Hypertension and Clinical Pharmacology Fellowships
Addison A. Taylor, M.D., Ph.D.
Professor of Medicine and Pharmacology
One training position is offered each year. The Clinical Pharmacology fellowship is two years in duration, one year of clinical activities and one year devoted to a research project. Requirements for admission into the training program are board eligibility/certification in medicine or a related specialty. Applications must be received by Jan. 15. Interviews are conducted in January and February. Final decisions on acceptance into the training program is made by March 15. Applicants who successfully complete the program are eligible to take the certifying examination offered by the American Board of Clinical Pharmacology.
The objective of the training program in hypertension and clinical pharmacology is the development of a physician who is:
- well grounded in basic and analytic pharmacology methods;
- capable of initiating an independent research program in the area of hypertension and/or clinical pharmacology;
- aware of clinical trials methodology and ethics of human experimentation and able to carry out effective clinical trials;
- fully prepared to provide consultation in hypertension and clinical pharmacology in an academic setting.
The curriculum presents pathophysiologic mechanisms of hypertension and basic principles of clinical pharmacology including clinical study design, pharmacokinetics, pharmacodynamics, drug metabolism, and human toxicology. Tutorials on relevant clinical research topics including clinical trials design, bioethics, biostatistics, and FDA regulation of clinical research are provided by the faculty during weekly clinical pharmacology conferences and teaching sessions. The research program focuses on regulation of vascular function in health and disease. Special emphasis is given to the role of vasoactive hormones, oxygen radicals, lipid-derived autocoids, and leukocytes in vascular injury produced hypertension and by ischemia-reperfusion syndromes of the heart, kidney, and lungs.
Trainees are expected to spend three months during their first year in the Clinical Pharmacology Research and Diagnostic Clinic at The Methodist Hospital and three months on the Hypertension and Clinical Pharmacology Consultation Service at that same facility. Additional time, usually three months, is spent in the Clinical Pharmacokinetics Core Laboratory either at Baylor College of Medicine or at Texas Children's Hospital. Throughout their training, fellows are expected to attend an outpatient continuity clinic one-half day per week. Using the clinical consultation service and the individual research projects as vehicles, the trainee spends much of the training period developing research and specialized clinical skills during one-on-one involvement with the various faculty members. Elective time may be spent in a number of related areas; for example, learning state-of-the-art mass spectrometry methodology in the Center for Experimental Therapeutics, learning to evaluate ischemia-reflow toxicity in various organ systems, studying the normal and abnormal regulation of blood vessel function, and application of this information to any of the various clinical subspecialties represented among the faculty.
The weekly clinical conference includes discussion of cases seen in consultation and clinical research programs. A weekly research conference includes discussion of findings in both basic and clinical research programs being carried out by faculty and trainees. A weekly Clinical Pharmacology Grand Rounds includes participation by faculty throughout the Texas Medical Center and features nationally or internationally recognized visiting faculty from other institutions at least once monthly.
In general the trainee, in conjunction with the faculty in one of several departments or internal medicine divisions within the College, determines an area of interest. Working with a faculty member who has expertise in the area, a realistic research plan is structured for the two-year training period. Emphasis is on originality and development of independence of the trainee with a goal of creating an environment for the development of a future independent investigator. Diversity of the faculty allows the trainee to focus on either a clinical or basic research project.
Division of Hypertension and Clinical Pharmacology
Baylor College of Medicine
One Baylor Place, MC620