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Section of Infectious Diseases

Houston, Texas

BCM pediatricians care for children in various clinical and hospital environments.
Section of Infectious Diseases
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Herbert L. DuPont, M.D.

Herbert L. DuPont, M.D.Clinical Professor of Medicine
Vice Chair, Department of Medicine
Chief of Medicine, St. Luke's Episcopal Hospital

Education

A.B., Ohio Wesleyan University, 1961
M.D., Emory University School of Medicine, 1965

Residency

Medical Internship, University of Minnesota Hospitals, 1965-1966
Medical Residency, Internal Medicine, University of Minnesota Hospitals, 1966-1967

Fellowship

Fellowship, Infectious Diseases - University of Maryland School of Medicine, 1967-1969

Board Certification

Internal Medicine

Specialty

Internal Medicine

Research Interest

The major focus of Dr. DuPont's research has been to couple laboratory research techniques with application to population studies in the field to study acute infectious diarrhea. Most studies have taken place in countries outside the United States: Mexico, Peru, Egypt, Jamaica, Zambia, Thailand, Kenya and India. A volunteer program was established in Houston to study enteric infectious diseases in humans where the emphasis or research direction has dealt with immunology and pathogenesis of disease. Major foci of the international studies have been on the epidemiology, immunology, clinical features, control, prevention and therapy of selected diarrheal diseases with public health implications. The approaches taken are practical and have clinical applicability. Basic science projects are performed as needed to help fully develop the larger questions suggested by field and laboratory research. Major current interests include studies of the pathogenesis and etiology of travelers’ diarrhea, Clostridium difficile diarrhea and colitis and post-infectious irritable bowel syndrome.

