Yuandong Peng, Ph.D.
Education and Training
Ph.D.: Chinese Academy of Sciences, Shenyang, Liaoning, China, 1998
Post-doctoral: Chinese Academy of Sciences, Shenyang, Liaoning, China, 2000; Vanderbilt University Medical Center, Nashville, TN, 2002
The formation of platelet thrombi at high shear stress is initiated by the binding of the platelet receptor, glycoprotein (GP) Ib-IX complex, to its ligand, von Willebrand factor (VWF). This receptor-ligand interaction is essential for tethering platelets to the injured vessel wall as a prerequisite for integrin-mediated firm arrest. A malfunction in this interaction causes either Bernard-Soulier Syndrome (BSS) or platelet-type von Willebrand disease (VWD). Recently we began to realize that platelet membrane lipid domains are essential for the normal function of the GP Ib-IX complex.
Current focus of our laboratory is to elucidate the mechanism for the complex association with platelet lipid domain, which we believe may provide novel insights into GP Ib-IX complex function regulation, and help to develop strategies to treat thrombotic diseases.