Matthew H. Wilson, M.D., Ph.D.
B.S. 1994 Georgetown College, Georgetown, KY
M.D., Ph.D., 2001 Vanderbilt University, Nashville, TN
Residency 2001-2003, Internal Medicine, Vanderbilt University, Nashville, TN
Fellowship 2003-2006, Nephrology/Genetic Medicine, Vanderbilt University, Nashville, TN
- Gene delivery to the kidney in vivo including gene therapy approaches for inherited renal diseases such as Alport’s syndrome (the most common inherited glomerular disease in man) and cystinura (a proximal tubular defect). These studies will lay the foundation for gene therapy directed at more common diseases such as diabetic and hypertensive nephropathies.
- Manipulating and harnessing non-viral transposon systems for gene delivery in vivo. Current studies are directed at the piggyBac transposon system and improving its use and safety in gene transfer applications. Additionally, there is interest in utilizing this very efficient system in other cell types and systems which are as of yet unexplored.
- Evaluation of multiple different strategies directed at achieving targeted integration of therapeutic genetic cargo into the mouse and human genomes. This includes delineation of “low-risk” genomic sites for targeted integration.
- Wilson MH, Coates CJ, George, AL. PiggyBac-transposon mediated gene transfer in human cells. Mol Ther 2007, 15: 139-145.
- Wilson MH, Kaminski JM, George AL. Functional Zinc Finger/Sleeping Beauty Transposase Chimeras Exhibit Attenuated Overproduction Inhibition. FEBS Lett 2005, 579: 6205-9.
- Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE. Heterozygous alpha2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proc Natl Acad Sci USA 2002, 99: 12471-6.
- Wilson MH, Highfield HA, Limbird LE. The role of a conserved inter-transmembrane domain interface in regulating alpha2A-adrenergic receptor conformational stability and cell-surface turnover. Mol Pharm 2001, 59: 929-38.
- Wilson MH, Limbird LE. Mechanisms regulating the cell surface residence time of the alpha2A-adrenergic receptor. Biochemistry 2000, 39: 693-700.