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Genetics - BaSH Consortium

Houston, Texas

BCM faculty, staff and trainees are the heart of the organization.
Molecular and Human Genetics
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IMPC: International Mouse Phenotyping Consortium: The IMPC builds on the efforts of IKMC to produce knockout mice and carry out high-throughput phenotyping of each line in order to determine the function of every gene in the mouse genome. These mice will be preserved in repositories and made available to the scientific community representing a valuable resource for basic scientific research as well as generating new models for human diseases.

WTSI: Welcome Trust Sanger Institute: The Sanger Institute is a genome research institute primarily funded by the Wellcome Trust. We use large-scale sequencing, informatics and analysis of genetic variation to further our understanding of gene function in health and disease and to generate data and resources of lasting value to biomedical research.

MRC Harwell: Medical Research Council:

NIH Knockout Mouse Project (KOMP): The goal of the NIH-funded Knockout Mouse Project (KOMP) is to generate a comprehensive resource of null mutant alleles, with a reporter, using gene targeting mutagenesis in mouse strain C57BL/6. The purpose of the KOMP is to establish a resource repository to collect and archive the null mutant alleles, primarily in the form of cryo-preserved embryonic stem (ES) cells, as well as associated DNA constructs, and cryo-preserved embryos or live mice created by the KOMP. The successful KOMP repository should aim to become self-supporting over time.

MGI: Mouse Genome Informatics: MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.

KOMP: Knockout Mouse Project Repository: The KOMP Repository is the sole archive and distribution repository for vectors, ES cells, and mice generated by the KOMP mutagenesis centers. Supported by an NIH cooperative agreement (U42 mechanism) to the University of California, Davis (UCD) and its subcontractor, Children's Hospital Oakland Research Institute (CHORI), the KOMP Repository ensures the preservation, protection, availability, and accessibility of KOMP resources for use by the scientific community. The repository is built upon the closely linked infrastructure, technical support, and faculty expertise within the UCD Mouse Biology Program, Center for Comparative Medicine, the Schools of Medicine and Veterinary Medicine, and the CHORI-BACPAC Resource. UCD archives, maintains, and distribute ES cell clones, live mouse lines, and frozen embryos and sperm, while CHORI archives, maintains, and distribute all vectors.

IKMC: International Knockout Mouse Consortium: The International Knockout Mouse Consortium (IKMC) aims to mutate all protein-coding genes in the mouse using gene trapping and gene targeting in C57BL/6 ES cells. It consists of KOMP, EUCOMM, NORCOMM, and TIGM

IMPReSS: International Mouse Phenotyping Resource of Standardised Screens: IMPReSS (International Mouse Phenotyping Resource of Standardised Screens), the successor of EMPReSS, contains standardized phenotyping protocols which are essential for the characterization of mouse phenotypes. IMPReSS contains definitions of the phenotyping Pipelines and mandatory and optional Procedures and Parameters carried out and data collected by international mouse clinics following the protocols defined. This allows data to be comparable and shareable and ontological annotations permit interspecies comparison which may help in the identification of phenotypic mouse-models of human diseases.

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