Publications and Books

Publications since 2006 (Original Articles):
  1. Jiang, Z-D, DuPont, HL, Garey, K, Price, M, Graham, G, Okhuysen, P, Dao-Tran, T, LaRocco, M. A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea. Amer J Gastroenterol 2006;101:1-5.
  2. Long, KZ, Estrada-Garcia, T, Rosado, JL, Santos, JI, Haas, M, Firestone, M, Bhagwat, J, Young, C, DuPont, HL, Hertzmark, E, Nanthakumar, NN. The effect of vitamin A supplementation on the intestinal immune response in Mexican children is modified by pathogen infections and diarrhea. J Nutr 2006;136:1365-1370.
  3. Bundy, JK, Gonzalez, VR, Barnard, BM, Hardy, RJ, DuPont, HL. Gender risk differences for surgical site infections among a primary coronary artery bypass graft surgery cohort: 1995-1998. Amer J Infect Control 2006;34:114-121.
  4. Ko, GP, Jiang, Z-D, Okhuysen, PC, DuPont, HL. Fecal cytokines and markers of intestinal inflammation in international travelers with diarrhea due to noroviruses. J Med Virol 2006;78:825-828.
  5. Taylor, DN, Bourgeois, AL, Ericsson CD, Steffen, R, Jiang, Z-D, Halpern, J, Haake, R, DuPont, HL. A randomized, double-blind, multicenter study of rifaximin compared with placebo and with ciprofloxacin in the treatment of travelers’ diarrhea. Amer J Trop Med Hyg 2006;74:1060-1066.
  6. Musher, DM, Logan, N, Hamill, RJ, DuPont, HL, Lentnek, A, Gupta, A, Rossignol, J-F. Nitazoxanide for the treatment of Clostridium difficile colitis. Clin Infect Dis 2006;15:421-427.
  7. Garey, KW, Graham, G, Gerard, L, Dao, T, Jiang, Z-D, Price, M, DuPont, HL. Prevalence of diarrhea at a university hospital and association with modifiable risk factors. Ann Pharmacother 2006;40:40:1030-1034.
  8. Garcia, C, DuPont, HL, Long, KZ, Santos, JI, Ko, G. Asymptomatic norovirus infection in Mexican children. J Clin Micro 2006;44:2997-3000.
  9. Huang, DB, Nataro, JP, DuPont, HL, Kamat, PP, Mhatre, AD, Okhuysen, PC, Chiang, T. Enteroaggregative Escherichia coli is a cause of acute diarrheal illness: a meta-analysis. Clin Infect Dis, 2006;43:556-563.
  10. Long, KZ, Santos, JI, Rosado, JL, Lopez-Saucedo, C, Thompson-Bonilla, R, Abonce, M, DuPont, HL, Hertzmark, E, Estrada-Garcia, T. Impact of vitamin A on gastrointestinal pathogen infections and associated diarrheal episodes among children in Mexico City, Mexico. J Infect Dis 2006;194:1217-1225.
  11. Long, KZ, Santos, JI, Estrada-Garcia, T, Haas, M, Firestone, M, Bhagwat, J, DuPont, HL, Hertzmark, E, Rosado, JL, Nanthakumar, NN. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children. J Nutr 2006;136:2600-2605.
  12. Cabada, MM, Maldonado F, Quispe, W, Mozo, K, Serrano, E, Gonzalez, E, Seas, C, Verdonck, K, Echevarria, JI, DuPont, HL, Gotuzzo, E. Risk Factors associated with diarrhea among international visitors to Cuzco, Peru. Am J Top Med Hyg 2006;75:968-972.
  13. Turner, SM, Chaudhuri, RR, Jiang, Zhi-Dong, DuPont, HL, Gyles, C, Penn, CW, Pallen, MJ, Henderson, IR. Phylogenetic comparisons reveal multiple acquisitions of the toxin genes by enterotoxigenic Escherichia coli strains of different evolutionary lineages. J Clin Microbiol 2006;44:4528-4536.
  14. Mohamed, JA, Huang, DB, Jiang, Z-D, DuPont, HL, Nataro, JP, Belkind-Gerson, J, Okhuysen, PC. Association of putative enteroaggregative Escherichia coli virulence genes and biofilm production in isolates from U.S. travelers to developing countries. J Clin Microbiol 2006;45:121-126.
  15. Price, MF, Dao-Tran, T, Garey, KW, Graham, G, Gentry, LO, Dhungana, L, DuPont, HL. Epidemiology and incidence of Clostridium difficile-associated diarrhoea diagnosed upon admission to a university hospital. J Hosp Infect 2007;65:42-46.
  16. DuPont, HL, Haake, R, Taylor, DN, Ericsson, CD, Jiang, Z-D, Okhuysen, P, Steffen, R. Rifaximin treatment of pathogen-negative travelers’ diarrhea. J Travel Med 2007;14:16-19.
  17. Mohamed, JA, DuPont, HL, Jiang, Z-D, Belkind-Gerson, J, Figueroa, JF, Armitige, LY, Tsai, A, Nair, P, Martinez-Sandoval, FJ, Guo, D, Okhuysen, PC. A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Clin Infect Dis 2007;44:945-952.
  18. Long, KZ, Rosado, JL, DuPont, HL, Hertzmark, E, Santos, JI. Supplementation with vitamin A reduces watery diarrhea and respiratory infections in Mexican children. Brit J Nutr 2007;97:337-343.
