skip to content »

Leal Lab

Houston, Texas

The Cullen Building at Baylor College of Medicine.
Molecular and Human Genetics - Center for Statistical Genetics
not shown on screen

Kwanghyuk (Danny) Lee, Ph.D.

Kwanghyuk (Danny) Lee, Ph.D.

Contact Information

kl148313@bcm.edu

Research Interests

  • Gene Mapping using linkage analysis and association studies.
  • Methodological problems in statistical genetics.
  • The genetics of non-syndromic hearing impairment.

Education

Selected Publications

  1. Mendoza-Fandino G, Gee, J, Ben-Dor S, Gonzalez-Quevedo C, Leal K, Kobayashi Y, Hartiala J. Myers R, Leal SM, Allayee Hm Patel P. (2010) A novel g.-1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia. Clin Genet. Aug 12. PMID 21443745
  2. Borck G, Ur Rehman A, Lee K, Pogoda HM, Kakar N, von Ameln S, Grillet N, Hildebrand MS, Ahmed ZM, Nürnberg G, Ansar M, Basit S, Javed Q, Morell RJ, Nasreen N, Shearer AE, Ahmad A, Kahrizi K, Shaikh RS, Ali RA, Khan SN, Goebel I, Meyer NC, Kimberling WJ, Webster JA, Stephan DA, Schiller MR, Bahlo M, Najmabadi H, Gillespie PG, Nürnberg P, Wollnik B, Riazuddin S, Smith RJ, Ahmad W, Müller U, Hammerschmidt M, Friedman TB, Riazuddin S, Leal SM, Ahmad J, Kubisch C. (2011) Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42Am J Hum Genet. Feb 11;88(2):127-37. PMID 21255762
  3. Arnett J, Emery SB, Kim TB, Boerst AK, Lee K, Leal SM, Lesperance MM. (2011) Autosomal dominant progressive sensorineural hearing loss due to a novel mutation in th KCNQ4 gene. Arch Otolaryngol Head Neck Surg. Jan;137(1):54-9. PMID 21242547
  4. Ahmed ZM, Yousaf R, Lee BC, Khan SN, Lee S, Lee K, Husnain T, Rehman AU, Bonneux S, Ansar M, Ahmad W, Leal SM, Gladyshev VN, Belyantseva IA, Van Camp G, Riazuddin S, Friedman TB, Riazuddin S. (2011) Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. Am J Hum Genet. Jan 7;88(1):19-29. PMID 21185009
  5. Basit S, Lee K, Habib R, Chen L, Umm-E-Kalsoom, Santos-Cortez RL, Azeem Z, Andrade P, Ansar M, Ahmad W, Leal SM. (2011) DFNB89, a novel autosomal recessive nonsyndromic hearing impairment locus on chromosome 16q21-q23.2. Hum Genet. Apr;129(4):379-85. PMID 21181198
  6. Brunetti-Pierri N, Lachman R, Lee K, Leal SM, Piccolo P, Van Den Veyver IB, Bacino CA (2010) Terminal osseus dysplasia with pigmentary defects (TODPD): Follow-up of the first reported family, characterization of the radiological phenotype, and refinement of the linkage region. Am J Med Genet A. Jul;152A(7):1825-31. PMID 20583181
  7. Schraders M, Lee K, Oostrik J, Huygen PL, Ali G, Hoefsloot LH, Veltman JA, Cremers FP, Basit S, Ansar M, Cremers CW, Kunst HP, Ahmad W, Admiraal RJ, Leal SM, Kremer H. (2010) Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment. Am J Hum Genet. Feb 12;86(2):138-47. PMID 20137778
  8. Schultz JM, Khan SN, Ahmed ZM, Riazuddin S, Waryah AM, Chhatre D, Starost MF, Ploplis B, Buckley S, Velásquez D, Kabra M, Lee K, Hassan MJ, Ali G, Ansar M, Ghosh M, Wilcox ER, Ahmad W, Merlino G, Leal SM, Riazuddin S, Friedman TB, Morell RJ. (2009) Noncoding mutations of HGF Are associated with nonsyndromic hearing loss. Am J Hum Genet. Jul;85(1):25-39. PMID 19576567
  9. Chishti MS, Lee K, McDonald ML, Hassan MJ, Ansar M, Ahmad W, Leal SM. (2009) Novel autosomal recessive nonsyndromic hearing impairment locus (DFNB71) maps to chromosome 8p22-21.3. J Hum Genet. Mar;54(3):141-4. PMID 19229252
  10. Gajecka M, Radhakrishna U, Winters D, Nath SK, Rydzanicz M, Ratnamala U, Ewing K, Molinari A, Pitarque JA, Lee K, Leal SM, Bejjani BA.(2009) Localization of a gene for keratoconus to a 5.6-Mb interval on 13q32. Invest Ophthalmol Vis Sci. Apr;50(4):1531-9. PMID 19011015
  11. Bhatti A, Lee K, McDonald M-L, Wajid M, Ansar M, Ahmad W, Leal SM (2008): Mapping of a new autosomal recessive nonsyndromic hearing impairment locus (DFNB45) to chromosome 1q43-q44. Clin Genet. 73:395-8. PMID 18325041
