromised telomeres intersect with metabolic pathways. Using a combination of telomerase mouse models and in–vitro based human and mouse cell systems the role of telomeres and telomerase reactivation (a hallmark of most cancers) for the aging process and cancer formation is dissected.