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Molecular and Cellular Biology

Houston, Texas

Image 1: Ovulated mouse cumulus cell oocyte complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.; Image 2: By Yi LI, Ph.D.; Image 3: Mouse oocyte at meiosis I immunostained  for tubulin (red) phosphop38MAPK (green) and DNA (blue). By JoAnne Richards,  Ph.D.;  Image 4: Expanded cumulus cell ooctye ocmplex  immunostained for hyaluronan (red), TSG6 (green) and DAN (blue). By JoAnne  Richards, Ph.D.;  Image 5: Epithelial cells taken from a mouse  mammary gland were cultured in a dish and transduced with a retrovirus  expressing two genes. The green staining shows green fluorescent protein and the red  staining shows progesterone receptor expression. The nucleus of each cell is  stained blue. Photomicrograph taken at 200X magnification.  By Sandra L. Grimm,  Ph.D.; Image 6: Ovarian vasculature (red) is excluded from the granulosa cells (blue) within growing follicles (round structures); Image 7:  Ovulated mouse cumulus cell oocyte  complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.
Department of Molecular and Cellular Biology
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Research Overview

Research Facilities

The Department of Molecular and Cellular Biology occupies extensive, modern facilities that are generously equipped with a full range of instrumentation required for research in cellular, molecular, developmental, and endocrine biology.

Special facilities include core laboratories for recombinant DNA research, histopathology, multiple tissue culture facilities, laser scanning confocal microscopy, high throughput fluorescent microscopy, deconvolution microscopy, transmission and scanning electron microscopy, mass spectrometry, computer facilities for structural/computational biology, baculovirus/monoclonal antibody production, large and small scale immuno-isolation of protein complexes and viral vector production.

A modern transgenic mouse facility provides state-of-the-art technology to generate transgenic and knockout mutant mouse models that are used by many faculty and students. The high level of cooperation among the various departments and Centers at Baylor College of Medicine and the institutions of the Houston scientific community provide access to additional facilities.

Areas of Research:

  • Bioinformatics
  • Cancer Biology (Breast and Prostate)
  • Developmental Biology
  • Diabetes
  • Gene Expression
  • Gene Therapy
  • Hormone Action
  • Molecular Genetics
  • Neurobiology
  • Proteomics
  • Reproductive Biology
  • Stem Cell Biology
  • Translational Biology

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