David B. Corry, M.D.
Chief, Immunology, Allergy and Rheumatology
Cullen Trust for Health Care Endowed Chair in Immunology
Professor of Medicine and Immunology
Baylor College of Medicine
One Baylor Plaza - BCM285
Houston, Texas 77030
- M.D., University of Texas Southwestern Medical School, Dallas, Texas
- Residency, Duke University Medical Center, Durham, N.C.
- Clinical and Research Fellowship, Pulmonary and Critical Care Medicine, University of California at San Francisco, San Francisco
Dr. Corry's laboratory is interested in T cell mechanisms of disease and is currently focusing on the immune mechanisms underlying airway obstruction in a model of asthma. Using a mouse system, their studies have revealed the important roles of CD4+ T cells and the cytokines IL-4 and IL-13. They are pursuing understanding the composition and function of the murine IL-13 receptor and are dissecting the biochemistry of allergens that underlies the induction of allergic inflammation. Other related projects include defining the homing molecules required for Th1 and Th2 cells and understanding the role of short RNAs, including microRNAs and piRNAs, in immune gene expression. Finally, they are developing a novel T cell-based vaccination platform applicable to diverse pathogens.
Awards and Honors
- Nancy Chang, Ph.D., Professor, Biology of Inflammation Center, 2007
- Award for time devoted to the Pulmonary and Critical Care Medicine Fellowship Program, 2004-2005
- Research Excellence Award, American Academy of Allergy Asthma and Immunology International Conference, Rostrum on Creative Research, San Francisco, March, 2004
- Asthma and Allergy Foundation of America Investigator Award, 2001-2003
- Award for educational contributions to the Pulmonary and Critical Care Medicine Fellowship Program, 2002
- Porter P, Susarla SC, Polikepahad S, Qian Y, Hampton J, Kiss A, Vaidya S, Sur S, Delclos GL, Abramson S, Kheradmand F, Corry DB. Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi. Mucosal Immun. 2009 (doi:10.1038/mi.2009.102).
- Lee SH, Prince JE, Rais M, Kheradmand F, Ballantyne CM, Weitz-Schmidt G, Smith CW, Corry DB. Developmental control of integrin expression regulates Th2 effector homing. J Immunol. 2008; 180:4656-67.
- Kiss A, Montes M, Susarla S, Jaensson EA, Drouin SM, Wetsel R A, Yao Z, Martin R, Hamzeh N, Adelagun R, et al. A new mechanism regulating the initiation of allergic airway inflammation. J Allergy Clin Immunol. 2007; 120:334-42.
- Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight-White S, Green L, Hacken-Bitar J, Huh J, Bakaeen F, et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med. 2007; 13:567-9.
- Greenlee KJ, Corry DB, Engler DA, Matsunami RK, Tessier P, Cook RG, Werb Z, Kheradmand F. Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J Immunol. 2006; 177:7312-21.
- Grumelli S, Corry DB, Song LZ, Green L, Huh J, Hacken J, Espada R, Bag R, Lewis DE, Kheradmand F. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 2004; 1:75-83.
- Lee SH, Prince JE, Rais M, Kheradman, F, Shardonofsky F, Lu H, Beaudet AL, Smith CW, Soong L, Corry DB. Differential requirement for CD18 in T-helper effector homing. Nat Med. 2003; 9:1281-6.
- Corry DB, Rishi K, Kanellis J, Kiss A, Song LZ, Xu J, Feng L, Werb Z, Kheradmand F. Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol. 2002; 3, 347-53.
- Kheradmand F, Kiss A, Xu J, Lee SH, Kolattukudy PE, Corry DB. A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J Immunol. 2002; 169:5904-11.
- Corry DB, Kheradmand F. Induction and regulation of the IgE response. Nature. 1999; 402:B18-23.
- Van DykenSJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc P, Corry DB, LocksleyRM. Fungal chitin from asthma-associated home environments induces murine eosinophilic lung infiltration. J Immunol 2011; 187:2261-2267.
- Porter P, Fields A, Qian Y, Abramson S, Delclos GL, Kheradmand F, Corry DB. Necessary and sufficient role for T helper cells to prevent fungal dissemination during mucosal airway infection. Infect Immun 2011; 79:4459-4471.
- Pakdaman MN, Corry DB, Luong A. Fungi Linking the Pathophysiology of Chronic Rhinosinusitis with Nasal Polyps and Allergic Asthma. Immunol Invest 2011; 40:767-785.