Wah Chiu, Ph.D.
Alvin Romansky Professor of Biochemistry and Molecular Biology
Departments of Biochemistry and Molecular Biology and Molecular and Cellular Biology
Ph.D.: University of California, Berkeley
Postdoctoral training: Lawrence Berkeley National Laboratory
Electron Cryomicroscopy of Molecular Machines and Cells
Dr. Chiu’s laboratory has pioneered various experimental and computational methods in biological cryo-electron microscopy (cryo-EM). He is the founding director of two NIH supported research Centers: National Center for Macromolecular Imaging (http://ncmi.bcm.edu/) and Center for Protein Folding Machinery (http://proteinfoldingcenter.org). Both Centers involve multiple investigators from diverse disciplines in biology, medicine, physics, chemistry, engineering and computing from different institutions and industries across the U.S. and oversea. His current research focuses on the structure determinations of molecular chapeonins, dsDNA viruses, virus-cell complexes and human platelet.
- Koyfman A Y, Schmid M F, Gheiratmand L, Fu CJ, Khant HA, Huang D, He CY and Chiu W. (2011). Structure of Trypanosoma brucei flagellum accounts for its bihelical motion. Proc Natl Acad Sci U S A 108: 11105-8. PMCID3131312.
- Cong Y, Schröder GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J and Chiu W.(2011). Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. The EMBO J 31(3): 720-730. PMCID 3273382
- Rochat RH, Liu X, Murata K, Nagayama K, Rixon FJ and Chiu W. (2011). Seeing the portal in herpes simplex virus type 1 B capsids. J Virol 85:1871-4. PMCID3028901
- Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC and Chiu W. (2011). 4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. The EMBO J. 30(18): 3854-3863. PMCID3173789
- Chang JT, Schmid MF, Haase-Pettingell C, Weigele PR, King JA and Chiu W. (2010). Visualizing the structural changes of bacteriophage Epsilon15 and its Salmonella host during infection. J Mol Biol 402: 731-740. PMCID 20709082
- Liu X, Zhang Q, Murata K, Baker ML, Sullivan MB, Fu C, Dougherty M, Schmid MF, Osburne MS, Chisholm SW and Chiu W. (2010). Structural changes in a marine Podovirus associated with release of its genome into Prochlorococcus. Nature Struct & Mol Bio. 17: 830-836. PMC2924429
- Zhang J, Baker ML, Schröder GF, Douglas NR, Reissmann S, Jakana J, Dougherty M, Fu CF, Levitt M, Ludtke SJ, Frydman J and Chiu W. (2010). Mechanism of folding chamber closure in a group II chaperonin. Nature 463: 379-383. PMCID2834796
- Jiang W, Baker ML, Jakana J, Weigele PR, King J and Chiu W. (2008). Backbone structure of the infectious epsilon15 virus capsid revealed by electron cryomicroscopy. Nature 451: 1130-4. PMCID: 18305544
- Jiang W, Chang J, Jakana J, Weigele P, King J and Chiu W. (2006). Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. Nature, 439: 612-6. PMCID1559657.
- Schmid MF, Sherman M, Matsudaira P and Chiu W. (2004). Structure of the acrosomal bundle. Nature, 431: 104-107.