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Department of Molecular Physiology and Biophysics

Houston, Texas

A BCM research lab.
Molecular Physiology and Biophysics
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Molecular Physiology and Biophysics Faculty

Primary Appointments

Joseph H. Bayle, Ph.D.
Assistant Professor
Further develop and apply drug inducible protein allele technology to study Pax6 and other factors that have multiple roles spatially and/or temporally during development.

Christine Beeton, Ph.D.
Assistant Professor
Research in my laboratory focuses on ion channels in cells of the innate immune system such as natural killer cells. We study the role of these channels on the function of the immune system in health and disease using a combination of cell biology, electrophysiology and animal models.

Mary Dickinson, Ph.D.
My laboratory uses a multi-disciplinary approach to study the role of fluid-derived mechanical forces in vascular remodeling and heart morphogenesis in early mouse and zebrafish embryos. Using time-lapse, rapid confocal and multispectral imaging of florescent protein reporters we are characterizing changes in endothelial cells in response to mechanical stress in living organisms.

Dimitra Georgiou, Ph.D.
Assistant Professor
Role of calcium ion and calcium handling proteins in the regulation of skeletal muscle metabolism function and performance, from animal models to signaling pathways.

Susan L. Hamilton, Ph.D.
Chair and Professor
Skeletal Muscle Excitation-Contraction coupling, ryanodine receptors L-type Ca2+ Channels and diseases of skeletal muscle.

Frank T. Horrigan, Ph.D.
Associate Professor
Molecular and biophysical mechanisms of ion channel gating. Allosteric regulation of BK potassium channel function.

William R. Lagor, Ph.D.
Assistant Professor
My research is focused on the regulation of lipid and lipoprotein metabolism.

Irina Larina, Ph.D.
Assistant Professor
We are working on development and application of highly innovative methods for live dynamic imaging and analysis of mammalian embryonic development.

Na Li, Ph.D.
Assistant Professor
We are focused on the elucidation of novel molecular and cellular mechanisms underlying the development of atrial fibrillation (AF), which is the most common cardiac arrhythmi.

James F. Martin, M.D., Ph.D.
We are interested in understanding how developmental pathways are connected to adult tissue regeneration. We are investigating the Hippo, Wnt, and Bmp-signaling pathways for developmental and regenerative capabilities

Joel Neilson, Ph.D.
Assistant Professor
Post-transcriptional gene regulation in mammalian development and disease by microRNAs and RNA-binding proteins.

Robia G. Pautler, Ph.D.
Associate Professor
A multi-disciplinary approach combining MRI with molecular biology, genetics, computational biology and neuroscience, focused upon understanding the processes governing neurodegeneration and learning and memory.

Steen Pedersen, Ph.D.
Associate Professor
Allosteric mechanisms of ligand-gated ion channels; functional aspects of gating, ion selectivity, and ligand binding are determined with biophysical methods.

Ross Poché, Ph.D.
Assistant Professor
Transcriptional regulation of neural progenitor proliferation and differentiation, ocular vessel remodeling and regression, live retinal neuron and eye vascular microscopy, regenerative medicine.

George G. Rodney, Ph.D.
Assistant Professor
Real-time imaging of sub-cellular reactive oxygen species, Ca2+ signaling, and excitation-contraction coupling in skeletal muscle under physiological and pathophysiological conditions.

Ergun Sahin, M.D., Ph.D.
Assistant Professor
A member of the Huffington Center on Aging
Studing the role of telomerase and telomeres in cancer and aging.

Lubov Timchenko, Ph.D.
My laboratory is investigating molecular mechanisms of two multisystem, neuro-muscular diseases, Myotonic Dystrophies 1 and 2 (DM1 and DM2). These diseases are caused by expansion of polymorphic un-translated CUG RNA repeats (DM1) and CCUG RNA repeats (DM2). Our work is focused on the molecular mechanisms by which the mutant CUG and CCUG RNAs result in DM1 and DM2 pathologies.

Xander Wehrens, M.D., Ph.D.
Research in our lab focuses on the regulation of cardiac ion channels in normal and diseased hearts. In particular, we study the regulation of the intracellular calcium release channel/ ryanodine receptors, and how abnormal calcium release may contribute to the development of cardiac arrhythmias, hypertrophy and heart failure.

