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Department of Medicine - Winters Center

Houston, Texas

The staff of the Winters Center is engaged in translational research and clinical practice.
Winters Center for Heart Failure Research
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Current Studies

Evaluation of prognostic markers in heart failure within the va system: Development of a clinically useful model for predicting survival and hospitalization (H-10618)

Aldosterone antagonism in diastolic heart failure (H-11916)

Impact of diastolic heart failure on health care utilization and outcomes (H-12651)

A double-blind, randomized, placebo-controlled, multicenter study to assess the efficacy and safety of darbepoetin alfa treatment on mortality and morbidity in heart failure (HF) subjects with symptomatic left ventricular systolic dysfunction and anemia (H-19504)

The obesity paradox in heart failure (H-19946)

Warcef RC# 4165 warfarin versus aspirin in reduced cardiac ejection fraction (H-19844)

Phosphodiesterase-5 inhibition to improve clinical status and exercise capacity in diastolic heart failure: Amendment 3 March 11, 2011 (H-21891)

Cardiorenal rescue study in acute decompensate1D heart failure amendment 5 March 10, 2011: Carress HF study (H-22130)

HFN biorepository substudy protocol October 30, 2008 (H-24366)

Characterization of hemodynamics and evaluation of optimal treatment strategy in patients presenting with acute decompensated heart failure (ADHF) and worsening renal function (WRF). (H-24668)

HFN genomic/pharmacogenomic substudy October 30, 2008 (H-24784)

A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of both aliskiren monotherapy and aliskiren/enalapril combination therapy compared to enalapril monotherapy, on morbidity and mortality in patients with chronic heart failure (NYHA class II - IV) atmosphere trial (H-25065)

Prevalence, risk factors and health disparities of thoracic aortic aneurysms and dissections in veterans (H-25355)

Treatment of preserved cardiac function heart failure with an aldosterone antagonist (topcat) IND number: 71,883 version 1.7 – June 6, 2000 (H-25916)

Winters Center registry for heart failure patients (H-25969)

Winters Center bioregistry for heart failure patients Winters CTR bioregistry (H-25970)

Winters Center genomic registry for heart failure patients (H-25971)

The effect of nebivolol on myocardial glucose uptake and load independent indices of left ventricular contractile function in patients with heart failure (H-26017)

Xanthine oxidase inhibition for hyperuricemic heart failure patients: Exact-HF amendment 1 June 30, 2010 protocol for the heart failure clinical research network (H-26114)

A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of CLCZ696 compared to enalapril on morbidity and mortality in patients with chronic heart failure and reduced ejection fraction version 01, September 10, 2009 (H-26187)

Development of a lab-on-a-chip system for saliva-based diagnostics nidcr protocol number: 09-018-e version 7.0 January, 03 2013 (H-26238)

Pilot study for assessment of salivary biomarkers using different saliva collection kits and pooled saliva in patients with chest pain (H-26446)

Renal optimization strategies evaluation in acute heart failure (rose –AHF), amendment 1, March 24, 2011 (H-27152)

Reliable evaluation of dyspnea in the heart failure network rose study May 4, 2011 (H-28949)

A double-blind, randomized, placebo-controlled, multicenter study to evaluate the safety and efficacy of iv infusion treatment with omecamtiv mecarbil in subjects with left ventricular systolic dysfunction hospitalized for acute heart failure AMG 423 (omecamtiv mecarbil) – atomic AHF(acute treatment with omecamtiv mecarbil to increase contractility) (H-30410)

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