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Physio - Horrigan Lab

Houston, Texas

A BCM research lab.
Physio - Horrigan Lab
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Publications

Ma, Z, K.Y. Wong and F.T. Horrigan (2008): An Extracellular Cu2+ Binding Site in the Voltage Sensor of BK and Shaker Potassium Channels. Journal of General Physiology, 131(5): 483-502.

Horrigan, F.T., and Z. Ma (2008): Mg2+ Enhances Voltage Sensor/Gate Coupling in BK Channels. Journal of General Physiology, 131(1): 13-32.
*Commentary by C.J. Lingle. "Mg2+-dependent Regulation of BK Channels: Importance of Electrostatics”. 131(1): 5-11.

Yang, H., L. Hu, J. Shi, K. Delaloye, F.T. Horrigan, and J. Cui (2007): Mg2+ mediates interaction between the voltage-sensor and cytosolic domain to activate BK channels. Proceedings of the National Academy of Science USA 104(46): 18270-18275.

Hou, S., Reynolds, M.F., Horrigan F.T., Heinemann, S.H. and Hoshi T. (2006): Reversible Binding of Heme to Proteins in Cellular Signal Transduction. (review) Accounts of Chemical Research 39(12): 918-924.

Ma, Z., X.J. Lou, and F.T. Horrigan. (2006): Role of charged residues in the S1-S4 voltage sensor of BK channels. Journal of General Physiology 127: 309-328.

Zhang, G., and F.T. Horrigan (2005): Cysteine modification alters voltage- and Ca2+-dependent gating of large conductance (BK) potassium channels. Journal of General Physiology 125: 213-236.

Horrigan, F.T., S.H. Heinemann, and T. Hoshi. (2005): Heme Regulates Allosteric Activation of the Slo1 BK Channel. Journal of General Physiology 126: 7-21, 2005
*Commentary by J López-Barneo and A Castellano "Multiple Facets of Maxi-K+ Channels: The Heme Connection" 126: 1-5, 2005.

Hu, L., Shi, J., Ma Z., Krishnamoorthy, G., Sieling, F., Zhang, G., Horrigan, F.T., Cui, J. (2003): Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ Channels. Proceedings of the National Academy of Science USA 100: 10488-93.

Horrigan, F.T., Aldrich, R.W. (2002): Coupling between Voltage Sensor Activation, Ca2+ Binding and Channel Opening in Large Conductance (BK) Potassium Channels. Journal of General Physiology 120: 267-305.
*Commentary by C.J. Lingle "Setting the stage for molecular dissection of the regulatory components of BK channels." 120(3):261-265.

Lou, X.J., Schena, M., Horrigan F.T., Lawn R.M. and Davis, R.W. (2001). Expression monitoring using cDNA microarrays. In Methods in Molecular Biology: Genomic Protocols. Eds. M.P. Starkey and R. Elaswarapu, 175: 323-40.

Horrigan F.T. , Cui J. and Aldrich R.W. (1999): Allosteric voltage-gating of potassium channels I: mSlo ionic currents in the absence of Ca2+. Journal of General Physiology 114: 277-304, 1999
*Commentary by S.W. Jones "A Plausible Model" 114: 271-275.

Horrigan F.T. and Aldrich R.W. (1999). Allosteric voltage-gating of potassium channels II: mSlo channel gating charge movement in the absence of Ca2+. Journal of General Physiology , 114: 305-336.

Lou, X.J., Boonmark,N.M., Horrigan F.T., Degan, J.L., and Lawn R.M. (1998). Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice. Proceedings of the National Academy of Science USA 95:12591-12595.

Horrigan F.T. and Gilly W.F. (1996). Methadone block of K current in squid giant fiber lobe neurons. Journal of General Physiology. 107:243-260

Horrigan F.T. and Bookman, R.J. (1994). Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells. Neuron 13:1119-1129.

Bookman, R.J. and F.T. Horrigan. (1993). Sampling characteristics of CCD video cameras. In Optical Microscopy: emerging methods and applications. Eds. Herman and Lemasters Academic Press.

Lucero, M.T., F.T. Horrigan, and W.F. Gilly. (1992). Electrical responses to chemical stimulation of squid olfactory receptor cells. J. Exp. Biol. 1 62, 231-249.

Gilly, W.F., M. T. Lucero, and F.T. Horrigan. (1990). Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid. Neuron 5:663-674.

INVENTIONS


Horrigan F.T. , Cannell M.B. and Bookman, R.J. A rapidly switching, filter-based excitation system for fluorescence microscopy. Licensed to Sutter Instrument Company and marketed as “Lambda DG-4 : ultra high speed wavelength switcher”.