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Medicine - Mitsiades Lab

Houston, Texas

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Medicine - Mitsiades Lab
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The Mitsiades Lab Projects

Ongoing projects:

  • Targeting the mechanisms involved in hormonal regulation of prostate cancer by androgen
  • Exploring the role of the E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) in prostate cancer
  • Identifying clinically applicable inhibitors of the expression and/or function of steroid receptor coactivators
  • Targeting the mechanisms involved in hormonal regulation of breast cancer by estrogen
  • Investigating the mechanisms involved in the anticancer activity of the diabetes drug metformin and the lipid-lowering drugs HMG-CoA reductase inhibitors (statins)
  • Targeting the signaling pathways triggered by somatic mutations in the G protein α subunits Gαq and Gα11 (encoded by the genes GNAQ and GNA11, respectively) in uveal melanomas
  • Exploring novel therapies for thyroid cancer

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