Jose M. Garcia, M.D., Ph.D.
Assistant Professor of Medicine, Molecular & Cellular
Biology, and Huffington Center on Aging
Baylor College of Medicine
Co-director, Center for Translational Research in Inflammatory Diseases (CTRID)
Michael E. DeBakey VA Medical Center
2002 Holcombe Blvd. (111E)
Houston, TX 77030
- M.D.: Catholic University of Cordoba School of Medicine, Cordoba, Argentina, 1997
- Residency: Internal Medicine, George Washington University, Washington, D.C., 2002
- Fellowship: Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, 2004
- Ph.D. in Clinical Investigation: Baylor College of Medicine, Houston, TX, 2011
- Muscle wasting and cachexia
- Ghrelin and GH/IGF-1 axis
- Testosterone and hypogonadism
My current research focuses on the role of ghrelin and other anabolic pathways in different wasting conditions. My group is currently involved in several human trials using different anabolic therapies for the treatment of wasting as well as in the development of different animal models to unravel the physiology of wasting and the mechanisms of action of different potential therapies.
- Garcia JM, Garcia-Touza M, Hijazi RA, Taffet G, Epner D, Mann D, Smith RG, Cunningham GR, Marcelli M 2005 Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia. J Clin Endocrinol Metab 90:2920-2926
- Garcia JM, Iyer D, Poston WS, Marcelli M, Reeves R, Foreyt J, Balasubramanyam A 2006 Rise of plasma ghrelin with weight loss is not sustained during weight maintenance. Obesity (Silver Spring) 14:1716-1723
- Garcia JM, Li H, Mann D, Epner D, Hayes TG, Marcelli M, Cunningham GR 2006 Hypogonadism in male patients with cancer. Cancer 106:2583-2591
- Garcia JM, Polvino WJ 2007 Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers. Oncologist 12:594-600
- Sun Y, Garcia JM, Smith RG 2007 Ghrelin and growth hormone secretagogue receptor expression in mice during aging. Endocrinology 148:1323-1329
- Garcia JM, Cata JP, Dougherty PM, Smith RG 2008 Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia. Endocrinology 149:455-460
- Sun Y, Butte NF, Garcia JM, Smith RG 2008 Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology 149:843-850
- Garcia JM, Polvino WJ 2009 Pharmacodynamic hormonal effects, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers. Growth Horm IGF Res. 2009 Jun;19(3):267-73. PMID: 19196529
- Tan HY, Garcia JM 2010 Association between Insulinoma and Adrenal Insufficiency: A Case Report and Review of the Literature. Pancreas. May;39(4):544-6. PMID: 20418760
- Smiechowska J, Utech AE, Taffet G, Hayes T, Marcelli M, Garcia JM. 2010 The role of adipokines in patients with cancer anorexia and cachexia. J Investig Med. Mar;58(3):554-9. PMID: 20215915.
- Garcia, J.M., Sharafkhaneh, H., Hirshkowitz, M., Elkhatib, R., and Sharafkhaneh, A. 2011 Weight and metabolic effects of cpap in obstructive sleep apnea patients with obesity. Respir Res 12:80. PMID: 21676224
- Engineer DR, Garcia JM. 2012 Leptin in anorexia and cachexia syndrome.Int J Pept. 2012;2012:287457.
- Burney BO, Hayes TG, Smiechowska J, Cardwell G, Papusha G, Bhargava P, Konda B, Auchus R, Garcia JM. 2012 Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia. J Clin Endocrinol Metab. 2012 May;97(5):E700-9
- Burney BO, Garcia JM. 2012 Hypogonadism in male cancer patients. J Cachexia Sarcopenia Muscle. Sep;3(3):149-55
- Utech AE, Tadros EM, Hayes TG, Garcia JM. 2012 Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers J Cachexia Sarcopenia Muscle. Dec;3(4):245-51
- Garcia JM, Friend S, Allen S. 2013 Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study. Support Care Cancer. Jun 16. Jan;21(1):129-37
- El-Serag, HB, Hashmi A, Garcia JM, Richardson P, Alsarraj, A, Fitzgerald S, Vela M, Shaib Y, Abraham N, Velez M, Cole R, Hacken-Bittar J, Anand B, Grahaym DY, Kramer JR. 2013 Visceral abdominal obesity measured by CT scan is associated with an increased risk of Barrett's esophagus. Gut, Feb 13 [Epub ahead of print]
- Garcia JM, Swerdloff R, Wang C, Kyle M, Kipnes M, Biller BMK, Cook D, Yuen KCJ, Bonert V, Dobs A, Molitch M, Merriam GR. 2013 Macimorelin (AEZS-130)-Stimulated Growth Hormone (GH) test: Validation of a Novel Oral Stimulation Test for the Diagnosis of Adult GH Deficiency. J Clin Endocrinol Metab. April 4 [Epub ahead of print]
- Garcia JM: "Anabolic therapies" in: Del Fabbro E, Bruera E, Demark W, Baracos V, Bowking T, Hopkinson J (Ed) "Nutrition in cancer patients, principles and practice" (Oxford, UK) Oxford Univeristy Press, 2010.
- Burney BO, Garcia JM: "Use of ghrelin and ghrelin receptor angonists in cnacer - and chemotherapy-induced cachexia" in: Smith RG and Thorner MO (Ed) "Ghrelin in health and disease" Springer Science.
- Marcelli M, Cunnningham GR, Garcia JM, Lamb DJ: "The molecular basis of testicular diseases". In: JL Jameson (ed) "Textbook of Molecular Medicine" Totowa (NJ), Humana Press, 2004.