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Physio - Lagor Lab

Houston, Texas

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Physio - Lagor Lab
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Lagor - Publications

Kassim S.H., Li H., Bell P., Somathanan S., Lagor W.R., Jacobs F., Billheimer J.T., Wilson J.M., Rader D.J. AAV8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial Hypercholesterolemia. Hum Gene Ther. 2012 Sept 17.

Lagor W.R., Fields D.W., Khetarpal S.A., Kumaravel A., Lin W., Weintraub N., Wu K., Hamm-Alvarez S.F., Drazul-Schrader D., de la Llera-Moya M., Rothblat G.H., and Rader D.J. The Effects of Apolipoprotein F Deficiency on High Density Lipoprotein Cholesterol Metabolism in Mice. PLoS One. 2012;7(2):e31616. Epub 2012 Feb 20. PMID: 22363685

Boone L.R., Lagor W.R., de la Llera Moya M., Niesen M.I., Rothblat G.H., Ness G.C. Thyroid Hormone Enhances the Ability of Serum to Accept Cellular Cholesterol via the ABCA1 Transporter.
Atherosclerosis May 6, 2011. PMID: 21605865

Nijstad N., de Boer J.F., Lagor W.R., Toelle M., Usher D. Annema W., Van der Giet M., Rader, D.J., Tietge U.J.F. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Biochim Biophys Acta. 2011 Feb 3. PMID: 21296681

Lagor W.R. and Rader D.J. Phospholipidation of HDL: How much is too much? Clin Chem. 2011 Jan;57(1):4-6. PMID: 21078838

Burkhardt Ra., Toh S. a (a co-first authors), Lagor W. R., Birkeland A., Levin M., Li X., Robblee M., Fedorov V., Wang J., Ripatti S., Tikkanen E., Orho-Melander M., Havulinna A.S., Silander K., Melander O., Salomaa V., Yamamoto M., Akira S., Hegele R.A., Kathiresan S., Breslow J.L., Daniel J. Rader. Trib1, a novel lipid and MI associated gene, regulates hepatic lipogenesis and VLDL production. J Clin Invest. 2010 Dec 1;120(12):4410-4. PMID: 21084752

Brown R.J., Lagor W.R., Sankaranaravanan S., Yasuda T., Quertermous T., Rothblat G.H., Rader D.J. The impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high density lipoproteins and apoB-containing lipoproteins. Circ Res. 2010 Aug 6;107(3):357-64. PMID: 20558822

Lagor W.R., Millar J.S. Overview of the LDL receptor: relevance to cholesterol metabolism and future approaches for the treatment of coronary heart disease. (Dec. 15, 2009) Journal of Receptor, Channel and Ligand Research 2010: (3); 1-10.

Davidson W.S., Silva R.A., Chantepie S., Lagor W.R., Chapman M.J., Kontush A. Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters. Relevance to Antioxidative Function. (2009) ATVB March 26, 2009. PMID:19325143

Niesen, M.I., Osborne A.R., Lagor, W.R., Zhang, H., Kazemfar, K., Ness, G.C., and Blanck B., Technological Advances in the study of HLA-DRA Promoter Regulation: Extending the Functions of CIITA, Oct-1, Rb, and RFX. (2009) Acta Biochim Biophys Sin 41: 198-205. PMID: 19280058

Lagor W.R., Brown R.J., Toh S, Millar J.S., Fuki I.V., de la Llera-Moya M., Yuen T., Rothblat G., Billheimer J.T., and Rader D.J. Overexpression of Apolipoprotein F reduces HDL cholesterol levels in vivo. (2009) ATVB. Jan 29(1):40-6. PMID: 19008531

Lagor W.R., Heller R, de Groh E.D., Ness G.C. Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation. (2007) Exp. Biol. Med. (Maywood). Mar 232(3):353-61. PMID: 17327468

Lagor W.R., de Groh E.D., Ness G.C. (2005) Diabetes Alters the Occupancy of the Hepatic 3-Hydroxy-3-Methylglutaryl-CoA Reductase Promoter. J. Biol. Chem. Nov. 4, 280 (44): 36601-36608. PMID: 16127173

Osborne A.R., Pollock V.V., Lagor W.R., Ness G.C. Identification of Insulin-responsive Regions in the HMG-CoA Reductase Promoter. (2004) Biochem. Biophys. Res. Commun. Jun. 11; 318 (4): 814-818. PMID: 15147943

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