  19. DuPont, HL, Jiang, Z-D, Belkind-Gerson, J, Okhuysen, PC, Ericsson, CD, Ke, S, Huang, DB, DuPont MW, Adachi, JA, de la Cabada, FJ, Taylor, DN, Jaini, S, Martinez Sandoval, F. Treatment of travelers’ diarrhea: Randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone. Clin Gastroenterol Hepatology 2007;5:451-456.
  20. Ericsson, CD, DuPont, HL, Okhuysen, PC, Jiang, A-D, DuPont, MW. Loperamide plus azithromycin more effectively treats travelers’ diarrhea in Mexico than azithromycin alone. J Travel Med 2007;14:5 312-319.
  21. Jiang, Z-D, Garey, KW, Price, M, Graham, G, Okhuysen, PC, Dao-Tran, T, LaRocco, M, DuPont, HL. Association of interleukin-8 polymorphism and immunoglobulin G anti-toxin A in patients with Clostridium difficile associated diarrhea. Clin Gastroenterol Hepatology 2007;5:964-968.
  22. Long, KZ, Garcia, C, Santos, JI, Rosado, JL, Hertzmark, E, DuPont, HL, Ko, GP. Vitamin A supplementation has divergent effects on Norovirus infections and clinical symptoms among Mexican children. J Infect Dis 2007;196:978-985.
  23. Huang, DB, Mohamed, JA, Nataro, JP, DuPont, HL, Jiang, Z-D, Okhuysen, PC. Virulence characteristics and the molecular epidemiology of enteroaggregative Escherichia coli isolates from travelers to developing countries. J Med Micro 2007 56:1386-1392.
  24. Long, KZ, Rosado, JL, Montoya, Y, de Lourdes Dolano, M Hertzmark, E, DuPont, HL, Santos, JI. Effect of vitamin A and zinc supplementation on gastrointestinal parasitic infections among Mexican children. Pediatrics 2007;120:846-855.
  25. Garcia, C, Samalvides, F, Vidal, M, Gotuzzo, E, DuPont, HL. Epidemiology of Clostridium difficile-associated diarrhea in a Peruvian tertiary care hospital. Amer J Trop Med Hyg 2007;77:802-805.
Reviews, Case Reports and Book Chapters:
  1. Valdez, LM, Gotuzzo, E, Thielman, NM, DuPont, HL. Gastrointestinal Symptoms. (Chapter 123) Tropical Infectious Diseases Principles, Pathogens, & Practice, 2nd Edition, Eds. Guerrant, RL, Walker, DH, Weller, PF., Churchill Livingstone, Elsevier, Philadelphia, PA, 2006;1446-1458.
  2. Adachi, JA, DuPont, HL Rifaximin: A novel nonabsorbed rifamycin for gastrointestinal disorders. Clin Infect Dis 2006;42:541-547.
  3. DuPont, AW, DuPont, HL. Travelers’ diarrhea: Modern concepts and new developments. Curr Treat Options Gastroenterol 2005;9:13-21.
  4. DuPont, HL. Travellers’ diarrhoea: Contemporary approaches to therapy and prevention. Drugs 2006;66:303-314.
  5. Hill, DR, Ericsson, CD, Pearson, RD, Keystone, JS, Freedman, DO, Kozarsky, PE, DuPont, HL, Bia, FJ, Fischer, PR, Ryan, ET. The practice of travel medicine: Guidelines by the Infectious Diseases Society of America. Clin. Infect Dis, 2006;43:1499-1539.
  6. Pacheco-Gil, L, Ochoa, TJ, Flores-Romo, L, DuPont, HL, Estrada-Garcia, T. Enteroinvasive Escherichia coli severe dysentery complicated by rotavirus gastroenteritis. J Infect, 2006;53:211-213.
  7. DuPont, HL, Jiang, Z-D, Okhuysen, PC, Ericsson, CD, de la Cabada, FJ, Ke, S, DuPont, MW, Martinez-Sandoval, F. Antibacterial chemoprophylaxis in the prevention of traveler’s diarrhea: Evaluation of poorly absorbed oral rifaximin. Clin Infect Dis 2005;41:S571-S576.
  8. Koo, HL, DuPont, HL. Current and future developments in travelers’ diarrhea therapy. Expert Rev Anti Infect Ther 2006;4:417-427.
  9. DuPont, HL. New insights and directions in travelers’ diarrhea. Gastroenterology Clinics N Amer 2006;35:337-353.
  10. Huang, DB, Mohanty, A, DuPont, HL, Okhuysen, PC, Chiang, T. A review of an enteric pathogen: enteroaggregative Escherichia coli. J Med Micro 2006;55:1303-1311.
  11. DuPont, HL. Azithromycin for the self-treatment of traveler’s diarrhea. (Editorial), Clin Infect Dis 2007;44:347-349.
  12. DuPont, HL. Relearning the importance of disease prevention among international travelers (letter). Amer J Gastroenterol. 2007;102:458-459.
  13. McMahan, ZH, DuPont, HL. Review article: the history of acute infectious diarrhoea management - from poorly focused empiricism to fluid therapy and modern pharmacotherapy. Alimentary Pharmacol Therapeutics 2007; ;25:759-769.
  14. Adachi, JA, Backer, HD, DuPont, HL. Infectious diarrhea from wilderness and foreign travel. Wilderness Medicine, Ed, Auerbach, PS., Mosby Elsevier, Philadelphia, PA; 2007;1418-1444.
  15. Hanauer, SB, DuPont, HL, Cooper, KM, Laudadio, C. Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort. Curr Med Res Opin 2007;23:1033-1043.
