Van den Veyver Lab
The Van den Veyver Laboratory is located at Baylor College of Medicine in the Texas Medical Center of Houston, TX.
Our research has three main areas of focus:
- We study the genetics of X-linked dominant disorders, Aicardi Syndrome and Goltz Syndrome (Focal Dermal Hypoplasia). We recently identified PORCN as the gene mutated in Goltz syndrome.
- We have a project investigating genetics of sporadic and recurrent hydatidiform moles. This is an abnormal development of pregnancy with disrupted imprinting. These disorders are an excellent model to investigate genomic imprinting in human placenta.
- Our third project seeks to understand the epigenetic changes that are at the basis of the developmental origin of adult disease (Barker Hypothesis). For this project we feed mice various diets during pregnancy and suckling, and study the long-term effects in the offspring using various molecular approaches.