Cardiovascular Sciences Graduate Students
- Viktor Feketa Homeothermic, or warm-blooded, animals, including humans, are able to maintain their core temperature within a narrow range, even when exposed to cold environment. They are able to sense cold by specialized cold-sensitive receptors, and activate cold-defense response which in mice mainly includes peripheral vasoconstriction, shivering thermogenesis and increase in brown adipose tissue metabolism. I am studying the role of recently discovered molecular sensor of cold, TRPM8 ion channel, in activation of thermoregulatory effector pathways and ability of mice to regulate core temperature under cold stress.
- Lele Li I am interested in signaling pathway of necrosis. Accumulating evidences imply necrosis can be a regulated event. Currently, my work is screening proteins functioning in necrosis process and exploring possible signaling pathway and molecular mechanism of necrosis.