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Molecular and Cellular Biology

Houston, Texas

Image 1: Ovulated mouse cumulus cell oocyte complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.; Image 2: By Yi LI, Ph.D.; Image 3: Mouse oocyte at meiosis I immunostained  for tubulin (red) phosphop38MAPK (green) and DNA (blue). By JoAnne Richards,  Ph.D.;  Image 4: Expanded cumulus cell ooctye ocmplex  immunostained for hyaluronan (red), TSG6 (green) and DAN (blue). By JoAnne  Richards, Ph.D.;  Image 5: Epithelial cells taken from a mouse  mammary gland were cultured in a dish and transduced with a retrovirus  expressing two genes. The green staining shows green fluorescent protein and the red  staining shows progesterone receptor expression. The nucleus of each cell is  stained blue. Photomicrograph taken at 200X magnification.  By Sandra L. Grimm,  Ph.D.; Image 6: Ovarian vasculature (red) is excluded from the granulosa cells (blue) within growing follicles (round structures); Image 7:  Ovulated mouse cumulus cell oocyte  complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.
Department of Molecular and Cellular Biology
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Dolores J. Lamb, Ph.D.

Dolores J. Lamb, Ph.D. photoProfessor
Departments of Urology and Molecular and Cellular Biology

Education

Ph.D.: The University of Texas Graduate School of Biomedical Sciences, San Antonio
Postdoctoral training: Baylor College of Medicine, Houston

Research Interest

Genetic Basis of Male Infertility/Androgen Receptor Mutations in Advanced Prostate Cancer
Current funded research studies in my laboratory focus upon the the molecular basis for male reproductive defects. We have just renewed a large program project grant to examine the genetic basis for male infertility. Studies focus on genomic instability and testicular failure in azoospermia and the consequences of these defects for the offspring conceived with the assisted reproductive technologies. Our goal is to define the molecular basis for developmental and functional defects leading to male infertility. We hope to one day use this information in a dynamic and, perhaps, therapeutic role for the male factor patient.
Transplantation of adult spermatogonial stem cells may provide one route to restoration of fertility for patients rendered sterile by chemotherapy or occupational or environmental exposure to reproductive toxins. Current research is focused on the identification and purification of adult spermatogenial stem cells and development of new methods to enhance germ cell transplantation and stem cell proliferation in vivo and in vitro. Recently, we identified Leydig stem cells present in the adult testis, as well.

Contact Information

Baylor College of Medicine
One Baylor Plaza
Houston, TX 77030

Selected Publications

  1. Lipshultz LI and Lamb DJ. (2007). Risk of transmission of genetic diseases by assisted reproduction. Nat Clin Pract Urol 4(9):460-461.
  2. Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ and Matzuk MM. (2007). Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Hum Mol Genet 15(23):3411-3419.
  3. Rohozinski J. Lamb DJ and Bishop CE. (2006). UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. Biol Reprod 74(4):644-651.
  4. King SR, Smith AG, Alpy F, Tomasetto C, Ginsberg SD and Lamb DJ. (2006). Characterization of the putative cholesterol transport protein metastatic lymph node 64 in the brain. Neuroscience 139(3):1031-1038.
  5. Falendar AE, Freiman RN, Geles KG, Lo KC, Hwang DS, Lamb DJ, Morris PL, Tjian R and Richards JS. (2005). Maintenance of spermatogenesis requires TAF4B, a gonad specific subunit of TFIID. Genes and Development 19(7):794-803.
  6. Lo KC, Brugh VM III, Parker M and Lamb DJ. (2005). Isolation and Enrichment of Murine Spermatogonial Stem Cells Using Rhodamine 123 Mitochondrial Dye. BiolReprod 72:767-771.
  7. Lo KC, Lei Z, Rao CV, Beck J and Lamb DJ. (2004). De novo testosterone production in luteinizing hormone receptor knockout mice after transplantation of Leydig stem cells. Endocrinology 145(9):4011–4015.
  8. Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H and Lamb DJ. (2003). Azoospermia in patients heterozygous for a mutation in SYCP3. Lancet 362:1714-1719.
  9. Matzuk MM and Lamb DJ. (2002). Genetic Dissection of Mammalian Fertility Pathways. (Invited Review). Nat Cell Biol. S1:41-49. Nature Medicine 8 (S1). S41-S49.

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