Youbao Sha, Ph.D.
Instructor of Medicine
Baylor College of Medicine
One Baylor Plaza - BCM285
Houston, Texas 77030
- M.S., Microbiology, Yunnan University, Yunnan, P. R. China
- Ph.D., Genetics, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, P. R. China
- Postdoctoral Associate, Medicine/Pulmonary, Baylor College of Medicine, Houston, Texas
Dr. Youbao Sha's research involves conduction investigations on two major projects. The first project is aimed at understanding the molecular mechanisms of how cells make triage decision for iNOS degradation and how the specificity of the degradation process is determined. This information would be critical for any therapeutic strategy aiming at modulating cellular iNOS activity and NO production. The project involves the use of the new and advanced technologies of genomics and expression arrays to trace the genome-wide gene expression alteration. Specifically, his first project focuses on molecular and cellular analysis of CHIP's (C-terminal Hsp-interacting protein) role in posttranslational regulation of iNOS by ubiquitin-proteasome degradation pathway and aggresome sequestration pathway.
Dr. Youbao Sha's second project involves studying on autophagic cell death by high-throughput screening of mouse whole genome using a lentivirus mediated siRNA library. Specifically, his second project's aims are : (1) identify genes involved in regulating of autophagic cell death by genome-wide screen using lentivirus based shRNA library in mouse macrophage; (2) study the molecular mechanism of the candidate gene (s) in the regulation of autophagic tumor suppressor network; and (3) study the functional role of autophagic cell death in cancer. Together, Dr. Sha's studies will dissect the fundamental mechanism involved in regulation of autophagic tumor suppression.
Awards and Honors
- DiAo Scholarship, Chinese Academy of Sciences, 1999-2003
- Institute Chief Award, Chinese Academy of Sciences, 1999-2003
- Excellent Cadre of Students, Yunnan University, 1996-1997
- Scholarship for outstanding students, Yunnan University, 1994-1995
- Scholarship for outstanding students, Yunnan University, 1992-1993
- Sha Y, Pandit L, Zeng S, Eissa NT. A critical role for CHIP in the aggresome pathway. Mol Cell Biol. 2009; 29(1):116-28.
- Sha Y, Li S, Pei Z, Luo L, Tian Y, He C. Generation and flanking sequence analysis of a rice T-DNA tagged population. Theoretical and Applied Genetics (TAG). 2004; 108(2):306-14.
- Sha Y, Li G, Wang J, Cui S, Ding H. Preliminary report on establishment of fungus disease-resistant rape breeding system by agrobacterium-mediated transformation. Journal of Yunnan University （Natural Sciences). 1999; 21(3):209-12.
- Cheng L, Sha T, Ding H, Sha Y, Wang H. The isolation and screening of lactobacillus acibophilus in human intestine. Journal of Yunnan University （Natural Sciences）. 1998; 20(2):108-11.