Soo Lee Lab at BCM
Transcriptional Regulation in Neural Development and Metabolism
Our goal is to develop a comprehensive map of the complex gene regulatory networks that direct cell-fate specification and assembly of neuro-circuits. In particular, we are engaged in the fundamental aspects of mammalian transcriptional regulation, including the roles of transcriptional coregulators that function through chromatin remodeling and modification.
As model systems, we explore the neural developmental processes of mouse and chick embryos as well as the transcriptional regulatory basis for the development of two metabolic neurons in the arcuate nuclear region of the hypothalamus, orexigenic AgRP and anorexigenic POMC neurons. We also study their function in regulating appetite and energy expenditure.
"Our imagination is the only limit to what we can hope to have in the future" -Charles F. Kettering-