Karl-Dimiter Bissig, M.D., Ph.D.
Department of Molecular and Cellular Biology
M.D., Ph.D.: University of Bern, Switzerland
Postdoctoral training: The Salk Institute, La Jolla
Cell Based Therapy for Liver Disease
Regenerative medicine has been revolutionized by the induced pluripotent stem (iPS) cell technology and a lot of effort is spent in establishing autologous cell therapies. One of the major hurdles of this seemingly straightforward approach is the lack of suitable small animal models to validate the true nature of stem cell derived hepatocytes. Our laboratory has the opportunity to validate these hepatocytes and explore cell-based therapy in recently developed xenotransplantation model (Bissig et al. PNAS 2007). We are further developing novel genomic approaches to program stem cells into hepatocytes or even normal skin cells into hepatocytes (transdifferentiation).
Recent advancements led to a human liver chimerism of 95% and propagation of hepatitis B and C virus in these humanized mice (Bissig et al. Journal of Clinical Investigation 2010). One of the ongoing projects in our lab is the evaluation of a new class of antiviral drugs against viral hepatitis. This is a multicenter, NIH sponsored collaborative effort.
Baylor College of Medicine
One Baylor Plaza, N1010.07
Houston, TX 77030
- Ruiz S, Panopoulos A, Herrerías A, Bissig K-D, Berggren TW, Lutz M, Verma IM, Izpisua-Belmonte JC. (2011) High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity Curr Biol. 2011 Jan 11;21(1):45-52. PMID:21603572
- Bissig K-D, Wieland SF, Tran P, Isogawa M, Le TT, Chisari VF, Verma IM. (2011) Hepatitis B and C virus infection in the fah-/-/rag-2-/-/il-2rg-/- chimeric mouse model, J Clin Invest. 2010 Mar 1;120(3):924-30. PMID:21167714
- Bissig K-D, Le TT, Woods NB, Verma IM. (2007) Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model, Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20507-11. PMID: 20179355