  12. Chishti MS, Bhatti A, Tamim S, Lee K, M-L McDonald, Leal SM, Ahmad W (2008) Novel splice site mutations in TRIC gene underlies autosomal recessive nonsyndromic hearing impairment in three Pakistani families. J Hum Genet. 53:101-5. PMID 18084694
  13. Collin RWJ, Kalay E, Tariq M, Peters T, van der Zwaag B, Venselaar H, Oostrik J, Lee K, Ahmed ZM, Çaylan R, Li Y, Spierenburg HA, Eyupoglu E, Heister A, Riazuddin S, Bahat E, Arslan S, Wollnik B, Brunner HG, Cremers CWRJ, Karaguzel A, Ahmad W, Cremers FPM, Vriend G, Friedman TG, Riazuddin S, Leal SM, Kremer H (2008) Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal recessive nonsyndromic hearing impairment DFNB35. Am J Hum Genet. 82:125-38. PMID 18179891
  14. Wali A, Ali G, John P, Lee K, Chishti MS, Leal SM, Ahmad W. (2007) Mapping of a gene for alopecia with mental retardation syndrome (APMR3) on chromosome 18q11.2-q12.2. Ann Hum Genet. 71(Pt 5):570-7. PMID 17451405
  15. Wali A, John P, Gul A, Chishti MS, Lee K, Ali G, Hassan MJ, Leal SM, Ahmad W (2006) A novel locus for alopecia with mental retardation syndrome (APMR2) maps to chromosome 3q26.2-q26.31. Clin Genet. 70:233-9. PMID 16922726
  16. Mendoza G, Pemberton TJ, Lee K, Scarel-Caminaga R, Mehrian-Shai R, Gonzalez-Quevedo C, Ninis V, Hartiala J, Allayee H, Snead ML, Leal SM, Line SRP and Patel PI (2007) A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24.3. Hum Genet.120:653-62. PMID 17024372
  17. Santos RL, Hassan MJ, Sikandar S, Lee K, Ali G, Martin Jr. PE, Ahmad W, Leal SM (2006) DFNB68, a novel autosomal recessive nonsyndromic hearing impairment locus at chromosomal region 19p13.2. Hum Genet. 120:85-92. PMID 16703383
  18. Ali G, Santos RL, John P, Lee K, Ahmad W, Leal SM (2006) The mapping of DFNB62, a new locus for autosomal recessive nonsyndromic hearing impairment, to chromosome 12p13.2-p11.23. Clin Genet. 69:429-33. PMID 16650082
  19. Wang QJ, Li QZ, Rao SQ, Lee K, Yang WY, Zhai SQ, Guo WW, Guo YF, Yu N, Zhao YL, Yuan H, Guan J, Leal SM, Han DY, Shen Y (2006) AUNX1, a novel locus responsible for X-linked recessive and early-onset auditory neuropathy in an extended 5-generation Chinese family, maps to Xq23-27.3. J Med Genet. 43:33. PMID 16816020
  20. Naeem M, Jelani M, Lee K, Ali G, Shah W, Raza SI, Gul A, Muhammad Chisti MS, John P, Hassan MD, Leal SM, Ahmad W (2006) Ectodermal dysplasia of hair and nail type: mapping of a novel locus to chromosome 17p12-q21.2 and mutation analysis of candidate genes. Br J Dermatol. 155:1184-90. PMID 17107387
  21. El-Shanti H, Daoud A, Sadoon AA, Leal SM, Chen S, Lee K, Spiegel R (2006) A distinct autosomal recessive ataxia maps to chromosome 12 in an inbred family from Jordan. Brain Dev. 28:353-7.
  22. Tariq A, Santos RLP, Khan MN, Lee K, Hassan MJ, Ahmad W, Leal SM (2006) Localization of a novel autosomal recessive non-syndromic hearing impairment locus DFNB65 to chromosome 20q13.2-q13.32. J Mol Med. 84:484-90.
  23. Naeem M, Wajid M, Lee K, Leal SM, Ahmad W (2006) A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type. J Med Genet. 43:274-9.
  24. Santos RL, El-Shanti H, Sikandar S, Bhatti A, Yan K, Chahrour M, Lee K, Mahasneh AA, McArthur N, Pham TL, Ahmad W, Leal SM (2006) Novel sequence variants in the TMIE gene in families with autosomal recessive non-syndromic hearing impairment. J Mol Med. 84:226-231.
  25. Hassan MJ, Santos RL, Rafiq MA, Chahrour MH, Pham TL, Wajid M, Hijab N, Wambangco M, Lee K, Ansar M, Yan K, Ahmad W, Leal SM (2006) A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3. Hum Genet. 118:605-610.
  26. Santos RL, Wajid M, Khan M, McArthur N, Pham T, Bhatti A, Lee K, Irshad S, Mir A, Yan K, Chahrour M, Ansar M, Ahmad W, Leal SM (2005) Novel sequence variants in the TMC1 genes in Pakistani families with autosomal recessive hearing impairment. Hum Mut. 26:396.
  27. Irshad S, Santos RL, Muhammad D, Lee K, McArthur N, Haque S, Ahmad W, Leal SM (2005) Localization of a novel autosomal recessive non-syndromic hearing impairment locus DFNB55 to chromosome 4q12-q13.2. Clin Genet. 68:262-267.

E-mail this page to a friend