Farrah Kheradmand, M.D.
Professor of Medicine and Immunology
Baylor College of Medicine
One Baylor Plaza - BCM520B
Houston, Texas 77030
- M.D., George Washington University, Washington, D.C.
- Residency, Internal Medicine, University of Minnesota Medical School, Minneapolis, Minn.
- Fellowship, Pulmonary and Critical Care, University of California at San Francisco, San Francisco, Calif.
Dr. Kheradmand's research is focused on understanding the role of innate and adaptive immune cells in the pathogenesis of chronic inflammatory lung diseases in particular, in human chronic obstructive pulmonary disease (COPD) and asthma. Her laboratory's ongoing research has elucidated the critical role that is played by several members of the matrix metalloproteinase (MMP) family in lung inflammation. They have made several seminal observations in the field of allergic airway inflammation (asthma) that include identifying the distinct contributions of MMP2 and MMP9 in regulating clearance of allergic inflammatory cells in the lung. In addition to work on experimental asthma, her laboratory has successfully established human translational research studies in tobacco-smoke related lung disease (COPD and emphysema). Their recent studies have shown the critical role for T cells and Th1 cytokines and chemokines in particular, gamma interferon and CXCL-10 (IP-10), in upregulation of MMP12 that is linked to the development of emphysema. Their translational studies aim to dissect the more proximal molecular and cellular events that lead to the pro-elastolytic lung environment induced by tobacco smoke. Their published studies are among the first to suggest an adaptive immune basis to human COPD/emphysema.
Her clinical interests include chronic obstructive pulmonary disease (COPD) and emphysema.
Awards and Honors
- American Society of Clinical Investigation, 2006
- Recipient of the Choa Scholar Award, Baylor College of Medicine, 2002
- Mentored Clinician Scientist Award (K08) NHLBI, 1998-2002
- American Lung Association Research Fellowship, 1995-1997
- Kheradmand F, Shan M, Corry DB. Smoking gun: mature dendritic cells in human lung provide clues to COPD. Am J of Resp Cell and Mol Biol. 2009. [In Press]
- Shan M, Cheng HF, Song LZ, Roberts L, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Storness-Bliss C, Ramchandani, M, Lee, SH, Corry, DB, Kheradmand, F. Lung myeloid dendritic cells coordinately induce Th1 and Th17 responses in human emphysema. Science Translational Medicine. 2009; 1(4):4ra1.
- Porter P, Susarla SC, Polikepahad S, Qian Y, Hampton J, Kiss A, Vaidya, S.Sur, S. Delclos, G.L. Abramson S, Kheradmand F, Corry, DB. Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi. Mucosal Immunol. 2009; 2(6):504-17.
- Corry DB, Kheradmand F. Toward a comprehensive understanding of allergic lung disease. Trans Am Clin Climatol Assoc. 2009; 120:33-48.
- Goswami S, Angkasekwinai P, Shan M, Greenlee KJ, Barranco WT, Polikepahad S, Seryshev A, Song LZ, Redding D, Singh B, Sur S, Woodruff P, Dong C, Corry DB, Kheradmand F. Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol. 2009; 10(5):496-503.
- Kheradmand F, Mattewal AS, Corry DB. At last, an immune organ we can call our own? Am J Respir Crit Care Med. 2009; 179(7):525-7.
- Kheradmand F, Corry DB. Discovery of novel markers in allergic lung inflammation through proteomic-based technologies. Expert Rev Proteomics. 2008; 5(1):9-12.
- Corry DB, Kheradmand F. A new link to airway obstruction in asthma. Nat Med. 2007; 13(7):777-8.
- Kiss A, Montes M, Susarla S, Jaensson EA, Drouin SM, Wetsel RA, Yao Z, Martin R, Hamzeh N, Adelagun R, Amar S, Kheradmand F, Corry DB. A new mechanism regulating the initiation of allergic airway inflammation. J Allergy Clin Immunol. 2007; 120(2):334-42.
- Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight-White S, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Cogswell S, Storness-Bliss C, Corry DB, Kheradmand F. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med. 2007; 13(5):567-9.