Basic and Clinical Research
The division's research program focuses on regulation of vascular function in health and disease. Special emphasis is given to the role of vasoactive hormones, oxygen radicals, lipid-derived autocoids and leukocytes in vascular-injury produced by hypertension and by ischemia-reperfusion syndromes of the heart, kidneys and lungs.
The division also has an active clinical investigation program that focuses on characterization of the efficacy, safety and mechanisms of antihypertensive drugs, and on the clinical pharmacology (pharmacokinetics, pharmacodynamics, drug metabolism and human toxicology) of cardiovascular drugs.
Two special research units coordinate multidisciplinary vascular research: the Center for Experimental Therapeutics and the Hypertension-Clinical Pharmacology Research Clinic.
Faculty Research Interests
James L. Pool, M.D.
Professor of Medicine and Pharmacology
Cardiovascular Pharmacology, Alteration of Lipid Metabolism by Antihypertensive Drugs, Autonomic Nervous System Dysfunction