Vinod K. Vijayan, Ph.D.
Office Address: Alkek N1317.07
Phone Number: 713-798-8677
Education and Training:
Ph.D.: Cancer Research Institute, University of Mumbai, Mumbai, India, 1997
Postdoc Training: Johns Hopkins University School of Medicine, Baltimore, Maryland, 2000
Serine/Threonine phosphatases in platelet and endothelial activation
Integrin aIIbb3 is central to the ability of platelets to participate in the process of hemostasis and thrombosis. Indeed, coupling of the signaling machinery with the integrin initiates signaling and markedly influences platelet physiology. Signaling is manifested as reversible phosphorylation of tyrosine (Tyr) or Serine/Threonine (Ser/Thr) residues on multiple proteins. The net Tyr or Ser/Thr phosphorylation of a protein substrate is regulated by the activities of both protein kinases and protein phosphatases. The focus of my laboratory is to employ multi-disciplinarily approaches and decipher the mechanisms by which protein Ser/Thr phosphatases regulate integrin activation, signaling, and function in various model systems including human platelets, phosphatase null murine platelets, phosphatase silenced murine megakaryocytes and 293/aIIbb3 heterologous cells. A long term goal from a clinical perspective is to identify phosphatases, their regulators, or proteins that direct the phosphatases to a particular subcellular location as additional targets for future therapeutic interventions in thrombotic and inflammatory diseases.