Natarajan Sivasubramanian, Ph.D.
Department of Medicine - Cardiology - Baylor College of Medicine
Associate Professor of Medicine
Baylor College of Medicine
Co-Director, Integrative Biology Core Laboratories
Winters Center for Heart Failure Research
1102 Bates street
Feigin Center, Rm.C0430.03
Houston TX 77030
The major focus of Dr. Sivasubramanian's laboratory is to characterize the Nuclear Factor of Kappa B (NFkB) transcriptional control mechanism(s) which occur in the failing human heart. NFkB is a stress responsive cytoprotective transcription factor involved in regulating the expression of vital genes during organ injury. Our research efforts have focused on understanding the functions of a novel intracellular protein called Myo/V1 (earlier known as myotrophin and V-1) as well as determining the mechanism of NFkB activation during heart failure. Cardiac MyolV1 is a novel 12 kD protein ubiquitiously expressed in all mammalian organs, was first detected as an intracellular protein elevated in hypertrophied rat heart tissues and later in failing human heart tissues. Recently, my laboratory has identified a NFkB transcriptional regulatory function for this protein. By studying and characterizing the proteins which modulate NFKB transcriptional activity, our laboratory is trying to understand how NFkB proteins are activated during myocardial injury and during heart failure. In addition, my laboratory is focusing on how NFKB regulates the expression of various myocardial genes during heart failure. Given that many myocardial diseases are accompanied by altered NFKB signaling events these studies may one day translate into new therapies designed to protect the heart against injury.
Education and Training:
Ph.D. in Molecular Biology, Madurai Kamaraj University, Madurai, Tamil nadu, India
Edna-Lievre Fellow (Post-Doctoral Research) of the American Cancer Society, UCLA School of Medicine, Los Angeles, CA
Transcriptional mechanisms and its regulation in the failing heart.
- Knuefermann P, Chen P, Misra A, Shi SP, Abdellatif M, Sivasubramanian N. Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. J Biol Chem. 2002 Jun 28;277(26):23888-97
- Sivasubramanian N. Adhikary G. Sil PC, Sen S.: Cardiac myotrophin exhibits reUINF-kappa B interacting activity in vitro. J Biol Chem. 1996; 271 (5):2812-6
- Sivasubramanian N, Coker ML, Kurrelmeyer KM, MacLellan WR, DeMayo FJ, Spinale FG, Mann DL. Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 2001;104(7):826-31