Pumin Zhang, Ph.D.
Research in this laboratory focus on the control of cell division cycles in development and disease. We are particularly interested in how the cell cycle checkpoints are activated in response to internal and external stimuli and how these checkpoints prevent cell cycle progression.

Secondary Appointments

Kjersti M. Aagaard-Tillery, M.D., Ph.D.
Assistant Professor, Obstetrics & Gynecology

Christie M. Ballantyne, M.D.
Professor of Medicine, Chief, Cardiovascular Research Section

John W. Belmont, M.D., Ph.D.
Professor, Department of Molecular and Human Genetics

Penelope E. Bonnen, Ph.D.
Assistant Professor, Department of Molecular and Human Genetics

Aladin M. Boriek, Ph.D.
Associate Professor, Department of Medicine

Biykem Bozkurt, M.D.
Professor of Medicine
Chief of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center

Malcolm K. Brenner, M.D., Ph.D.
Professor, Director - Center for Cell and Gene

Robert M. Bryan, Jr., Ph.D.
Professor, Department of Anesthesiology

William E. Brownell, Ph.D.
Otolaryngology-Head & Neck Surgery

Wah Chiu, Ph.D.
Distinguished Service Professor, Department of Biochemistry

Thomas A. Cooper, M.D.
Professor, Pathology

William J. Craigen, M.D., Ph.D.
Professor, Department of Molecular and Human Genetics

Miguel A. Cruz, Ph.D.
Associate Professor, Interim Division Chief of Thrombosis Research, Medicine

N. Tony Eissa, M.D.
Professor of Medicine

Mark L. Entman, M.D.
Professor, Department of Medicine

Xin-Hua Feng, Ph.D.
Professor, Surgery

Marta L. Fiorotto, Ph.D.
Associate Professor, Department of Pediatrics-Nutrition

Yadollah Harati, M.D.
Professor of Neurology

Craig J. Hartley, Ph.D.
Professor, Medicine - Cardiovascular Sciences

Sandra B. Haudek, Ph.D.
Assistant Professor, Medicine - Cardiovascular Sciences

Amit Joshi, Ph.D.
Assistant Professor, Radiology

Scott A. LeMaire, M.D.
Professor, Surgery

Sean P. Marrelli, Ph.D.
Assistant Professor, Department of Anesthesiology

Lloyd H. Michael, Ph.D.
Professor, Sr Associate Dean, Sr VP & Dean of Medical Education

Jeffrey L. Neul, M.D., Ph.D.
Assistant Professor, Pediatrics - Neurology, Assistant Medical Director - Blue Bird Circle Rett Center

Paul Pfaffinger, Ph.D.
Associate Professor, Department of Neuroscience

Cecile L. Phan, M.D.
Assistant Professor of Neurology

Florante A. Quiocho, Ph.D.
Professor, Department of Biochemistry and Molecular Biology

Arun S. Rajan, M.D.
Associate Professor of Medicine

Peter Saggau, Ph.D.
Professor, Neuroscience

Daryl Scott, M.D., Ph.D.
Assistant Professor, Department of Molecular and Human Genetics

Richard N. Sifers, Ph.D.
Associate Professor, Pathology

George E. Taffet, M.D.
Associate Professor, Medicine-Geriatrics

Addison Taylor, M.D., Ph.D.

Professor of Medicine

Qiang Tong, Ph.D.
Assistant Professor, Pediatrics-Nutrition

Vinod K. Vijayan, Ph.D.
Assistant Professor, Medicine - Thrombosis

Samuel M. Wu, Ph.D.
Professor, Department of Ophthalmology

Adjunct Appointments

K. Jane Grande-Allen, Ph.D.
Adjunct Associate Professor of Bioengineering, Rice University, Houston, TX

Jeffrey Jacot, Ph.D.,
Adjunct Assistant Professor, Bioengineering, Rice University

Kirill Larin, Ph.D.
Assistant Professor of Biomedical Engineering and Mechanical Engineering, University of Houston, Houston, TX

Ali J. Marian, M.D.
Associate Professor, Medicine - Cardiology Texas Heart Institute, St. Lukes, Houston, TX

Henry Pownall, Ph.D.
Professor, TMHRI, Houston, TX

Amina A. Qutub, Ph.D.
Assistant Professor of Bioengineering, Rice University, Houston, TX

Richard E. Wainerdi, P.E., Ph.D.
President, Chief Executive Officer, Texas Medical Center, Houston, TX