  16. DuPont, HL. Therapy and Prevention of traveler’s diarrhea. Tribute to Ted Woodward, Clin Infect Dis 2007;45:S78-S84.
  17. DuPont, HL. Approach to the patient with suspected enteric infection. Cecil Textbook of Medicine, 23rd Edition, Eds. Goldman L. Ausiello, D. Sanders, Philadelphia. 2007; 2132-2138.
  18. Marcos, LA, DuPont, HL. Advances in defining etiology and new therapeutic approaches in acute diarrhea. J Infect 2007;55:385-393.
  19. DuPont, HL. The growing threat of foodborne bacterial enteropathogens of animal origin. The 15th James H. Steele, DVM Lecture, Clin Infect Dis 2007;45:1353-1961
Books:
  1. DuPont, HL. Practical Antimicrobial Therapy (Lib. Cong. Number 78-55537). Appleton-Century-Crofts, New York, 1978.
  2. DuPont, HL. Uso Practico de Antimicrobianos, Interamericana, Mexico, 1980.
  3. DuPont, HL, Pickering, LK. Infections of the Gastrointestinal Tract, Microbiology, Pathophysiology and Clinical Features (Lib. Cong. Number 80-20352). Plenum Publishing Corp., New York, 1980.
  4. DuPont, HL, DuPont, MW. Travel with Health (Lib. Cong. Number 80-17810). Appleton-Century-Crofts, New York, 1981.
  5. Steele, JH, Beran, GW, Eds. and Section Eds.. Jukes, TH, DuPont, HL, Crawford, LM. Antibiotics, Sulfonamides, and Public Health, Vol. 1, Handbook Series in Zoonoses (Lib. Cong. Number 84-12742). CRC Press, Inc., Boca Raton, FL, 1984.
  6. Pickering, LK, DuPont, HL. Infectious Diseases of Children and Adults (Lib. Cong. Number 85-11258). Addison-Wesley Publ. Co., Menlo Park, CA, 1986.
  7. Kelley, WN, Ed-In-Chief and Section Eds. DeVita, VT Jr, DuPont, HL, Harris, ED Jr, Hazzard, WR, Holmes, EW, Hudson, LD, Humes, HD, Paty, DW, Watanabe, AM, Yamada, T. Textbook of Internal Medicine. (Lib. Cong. Number 88-26619.) JB Lippincott Co., Philadelphia, PA, 1989.
  8. Kelley, WN, Ed-In-Chief and Section Eds. DeVita, VT Jr, DuPont, HL, Harris, ED Jr, Hazzard, WR, Holmes, EW, Hudson, LD, Humes, HD, Paty, DW, Watanabe, AM, Yamada, T. Textbook of Internal Medicine. Second Edition (Lib. Cong. Number 91-10558.) JB Lippincott Co., Philadelphia, PA, 1992.
  9. DuPont, HL and Johnson, PC, Editors, Infectious Diseases, In Kelley’s Essentials of Internal Medicine, (Lib. Cong. Number ISBN 0-397-51272-4) Ed-In-Chief, Kelley, WN, JB Lippincott Co., Philadelphia, PA, 1994.
  10. Kelley, WN, Ed-In-Chief and Section Eds. DuPont, HL, Glick, JH, Harris, ED Jr, Hathaway, DR, Hazzard, WR, Holmes, EW, Hudson, LD, Humes, HD, Paty, DW, Yamada, T. Textbook of Internal Medicine. Third Edition (Lib. Cong. Number 96-14758.) Lippincott-Raven, Philadelphia, PA, 1997.
  11. DuPont, HL, Steffen, R. Textbook of Travel Medicine and Health. (Lib. Cong. Number ISBN 1-55009-037-2) B.C. Decker Inc., Hamilton, Ontario, 1997.
  12. Steffen, R, DuPont, HL. Manual of Travel Medicine and Health. (Lib. Cong. Number ISBN1-55009-078-X) B.C. Decker Inc., Hamilton, Ontario, 1999.
  13. Humes, HD, Ed-In-Chief and Section Eds. DuPont, HL, Gardner, LB, Griffin, JW, Harris, ED, Jr, Hazzard, WR, King, TE, Jr, Loriaux, DL, Nabel, EG, Todd, RF, III, Traber, PG. Kelley’s Textbook of Internal Medicine. Fourth Edition (Lib. Number ISBN0-7817-1787-6) Lippincott Williams & Wilkins, Philadelphia, PA, 2000.
  14. DuPont, HL, Steffen, R. Textbook of Travel Medicine and Health. Second Ed, (Lib. Cong. Number ISBN 1-55009-037-9) B.C. Decker Inc., Hamilton, Ontario, 2001.
  15. DuPont, HL and Johnson, PC, Editors. Infectious Disease In Kelley’s Essentials of Internal Medicine Second Edition, (Lib. Cong Number ISBN 0-7817-1937-2) Ed-In-Chief, Humes, HD, Lippincott Williams & Wilkins, 2001.
  16. Ericsson, CD, DuPont, HL and Steffen, R, Editors. Travelers’ Diarrhea. (Lib. Cong. Number ISBN 1-55009-219-7) B.C. Decker Inc., Hamilton, Ontario, 2003.
  17. Steffen, R, DuPont, HL, Wilder-Smith, A. Manual of Travel Medicine and Health, 2nd Ed. (Lib. Cong. Number ISBN 1-55009-2278), B.C. Decker Inc., Hamilton, Ontario, 2003.
  18. Steffen, R, DuPont, HL, Wilder-Smith, A. Manual of Travel Medicine and Health, 3rd Ed., (Lib. Cong. Number ISBN 978-1-55009-369-8), B.C. Decker Inc., Hamilton, Ontario, 2007.
  19. Ericsson, CD, DuPont, HL and Steffen, R, Editors. Travelers’ Diarrhea, 2nd Ed. (Lib. Cong. Number ISBN 978-155009-371-1), B.C. Decker Inc., Hamilton, Ontario, 2008.

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