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Molecular and Human Genetics

Houston, Texas

Department of Molecular and Human Genetics
Department of Molecular and Human Genetics
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Lisa D. White, Ph.D.

Lisa D. White, Ph.D.

Associate Professor of Molecular and Human Genetics

Other Positions

Associate Professor, Department of Molecular & Cellular Biology
Director, Genomic & RNA Profiling Core, Baylor College of Medicine
Director, Genomic Profiling Shared Resource, Dan L. Duncan Cancer Center, Baylor College of Medicine
Director, High Throughput Genomic and RNA Analysis Core, Intellectual and Developmental Disabilities Research Center, Baylor College of Medicine
Director, Integrated Genomics Core, Diabetes Research Center, Baylor College of Medicine
Co-Director, Functional Genomics and Microbiome Core, Texas Medical Center Digestive Disease Center

Education

B.A., Baylor University, 1989
Ph.D., University of Houston, 1994
Postdoctoral Associate, University of Maryland Biotechnology Institute, 1996-1998

Research Interests

I am interested in genomic profiling technologies and how these technologies can be used to answer questions in cancer, especially the changes that occur at the genomic, transcriptomic, and regulatory levels. For example, utilizing high throughput sequencing platforms we can assay the entire genome with applications like mRNA-seq, smallRNA-seq, ChIP-seq, whole genome sequencing, etc. I am particularly interested in genomic changes that result in progression to metastasis in cancer models. These changes can be chromosomal (copy number gains and losses) that affect coding genes and, importantly, non-coding RNAs or microRNAs.

As Director of the Genomic & RNA Profiling Core at BCM, I support high throughput genomic and RNA profiling technologies for members of the BCM community and throughout the Texas Medical Center. We collaborate with users from the Dan L. Duncan Cancer Center, The BCM Diabetes Research Center, The Intellectual and Developmental Disabilities Research Center, and the Texas Medical Center Digestive Disease Center.

Selected Publications

  1. Ku BJ, Kim TH, Lee JH, Buras ED, White LD, Stevens RD, Ilkayeva OR, Bain JR, Newgard CB, Demayo FJ, Jeong JW (2012). Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile Acid synthesis. PLoS One 7(8): e42915. PubMed PMID: 22912762
  2. Li J, Harris RA, Cheung SW, Coarfa C, Jeong M, Goodell MA, White LD, Patel A, Kang SH, Shaw C, Chinault AC, Gambin T, Gambin A, Lupski JR, Milosavljevic A (2012). Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome. PLoS Genet. 8(5): e1002692. PubMed PMID: 22615578
  3. Homan EP, Rauch F, Grafe I, Lietman C, Doll JA, Dawson B, Bertin T, Napierala D, Morello R, Gibbs R, White L, Miki R, Cohn DH, Crawford S, Travers R, Glorieux FH, Lee B (2011). Mutations in SERPINF1 cause osteogenesis imperfecta type VI. J. Bone Miner. Res. 26(12): 2798-803. PubMed PMID: 21826736
  4. Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS (2011). Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. Oncogene 30(32): 3522-36. PubMed PMID: 21423204
  5. Franco HL, Lee KY, Rubel CA, Creighton CJ, White LD, Broaddus RR, Lewis MT, Lydon JP, Jeong JW, DeMayo FJ (2010). Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse. Biol. Reprod. 82(5): 991-9. PubMed PMID: 20130264
  6. Franco HL, Lee KY, Broaddus RR, White LD, Lanske B, Lydon JP, Jeong JW, DeMayo FJ (2010). Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. Biol. Reprod. 82(4): 783-90. PubMed PMID: 20056671
  7. Oshima J, Magner DB, Lee JA, Breman AM, Schmitt ES, White LD, Crowe CA, Merrill M, Jayakar P, Rajadhyaksha A, Eng CM, del Gaudio D (2009). Regional genomic instability predisposes to complex dystrophin gene rearrangements. Hum. Genet. 126(3): 411-23. PubMed PMID: 19449031
  8. Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, Zhang YW, Vande Woude GF, Giudice LC, Young SL, Lessey BA, Tsai SY, Lydon JP, DeMayo FJ (2009). Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc. Natl. Acad. Sci. U S A 106(21): 8677-82. PubMed PMID: 19439667
  9. Van den Veyver IB, Patel A, Shaw CA, Pursley AN, Kang SH, Simovich MJ, Ward PA, Darilek S, Johnson A, Neill SE, Bi W, White LD, Eng CM, Lupski JR, Cheung SW, Beaudet AL (2009). Clinical use of array comparative genomic hybridization (aCGH) for prenatal diagnosis in 300 cases. Prenat. Diagn. 29(1): 29-39. PubMed PMID: 19012303
  10. Bi W, Breman AM, Venable SF, Eng PA, Sahoo T, Lu XY, Patel A, Beaudet AL, Cheung SW, White LD (2008). Rapid prenatal diagnosis using uncultured amniocytes and oligonucleotide array CGH. Prenat. Diagn. 28(10): 943-9. PubMed PMID: 18792925
  11. Ou Z, Kang SH, Shaw CA, Carmack CE, White LD, Patel A, Beaudet AL, Cheung SW, Chinault AC (2008). Bacterial artificial chromosome-emulation oligonucleotide arrays for targeted clinical array-comparative genomic hybridization analyses. Genet. Med. 10(4): 278-89. PubMed PMID: 18414211
  12. Xiao W, Liu W, Li Z, Liang D, Li L, White LD, Fox DA, Overbeek PA, Chen Q (2006). Gene expression profiling in embryonic mouse lenses. Mol. Vis. 12: 1692-8. PubMed PMID: 17213798
  13. Koster MI, Lu SL, White LD, Wang XJ, Roop DR (2006). Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. Cancer Res. 66(8): 3981-6. PubMed PMID: 16618715
  14. Boerboom D, White LD, Dalle S, Courty J, Richards JS (2006). Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Cancer Res. 66(4): 1964-73. PubMed PMID: 16488995

Contact Information

Lisa D. White, Ph.D.
Department of Molecular and Human Genetics
Baylor College of Medicine
One Baylor Plaza, MS BCM225
Houston, TX, 77030, U.S.A.

Phone: 713-798-7607
Fax: 713-798-7610
E-mail:
Lab web site: Microarray Core Facility

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