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Genetics - BaSH Consortium

Houston, Texas

BCM faculty, staff and trainees are the heart of the organization.
Molecular and Human Genetics
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Meet Our Team

NIH U42 OD011174
Consortium for the production and cryopreservation of knockout mice

Monica Justice, Ph.D.

Monica Justice, Ph.D.
Director, Mouse Embryonic Stem Cell Core

Monica Justice, Ph.D., is professor of Molecular and Human Genetics at BCM and principal investigator of the production grant with co-principal investigator Dr. Francesco DeMayo, professor of Molecular and Cellular Biology at BCM.

Dr. Justice has a well-established program in mouse development and cancer genetics. She directed an NIH-U01 Center for Mouse Mutagenesis and Phenotyping for Developmental Defects, which established protocols for assessing the characteristics of many mouse organ systems (U01 HD39372). She is the director of BCM's Mouse Embryonic Stem (ES) Cell Core, which processes and expands ES cells for this project. She is a founding member of the International Mouse Phenotyping Consortium, a scientific advisor to the European Conditional Mouse Mutagenesis Project (EUCOMM), and to the EUMODIC consortium, a former advisor to The Jackson Laboratory Induced Mutant Resource and the EUMORPHIA consortium, and a current advisor to the Mouse Genome Informatics group and EUCOMMTools. She was a scientific advisor to establish mouse phenotyping cores within companies (Lexicon, Pfizer), as well as for the Academia Sinica in Taiwan. She co-organized and co-chaired with Wolfgang Wurst the NIH and European Commission jointly sponsored meeting on the "Future of Mouse Functional Genomics" held in Brussels in 2007, whose content sparked this program.

Mouse Embryonic Stem Cell Core

The Mouse ES Cell Core generates genetically engineered mice needed by researchers across the United States who are in pursuit of answers and cures for human disease. Core personnel assist investigators with projects to engineer mutations in the germ line and somatic tissues of mice by performing homologous recombination in ES cells. Services include electroporation, ROSA targeting, clone expansion, the generation of primary mouse ES cell lines and murine virus testing. Go to the Mouse Embryonic Stem Cell website.

Genetically Engineered Mouse Core

The GEM Core provides BCM investigators with advice and services requiring the manipulation of mouse gametes to facilitate research involving genetically engineered mice. The GEM Core provides the following services, which can be scheduled and tracked using Mouse Embryo Manipulation Services, MEMS: DNA microinjection (traditional transgene DNA constructs or BAC DNA into the one cell mouse embryo), ES cell microinjection into blastocysts, strain rederivation, and embryo cryopreservation for archiving of mouse strains. Go to the Genetically Engineered Mouse website.

Franco DeMayo, Ph.D.

Franco DeMayo, Ph.D.
Director, Genetically Engineered Mouse Core

Franco DeMayo, Ph.D., is the director of the Genetically Engineered Mouse (GEM) Core and Professor of Molecular and Cellular Biology. Dr. DeMayo has been the Director of the BCM GEM Core since its establishment. During the last 26 years, he has carried out research involving all aspects of genetically engineered animals including transgenic rats, rabbits and cattle. Dr. DeMayo's research investigates steroid hormone regulation of reproduction as well as the generation of preclinical animal models for cancer research. Dr. DeMayo is co-Director of the Center for Reproductive Research, a NIH funded Specialized Cooperative Centers Program in Reproduction and Infertility Research (U54 HD07495). He is also the PI on a Mouse Models for Human Cancer Consortium Grant that used GEM models (U01 CA105352).


U54 HG006348
Consortium for broad-based disease phenotyping of knockout mice

Dr. Monica Justice is the lead principal investigator on the phenotyping grant.

Mouse Neurobehavioral Core

Corey Reynolds, Ph.D.

Richard Paylor, Ph.D.
Core Director

Richard Paylor, Ph.D., professor of Molecular and Human Genetics and Neuroscience, is an expert in developing and assessing mouse neurobehavioral phenotypes. Dr. Paylor was involved in the first paper published in Science (1992) that described the behavioral responses of a knockout mouse. He has published numerous studies on the establishment of behavioral test batteries in mice and the effects of test history and test order, and studies of a variety of behavioral responses of inbred strains of mice. He is has been the director of BCM's Mouse Neurobehavioral Core for 14 years, and has been involved in the behavioral analysis of a wide variety of mutant mice resulting in over 80 publications describing a range of behavioral abnormalities. Dr. Paylor also served on a number of NIH-sponsored committees focused on modeling human behavioral abnormalities in mice. He has served as scientific advisor and consultant for a number of companies and foundations including PsychoGenics, Primal, Seaside Therapeutics, and Cure Huntington's Disease Initiative.

Advanced Technology Core Laboratories

The phenotyping grant includes many investigators that direct various Advanced Technology Core Laboratories.

Mouse Phenotyping CoreCorey Reynolds, Ph.D.

Corey Reynolds, Ph.D.
Core Director

The Mouse Phenotyping Core contains a multitude of testing capabilities for the assessment of mouse models from embryo to adult. Access to the MPC is open to all BCM and non-affiliated BCM investigators. Current equipment includes: MRI, CT, ultrasound, body composition/densitometry, indirect calorimetry, telemetry, and indirect blood pressure. Workstations for image reconstruction and data analysis are also available within the core. Go to the Mouse Phenotyping Core website.

Optical Imaging and Vital Microscopy Core

Mary Dickinson, Ph.D

Mary Dickinson, Ph.D.
Core Director

The Optical Imaging and Vital Microscopy Core offers equipment, training and support for vital and intravital imaging studies in cells, tissues, embryos and live mice. Available technologies include confocal microscopy, line scanning confocal microscopy, multispectral microscopy and two-photon microscopy using microscopes designed for live cell and live animal imaging. Go to the Optical Imaging and Vital Microscopy website.

RNA In Situ Hybridization Core

Cecilia Ljungberg, Ph.D

Cecilia Ljungberg, Ph.D.
Director

The RNA In Situ Hybridization Core provides services and equipment to determine gene expression patterns in rodent and human tissues. We can process and section tissue (frozen or paraffin), prepare labeled RNA probes, perform high-throughput in situ hybridization, image and quantify the gene expression levels. Go to the RNA In Situ Hybridization website.

Cytometry and Cell Sorting Core

Christine Beeton, Ph.D

Christine Beeton, Ph.D.
Director

Joel M. Sederstrom, MBS

The Cytometry and Cell Sorting Core provides training, instrumentation, technical expertise, and software for flow cytometric analyses and cell sorting. Go to the Cytometry and Cell Sorting Core website.


Animal Research at BCM

Baylor College of Medicine (BCM) is the only private Medical School in the Greater Southwest and is located within the largest medical center in the world, the Texas Medical Center (TMC) in Houston, Texas. The Center for Comparative Medicine (CCM) serves as the centralized animal care organization for BCM. Our animal care program is fully accredited by AAALAC International and supports cutting edge research in many areas including genetics, molecular biology, immunology, cancer, cardiovascular disease, neuroscience, childhood illnesses, and microbiomes. CCM works with a wide range of species and models for human disease and is supported by 150 professionals, including veterinarians, veterinary technicians, behavioral specialists, trainers, animal care technicians, and administrators. The CCM program also includes a full-service comparative pathology laboratory for diagnostic and research support. CCM is particularly dedicated to training and education and participates in a veterinary residency program designed to develop well-trained, compassionate veterinarians for the future. Research animals have allowed us to redefine the limits of the human condition and we consider it a privilege to work with them. CCM is committed to ensuring that all of our animals receive outstanding care.

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