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Molecular and Cellular Biology

Houston, Texas

Image 1: Ovulated mouse cumulus cell oocyte complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.; Image 2: By Yi LI, Ph.D.; Image 3: Mouse oocyte at meiosis I immunostained  for tubulin (red) phosphop38MAPK (green) and DNA (blue). By JoAnne Richards,  Ph.D.;  Image 4: Expanded cumulus cell ooctye ocmplex  immunostained for hyaluronan (red), TSG6 (green) and DAN (blue). By JoAnne  Richards, Ph.D.;  Image 5: Epithelial cells taken from a mouse  mammary gland were cultured in a dish and transduced with a retrovirus  expressing two genes. The green staining shows green fluorescent protein and the red  staining shows progesterone receptor expression. The nucleus of each cell is  stained blue. Photomicrograph taken at 200X magnification.  By Sandra L. Grimm,  Ph.D.; Image 6: Ovarian vasculature (red) is excluded from the granulosa cells (blue) within growing follicles (round structures); Image 7:  Ovulated mouse cumulus cell oocyte  complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.
Department of Molecular and Cellular Biology
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Arun Sreekumar, Ph.D.

Associate Professor
Department of Molecular and Cellular Biology

Education

Ph.D.: Indian Institute of Science, Bangalore, India
Postdoctoral training: University of Michigan Medical School, Ann Arbor

Research Interest

Metabolomic Profiling of Cancer Progression
Dr. Sreekumar’s research interests are in the areas of biomarker discovery and understanding pathway alterations during cancer development and progression. His work involves the use of high throughput metabolomics platforms as well as system’s based data integration using bioinformatic tools. His metabolomic projects are funded by RO1 and UO1 from NCI as well as funds from Susan Komen Foundation, CPRIT, Department of Defense and Alkek Foundation. The bioinformatics initiative is supported by a grant from the National Science Foundation.

In the area of metabolomics, Dr Sreekumar’s goal is develop multiplex metabolomic markers and biochemical pathways to study cancer development and progression. He was the lead author in paper on metabolomic profiling of prostate cancer that was published in Nature. He has since established an unbiased mass spectrometry-based metabolomic profiling platform to interrogate tumor metabolite. He is currently studying the metabolomic alterations in breast and bladder tumors as an extension of his earlier work on prostate. The workflow incorporates metabolomic evaluation of patient specimens, delineation of class-specific metabolic profiles, functional validation of pathways using invitroa and invivo model systems of the disease and development of non-invasive multiplex metabolic markers for detection and prognosis.

In addition, Dr. Sreekumar is also developing informatics tools to integrate matched OMICS datasets to study cancer progression from a systems perspective.

Contact Information

Baylor College of Medicine
One Baylor Plaza,
Houston, TX 77030

Phone: 713-798-3305
E-mail: sreekuma@bcm.edu

Selected Publications

  1. Putluri N, Shojaie A, Vasu VT, Vareed SK, Nalluri S, Putluri V, Thangjam GS, Panzitt K, Tallman CT, Butler C, Sana TR, Fischer SM, Sica G, Brat DJ, Shi H, Palapattu GS, Lotan Y, Weizer AZ, Terris MK, Shariat SF, Michailidis G, Sreekumar A. Metabolomic Profiling Reveals Impaired Detoxification Mechanism in Bladder Cancer. Cancer Research 2011, october 11 PMID: 21990318
  2. Putluri, N., Shojaie, A., Vasu, V., Nalluri, S., Vareed, S., Putluri, V., Vivekanandan-Giri, A., Byun, J., Pennathur, S., Sana, T., Fischer, S.M., Palapattu, G.S., Creighton, C.J., Michailidis, G., Sreekumar, A. Metabolomic Profiling Reveals A Role for Androgen in Activating Amino Acid Metabolism and Methylation in Prostate Cancer Cells. PLoS One. 2011;6(7):e21417. Epub 2011 Jul 18. PMID:21789170.
  3. Vareed SK, Bhat VB, Thompson C, Vasu VT, Fermin D, Creighton CJ, Gayatri S, Lan L, Putluri N, Thangjam GS, Kaur P, Shabahang M, Cashikar AG, Giri JG, Nesvizhskii AI, Asea AAA, Rao A, McLoughlin J and Sreekumar A. Metabolites of Purine Nucleoside Phosphorylase (NP) in Serum have the Potential to Delineate Pancreatic Adenocarcinoma. PLoS One. 2011 Mar 23;6(3):e17177. PMID:21448452
  4. Vellaichamy A, Dezso Z, JeBailey L, Chinnaiyan AM, Sreekumar A, Nesvizhskii AI, Omenn GS,
    Bugrim A. "Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen response. PLoS One. 2010 Jun 3;5(6):e10936.PMID: 20532174
  5. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn, GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C and Chinnaiyan AM. Metabolomic Profiles Delineate Potential Role for Sarcosine in Prostate Cancer Progression. Nature 2009 Feb12; 457(7231):910-4, PMID: 19212411
  6. Vellaichamy A, Sreekumar A*, Strahler J, Rajendiran TM, Yu J, Varambally S, Li Y, Omenn G, Chinnaiyan AM and Nesvizhskii A*. Proteomic Interrogation of Androgen Action in Prostate Cancer Cells Reveals Roles of Aminoacyl tRNA Synthetases. PLoS One. 2009 Sep 18;4(9):e7075.PMID:19763266 * joined Corresponding Authors.
  7. Khan AP, Poisson LM, Bhat V, Fermin D, Zhao R, Kalyana-Sundaram S, Michailidis G, Nesvizhskii AI, Omenn GS, Chinnaiyan AM, Sreekumar A. Quantitative proteomic profiling of prostate cancer reveals role for miR-128 in prostate cancer. Mol Cell Proteomics. 2009 Nov 9. PMID: 19955085
  8. Taylor B, Pal M, Yu J, Laxman B, Sundaram S, Zhao R, Menon A, Wei J, Nesvizhskii A, Ghosh D, Omenn G, Lubman D, Chinnaiyan A, and Sreekumar, A*. Humoral response profiling reveals pathways to prostate cancer progression. Molecular and Cellular Proteomics 2008 Mar;7(3):600-11. Epub 2007 Dec 11. PMID: 18077443. *Corresponding author
  9. Sreekumar A, Laxman B, Rhodes DR, Bhagavathula S, Giacherio G, Ghosh D, Sanda MG, Rubin MA, Chinnaiyan AM. (2004) Protein Microarray Analysis Reveals that Prostate Cancer Patients Elicit a Humoral Immune Response to  Methylacyl CoA Racemase. Journal of National Cancer Institute, 96(10) 834-843. PMID: 15173267.
  10. Wang X, Yu J, Sreekumar A, Varambally S, Shen R, Giacherio D, Mehra R, Montie J, Pienta K, Sanda M, Kantoff P, Rubin M, Wei J, Ghosh D, Chinnaiyan, A. Autoantibody Signatures in Prostate Cancer. New England Journal of Medicine: Sep 22;353(12):1224-35. PMID: 16177248

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